Requirement of c-Jun N-Terminal Kinase for Apoptotic Cell Death Induced by Farnesyltransferase Inhibitor, Farnesylamine, in Human Pancreatic Cancer Cells

Farnesyltransferase inhibitors (FTIs) represent a novel class of anticancer drugs and are now in clinical trial. We have previously shown that farnesylamine, synthetic isoprenoid-linked with “amine” which acts as a potent FTI, induces apoptosis in human pancreatic cancer cells through the ras signal...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-10, Vol.288 (1), p.198-204
Hauptverfasser:	Mizukami, Yusuke, Ura, Hitoshi, Obara, Takeshi, Habiro, Atsuya, Izawa, Tsutomu, Osanai, Manabu, Yanagawa, Nobuyuki, Tanno, Satoshi, Kohgo, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyl and Aryl Transferases - antagonists & inhibitors Amines - pharmacology Antineoplastic Agents - pharmacology Apoptosis c-jun N-terminal kinase Enzyme Inhibitors - pharmacology Farnesol - analogs & derivatives Farnesol - pharmacology farnesyltransferase inhibitor Farnesyltranstransferase Genes, ras Humans isoprenoid JNK Mitogen-Activated Protein Kinases long-chain fatty amine MAP Kinase Signaling System Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - physiology Mutation pancreatic cancer Pancreatic Neoplasms - enzymology Pancreatic Neoplasms - pathology Tumor Cells, Cultured
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