Traceless Solid-Phase Synthesis of 1,2,4-Triazoles Using a Novel Amine Resin

A solid-phase route to 5-aryl-3-arylthiomethyl-1,2,4-triazoles has been developed that permits the incorporation of two elements of diversity. The heterocycle was constructed upon a novel 4-benzyloxy-2-methoxybenzylamine (BOMBA) resin, from which traceless cleavage could be effected with dilute TFA....

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Veröffentlicht in:	Organic letters 2001-10, Vol.3 (21), p.3341-3344
Hauptverfasser:	Larsen, Scott D, DiPaolo, Brian A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemistry Chemistry, Pharmaceutical Combinatorial Chemistry Techniques Resins, Synthetic - chemistry Triazoles - chemical synthesis
Online-Zugang:	Volltext
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