2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides
2-(Anilinomethyl)imidazolines with 2'-esters or 2'-amides are potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The size and shape of the ortho substituent can have significant effects on the potency, efficacy, and subtype selectivity of these 2-(anilinomethyl)imidazolin...
Gespeichert in:
| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2001-11, Vol.11 (21), p.2871-2874 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2874 |
|---|---|
| container_issue | 21 |
| container_start_page | 2871 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 11 |
| creator | Bishop, M J Berman, J Bigham, E C Garrison, D T Gobel, M J Hodson, S J Irving, P E Liacos, J A Minick, D J Navas, F Saussy, Jr, D L Speake, J D |
| description | 2-(Anilinomethyl)imidazolines with 2'-esters or 2'-amides are potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The size and shape of the ortho substituent can have significant effects on the potency, efficacy, and subtype selectivity of these 2-(anilinomethyl)imidazolines. alpha(1A)-subtype selective agonists have been identified. |
| doi_str_mv | 10.1016/S0960-894X(01)00569-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72190712</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72190712</sourcerecordid><originalsourceid>FETCH-LOGICAL-p209t-27fa10c8be44ca42978794ed604bf67a3fed9f3d19a298cbe05dbdfe70013f6f3</originalsourceid><addsrcrecordid>eNo9UM1KxDAYzEFx19VHUHLS3UM0abNt421Z_IMFDyp4K2nyxY20SW1Ssb6Ir2tBV_hgYJj5ZhiEThi9YJRll49UZJQUgr_MKVtQuswEKfbQ9J-eoMMQ3ihlnHJ-gCaMLUXOmZii74TMV87W1vkG4naoF7axWn75kYGA5Xh1u5VztiBSd-C8gjb6DstX72yI4QrHLWCrwUVrrJLReoe92blWCxz6Kg4t4AA1qGg_ACfnRMmu8p9DbRWWymoMIUI3ZjmN5ZgP4QjtG1kHOP7DGXq-uX5a35HNw-39erUhbUJFJEluJKOqqIBzJXki8iIXHHRGeWWyXKYGtDCpZkImolAV0KWutIF83CI1mUln6Oz3b9v5936sUTY2KKhr6cD3ocwTJmjOklF4-ifsqwZ02Xa2kd1Q7qZMfwCnynfS</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72190712</pqid></control><display><type>article</type><title>2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Bishop, M J ; Berman, J ; Bigham, E C ; Garrison, D T ; Gobel, M J ; Hodson, S J ; Irving, P E ; Liacos, J A ; Minick, D J ; Navas, F ; Saussy, Jr, D L ; Speake, J D</creator><creatorcontrib>Bishop, M J ; Berman, J ; Bigham, E C ; Garrison, D T ; Gobel, M J ; Hodson, S J ; Irving, P E ; Liacos, J A ; Minick, D J ; Navas, F ; Saussy, Jr, D L ; Speake, J D</creatorcontrib><description>2-(Anilinomethyl)imidazolines with 2'-esters or 2'-amides are potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The size and shape of the ortho substituent can have significant effects on the potency, efficacy, and subtype selectivity of these 2-(anilinomethyl)imidazolines. alpha(1A)-subtype selective agonists have been identified.</description><identifier>ISSN: 0960-894X</identifier><identifier>DOI: 10.1016/S0960-894X(01)00569-8</identifier><identifier>PMID: 11597419</identifier><language>eng</language><publisher>England</publisher><subject>Adrenergic alpha-1 Receptor Agonists ; Adrenergic alpha-Agonists - chemistry ; Adrenergic alpha-Agonists - pharmacology ; Amides - chemistry ; Carboxylic Acids - chemistry ; Esters - chemistry ; Imidazoles - chemistry ; Imidazoles - pharmacology ; Structure-Activity Relationship</subject><ispartof>Bioorganic & medicinal chemistry letters, 2001-11, Vol.11 (21), p.2871-2874</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11597419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bishop, M J</creatorcontrib><creatorcontrib>Berman, J</creatorcontrib><creatorcontrib>Bigham, E C</creatorcontrib><creatorcontrib>Garrison, D T</creatorcontrib><creatorcontrib>Gobel, M J</creatorcontrib><creatorcontrib>Hodson, S J</creatorcontrib><creatorcontrib>Irving, P E</creatorcontrib><creatorcontrib>Liacos, J A</creatorcontrib><creatorcontrib>Minick, D J</creatorcontrib><creatorcontrib>Navas, F</creatorcontrib><creatorcontrib>Saussy, Jr, D L</creatorcontrib><creatorcontrib>Speake, J D</creatorcontrib><title>2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>2-(Anilinomethyl)imidazolines with 2'-esters or 2'-amides are potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The size and shape of the ortho substituent can have significant effects on the potency, efficacy, and subtype selectivity of these 2-(anilinomethyl)imidazolines. alpha(1A)-subtype selective agonists have been identified.</description><subject>Adrenergic alpha-1 Receptor Agonists</subject><subject>Adrenergic alpha-Agonists - chemistry</subject><subject>Adrenergic alpha-Agonists - pharmacology</subject><subject>Amides - chemistry</subject><subject>Carboxylic Acids - chemistry</subject><subject>Esters - chemistry</subject><subject>Imidazoles - chemistry</subject><subject>Imidazoles - pharmacology</subject><subject>Structure-Activity Relationship</subject><issn>0960-894X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UM1KxDAYzEFx19VHUHLS3UM0abNt421Z_IMFDyp4K2nyxY20SW1Ssb6Ir2tBV_hgYJj5ZhiEThi9YJRll49UZJQUgr_MKVtQuswEKfbQ9J-eoMMQ3ihlnHJ-gCaMLUXOmZii74TMV87W1vkG4naoF7axWn75kYGA5Xh1u5VztiBSd-C8gjb6DstX72yI4QrHLWCrwUVrrJLReoe92blWCxz6Kg4t4AA1qGg_ACfnRMmu8p9DbRWWymoMIUI3ZjmN5ZgP4QjtG1kHOP7DGXq-uX5a35HNw-39erUhbUJFJEluJKOqqIBzJXki8iIXHHRGeWWyXKYGtDCpZkImolAV0KWutIF83CI1mUln6Oz3b9v5936sUTY2KKhr6cD3ocwTJmjOklF4-ifsqwZ02Xa2kd1Q7qZMfwCnynfS</recordid><startdate>20011105</startdate><enddate>20011105</enddate><creator>Bishop, M J</creator><creator>Berman, J</creator><creator>Bigham, E C</creator><creator>Garrison, D T</creator><creator>Gobel, M J</creator><creator>Hodson, S J</creator><creator>Irving, P E</creator><creator>Liacos, J A</creator><creator>Minick, D J</creator><creator>Navas, F</creator><creator>Saussy, Jr, D L</creator><creator>Speake, J D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20011105</creationdate><title>2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides</title><author>Bishop, M J ; Berman, J ; Bigham, E C ; Garrison, D T ; Gobel, M J ; Hodson, S J ; Irving, P E ; Liacos, J A ; Minick, D J ; Navas, F ; Saussy, Jr, D L ; Speake, J D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-27fa10c8be44ca42978794ed604bf67a3fed9f3d19a298cbe05dbdfe70013f6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adrenergic alpha-1 Receptor Agonists</topic><topic>Adrenergic alpha-Agonists - chemistry</topic><topic>Adrenergic alpha-Agonists - pharmacology</topic><topic>Amides - chemistry</topic><topic>Carboxylic Acids - chemistry</topic><topic>Esters - chemistry</topic><topic>Imidazoles - chemistry</topic><topic>Imidazoles - pharmacology</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bishop, M J</creatorcontrib><creatorcontrib>Berman, J</creatorcontrib><creatorcontrib>Bigham, E C</creatorcontrib><creatorcontrib>Garrison, D T</creatorcontrib><creatorcontrib>Gobel, M J</creatorcontrib><creatorcontrib>Hodson, S J</creatorcontrib><creatorcontrib>Irving, P E</creatorcontrib><creatorcontrib>Liacos, J A</creatorcontrib><creatorcontrib>Minick, D J</creatorcontrib><creatorcontrib>Navas, F</creatorcontrib><creatorcontrib>Saussy, Jr, D L</creatorcontrib><creatorcontrib>Speake, J D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bishop, M J</au><au>Berman, J</au><au>Bigham, E C</au><au>Garrison, D T</au><au>Gobel, M J</au><au>Hodson, S J</au><au>Irving, P E</au><au>Liacos, J A</au><au>Minick, D J</au><au>Navas, F</au><au>Saussy, Jr, D L</au><au>Speake, J D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2001-11-05</date><risdate>2001</risdate><volume>11</volume><issue>21</issue><spage>2871</spage><epage>2874</epage><pages>2871-2874</pages><issn>0960-894X</issn><abstract>2-(Anilinomethyl)imidazolines with 2'-esters or 2'-amides are potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The size and shape of the ortho substituent can have significant effects on the potency, efficacy, and subtype selectivity of these 2-(anilinomethyl)imidazolines. alpha(1A)-subtype selective agonists have been identified.</abstract><cop>England</cop><pmid>11597419</pmid><doi>10.1016/S0960-894X(01)00569-8</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2001-11, Vol.11 (21), p.2871-2874 |
| issn | 0960-894X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72190712 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adrenergic alpha-1 Receptor Agonists Adrenergic alpha-Agonists - chemistry Adrenergic alpha-Agonists - pharmacology Amides - chemistry Carboxylic Acids - chemistry Esters - chemistry Imidazoles - chemistry Imidazoles - pharmacology Structure-Activity Relationship |
| title | 2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T13%3A28%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=2-(Anilinomethyl)imidazolines%20as%20alpha(1)-adrenoceptor%20agonists:%20the%20identification%20of%20alpha(1A)%20subtype%20selective%202'-carboxylic%20acid%20esters%20and%20amides&rft.jtitle=Bioorganic%20&%20medicinal%20chemistry%20letters&rft.au=Bishop,%20M%20J&rft.date=2001-11-05&rft.volume=11&rft.issue=21&rft.spage=2871&rft.epage=2874&rft.pages=2871-2874&rft.issn=0960-894X&rft_id=info:doi/10.1016/S0960-894X(01)00569-8&rft_dat=%3Cproquest_pubme%3E72190712%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72190712&rft_id=info:pmid/11597419&rfr_iscdi=true |