Hypermethylation-associated inactivation of the cellular retinol-binding-protein 1 gene in human cancer

The effects of retinol (vitamin A) depend on its transport and binding to nuclear receptors. The cellular retinol-binding protein 1 (CRBP1) and the retinoic acid receptor beta2 (RARbeta2) are key components of this process. Loss of CRBP1 expression occurs in breast tumors, but the mechanism is not k...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2002-10, Vol.62 (20), p.5902-5905
Hauptverfasser:	ESTELLER, Manel, MINGZHOU GUO, MORENO, Victor, PEINADO, Miquel Angel, CAPELLA, Gabriel, GALM, Oliver, BAVLIN, Stenhen B, HERMAN, James G
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences CpG Islands Diet DNA Methylation Gene Expression Regulation, Neoplastic Gene Silencing Humans Medical sciences Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - genetics Neoplasms - metabolism Promoter Regions, Genetic Receptors, Retinoic Acid - genetics Retinol-Binding Proteins - biosynthesis Retinol-Binding Proteins - genetics Retinol-Binding Proteins, Cellular Tumor Cells, Cultured Tumors Vitamin A - pharmacology
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