Chronic treatment with nicotine or potassium attenuates depolarisation-evoked noradrenaline release from the human neuroblastoma SH-SY5Y

Chronic treatment, of SH-SY5Y cells, with KCl (20 mM) for 4 days decreased 100 mM KCl-evoked noradrenaline (NA) release by 50% and nicotine (100 μM)-evoked NA release by 55%. Pretreatment with the L-type calcium channel antagonist, nifedipine, prevented this inhibitory effect of chronic exposure to...

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Veröffentlicht in:	Neuroscience letters 2002-10, Vol.331 (3), p.167-170
Hauptverfasser:	Agis-Torres, Angel, Ball, Stephen G., Vaughan, Peter F.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell physiology Fundamental and applied biological sciences. Psychology Ganglionic Stimulants - pharmacology Humans L-type calcium channels Membrane Potentials - drug effects Miscellaneous Molecular and cellular biology Neuroblastoma - metabolism Neuroblastoma SH-SY5Y Nicotine Nicotine - pharmacology Noradrenaline release Norepinephrine - biosynthesis Potassium Chloride - pharmacology Time Factors Tumor Cells, Cultured Veratridine - pharmacology
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