Chronic treatment with nicotine or potassium attenuates depolarisation-evoked noradrenaline release from the human neuroblastoma SH-SY5Y
Chronic treatment, of SH-SY5Y cells, with KCl (20 mM) for 4 days decreased 100 mM KCl-evoked noradrenaline (NA) release by 50% and nicotine (100 μM)-evoked NA release by 55%. Pretreatment with the L-type calcium channel antagonist, nifedipine, prevented this inhibitory effect of chronic exposure to...
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| Veröffentlicht in: | Neuroscience letters 2002-10, Vol.331 (3), p.167-170 |
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| container_end_page | 170 |
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| container_title | Neuroscience letters |
| container_volume | 331 |
| creator | Agis-Torres, Angel Ball, Stephen G. Vaughan, Peter F.T. |
| description | Chronic treatment, of SH-SY5Y cells, with KCl (20 mM) for 4 days decreased 100 mM KCl-evoked noradrenaline (NA) release by 50% and nicotine (100 μM)-evoked NA release by 55%. Pretreatment with the L-type calcium channel antagonist, nifedipine, prevented this inhibitory effect of chronic exposure to 20 mM KCl on NA release. In contrast pretreatment with 10 μM nicotine for 4 days had no effect on 100 mM KCl -evoked secretion and decreased nicotinic -evoked NA release by only 25%. Inclusion of nifedipine prevented the inhibition of NA release by chronic nicotine treatment. These data are discussed in relation to effects of chronic moderate, depolarisation by either K
+ or nicotine on influx of Ca
2+ via L-type voltage sensitive calcium channels. |
| doi_str_mv | 10.1016/S0304-3940(02)00881-9 |
| format | Article |
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+ or nicotine on influx of Ca
2+ via L-type voltage sensitive calcium channels.</description><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglionic Stimulants - pharmacology</subject><subject>Humans</subject><subject>L-type calcium channels</subject><subject>Membrane Potentials - drug effects</subject><subject>Miscellaneous</subject><subject>Molecular and cellular biology</subject><subject>Neuroblastoma - metabolism</subject><subject>Neuroblastoma SH-SY5Y</subject><subject>Nicotine</subject><subject>Nicotine - pharmacology</subject><subject>Noradrenaline release</subject><subject>Norepinephrine - biosynthesis</subject><subject>Potassium Chloride - pharmacology</subject><subject>Time Factors</subject><subject>Tumor Cells, Cultured</subject><subject>Veratridine - pharmacology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhSMEotvCTwD5AiqHwNhOYvtUoRVQpEocFg49WbPORGtI7MV2ivgH_Gyy3RU9chpp9L03o_eq6gWHtxx4924DEppamgYuQbwB0JrX5lG14lqJWhklHlerf8hZdZ7zdwBoeds8rc64kFoaIVfVn_UuxeAdK4mwTBQK--XLji2rWHwgFhPbx4I5-3liWAqFGQtl1tM-jph8xuJjqOku_qCehZiwTxRwPGgTjYSZ2JDixMqO2G6eMLBAc4rbEXOJE7LNdb25bW-fVU8GHDM9P82L6tvHD1_X1_XNl0-f1-9vaicNL7XGzjhlNHAk0SFAo4VTjtPQduAI2gacHtot57JRAyrVadCSWtUREEcuL6rXR999ij9nysVOPjsaRwwU52yV4AaUEAvYHkGXYs6JBrtPfsL023KwhwrsfQX2kK8FYe8rsGbRvTwdmLcT9Q-qU-YL8OoEYHY4DgmD8_mBk6Y1AGrhro4cLXHceUo2O0_BUe8TuWL76P_zyl81DqU9</recordid><startdate>20021018</startdate><enddate>20021018</enddate><creator>Agis-Torres, Angel</creator><creator>Ball, Stephen G.</creator><creator>Vaughan, Peter F.T.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021018</creationdate><title>Chronic treatment with nicotine or potassium attenuates depolarisation-evoked noradrenaline release from the human neuroblastoma SH-SY5Y</title><author>Agis-Torres, Angel ; Ball, Stephen G. ; Vaughan, Peter F.T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-8a69c79801ae26a00482c7c1ef560ce0540c8f5b11347fa7768083e576e0e1a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglionic Stimulants - pharmacology</topic><topic>Humans</topic><topic>L-type calcium channels</topic><topic>Membrane Potentials - drug effects</topic><topic>Miscellaneous</topic><topic>Molecular and cellular biology</topic><topic>Neuroblastoma - metabolism</topic><topic>Neuroblastoma SH-SY5Y</topic><topic>Nicotine</topic><topic>Nicotine - pharmacology</topic><topic>Noradrenaline release</topic><topic>Norepinephrine - biosynthesis</topic><topic>Potassium Chloride - pharmacology</topic><topic>Time Factors</topic><topic>Tumor Cells, Cultured</topic><topic>Veratridine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agis-Torres, Angel</creatorcontrib><creatorcontrib>Ball, Stephen G.</creatorcontrib><creatorcontrib>Vaughan, Peter F.T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agis-Torres, Angel</au><au>Ball, Stephen G.</au><au>Vaughan, Peter F.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic treatment with nicotine or potassium attenuates depolarisation-evoked noradrenaline release from the human neuroblastoma SH-SY5Y</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2002-10-18</date><risdate>2002</risdate><volume>331</volume><issue>3</issue><spage>167</spage><epage>170</epage><pages>167-170</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Chronic treatment, of SH-SY5Y cells, with KCl (20 mM) for 4 days decreased 100 mM KCl-evoked noradrenaline (NA) release by 50% and nicotine (100 μM)-evoked NA release by 55%. Pretreatment with the L-type calcium channel antagonist, nifedipine, prevented this inhibitory effect of chronic exposure to 20 mM KCl on NA release. In contrast pretreatment with 10 μM nicotine for 4 days had no effect on 100 mM KCl -evoked secretion and decreased nicotinic -evoked NA release by only 25%. Inclusion of nifedipine prevented the inhibition of NA release by chronic nicotine treatment. These data are discussed in relation to effects of chronic moderate, depolarisation by either K
+ or nicotine on influx of Ca
2+ via L-type voltage sensitive calcium channels.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>12383923</pmid><doi>10.1016/S0304-3940(02)00881-9</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 2002-10, Vol.331 (3), p.167-170 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences Cell physiology Fundamental and applied biological sciences. Psychology Ganglionic Stimulants - pharmacology Humans L-type calcium channels Membrane Potentials - drug effects Miscellaneous Molecular and cellular biology Neuroblastoma - metabolism Neuroblastoma SH-SY5Y Nicotine Nicotine - pharmacology Noradrenaline release Norepinephrine - biosynthesis Potassium Chloride - pharmacology Time Factors Tumor Cells, Cultured Veratridine - pharmacology |
| title | Chronic treatment with nicotine or potassium attenuates depolarisation-evoked noradrenaline release from the human neuroblastoma SH-SY5Y |
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