Thrombin Upregulates Tissue Transglutaminase in Endothelial Cells: A Potential Role for Tissue Transglutaminase in Stability of Atherosclerotic Plaque

ABSTRACT—Atherosclerosis is characterized by thickening of the vessel wall, smooth muscle cell proliferation, macrophage infiltration, and deposition of a fibrin network. Transglutaminases are a family of enzymes catalyzing the formation of stable covalent cross-links between proteins. Here, we show...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2001-10, Vol.21 (10), p.1689-1694
Hauptverfasser:	Auld, Gillian C, Ritchie, Helen, Robbie, Linda A, Booth, Nuala A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Aorta - enzymology Aortic Diseases - enzymology Aortic Diseases - pathology Arteriosclerosis - enzymology Arteriosclerosis - genetics Arteriosclerosis - pathology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cells, Cultured Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology GTP-Binding Proteins - biosynthesis GTP-Binding Proteins - genetics GTP-Binding Proteins - physiology Humans Medical sciences Muscle, Smooth, Vascular - enzymology RNA, Messenger - biosynthesis Thrombin - pharmacology Transglutaminases - biosynthesis Transglutaminases - genetics Transglutaminases - physiology Up-Regulation
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