Physiological variation in metabolic phenotyping and functional genomic studies: use of orthogonal signal correction and PLS-DA

Metabolic phenotyping, or metabotyping, is increasingly being used as a probe in functional genomics studies. However, such profiling is subject to intrinsic physiological variation found in all animal populations. Using a nuclear magnetic resonance-based metabonomic approach, we show that diurnal v...

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Veröffentlicht in:	FEBS letters 2002-10, Vol.530 (1), p.191-196
Hauptverfasser:	Gavaghan, C.L, Wilson, I.D, Nicholson, J.K
Format:	Artikel
Sprache:	eng
Schlagworte:	1H NMR spectroscopy Animals Genomics Magnetic Resonance Spectroscopy Metabonomics Mice Orthogonal signal correction Phenotype Physiological variation Species Specificity
Online-Zugang:	Volltext
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