Presence of cystic fibrosis-related diabetes mellitus is tightly linked to poor lung function in patients with cystic fibrosis: Data from the European Epidemiologic Registry of Cystic Fibrosis
Data derived from a cross‐sectional analysis of 7,566 patients stratified into six age groups were used to compare lung function, body mass index (BMI), and weight for age in patients with and without cystic fibrosis‐related diabetes mellitus (CFDM). The presence of CFDM was tightly linked to poor l...
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| Veröffentlicht in: | Pediatric pulmonology 2001-11, Vol.32 (5), p.343-350 |
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| container_title | Pediatric pulmonology |
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| creator | Koch, C. Rainisio, M. Madessani, U. Harms, H.K. Hodson, M.E. Mastella, G. McKenzie, S.G. Navarro, J. Strandvik, B. |
| description | Data derived from a cross‐sectional analysis of 7,566 patients stratified into six age groups were used to compare lung function, body mass index (BMI), and weight for age in patients with and without cystic fibrosis‐related diabetes mellitus (CFDM).
The presence of CFDM was tightly linked to poor lung function, regardless of age. The mean value of FEV1 % predicted in the age groups |
| doi_str_mv | 10.1002/ppul.1142 |
| format | Article |
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The presence of CFDM was tightly linked to poor lung function, regardless of age. The mean value of FEV1 % predicted in the age groups < 10, 10–< 15, 15–< 20, 20–< 25, 25–< 30, and 30 years or older were 87%, 77%, 69%, 58%, 55%, and 53% in the nondiabetic cystic fibrosis (CF) patients as compared to 79%, 66%, 55%, 49%, 46%, and 44% in the diabetic CF patients. BMI and weight for age were also lower in diabetic than nondiabetic CF patients in all age groups, except for BMI in the youngest patients. The difference in lung function and in nutritional parameters between diabetic and nondiabetic CF patients was not linked to presence or absence of any specific pathogen in the lower respiratory tract.
These results confirm and extend those of earlier studies in smaller numbers of patients, and they clearly identify CFDM as a powerful determinant of severe lung disease and reduced survival in patients with CF and diabetis mellitus. Pediatr Pulmonol. 2001; 32:343–350. © 2001 Wiley‐Liss, Inc.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.1142</identifier><identifier>PMID: 11596158</identifier><identifier>CODEN: PEPUES</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Body Mass Index ; Child ; cystic fibrosis ; Cystic Fibrosis - complications ; Cystic Fibrosis - physiopathology ; Diabetes Complications ; diabetes mellitus ; Diabetes Mellitus - physiopathology ; Forced Expiratory Volume ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Other diseases. Semiology ; pulmonary function ; registry ; Vital Capacity</subject><ispartof>Pediatric pulmonology, 2001-11, Vol.32 (5), p.343-350</ispartof><rights>Copyright © 2001 Wiley‐Liss, Inc.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2001 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3892-f14a9e82089883c8c52dee8c56d442edc5075d19f3f20cfe35ae2e82feb556e83</citedby><cites>FETCH-LOGICAL-c3892-f14a9e82089883c8c52dee8c56d442edc5075d19f3f20cfe35ae2e82feb556e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.1142$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.1142$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14139964$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11596158$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koch, C.</creatorcontrib><creatorcontrib>Rainisio, M.</creatorcontrib><creatorcontrib>Madessani, U.</creatorcontrib><creatorcontrib>Harms, H.K.</creatorcontrib><creatorcontrib>Hodson, M.E.</creatorcontrib><creatorcontrib>Mastella, G.</creatorcontrib><creatorcontrib>McKenzie, S.G.</creatorcontrib><creatorcontrib>Navarro, J.</creatorcontrib><creatorcontrib>Strandvik, B.</creatorcontrib><creatorcontrib>Investigators of the European Epidemiologic Registry of Cystic Fibrosis</creatorcontrib><title>Presence of cystic fibrosis-related diabetes mellitus is tightly linked to poor lung function in patients with cystic fibrosis: Data from the European Epidemiologic Registry of Cystic Fibrosis</title><title>Pediatric pulmonology</title><addtitle>Pediatr. Pulmonol</addtitle><description>Data derived from a cross‐sectional analysis of 7,566 patients stratified into six age groups were used to compare lung function, body mass index (BMI), and weight for age in patients with and without cystic fibrosis‐related diabetes mellitus (CFDM).
The presence of CFDM was tightly linked to poor lung function, regardless of age. The mean value of FEV1 % predicted in the age groups < 10, 10–< 15, 15–< 20, 20–< 25, 25–< 30, and 30 years or older were 87%, 77%, 69%, 58%, 55%, and 53% in the nondiabetic cystic fibrosis (CF) patients as compared to 79%, 66%, 55%, 49%, 46%, and 44% in the diabetic CF patients. BMI and weight for age were also lower in diabetic than nondiabetic CF patients in all age groups, except for BMI in the youngest patients. The difference in lung function and in nutritional parameters between diabetic and nondiabetic CF patients was not linked to presence or absence of any specific pathogen in the lower respiratory tract.
These results confirm and extend those of earlier studies in smaller numbers of patients, and they clearly identify CFDM as a powerful determinant of severe lung disease and reduced survival in patients with CF and diabetis mellitus. Pediatr Pulmonol. 2001; 32:343–350. © 2001 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>cystic fibrosis</subject><subject>Cystic Fibrosis - complications</subject><subject>Cystic Fibrosis - physiopathology</subject><subject>Diabetes Complications</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Forced Expiratory Volume</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>pulmonary function</subject><subject>registry</subject><subject>Vital Capacity</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFv1DAQhSMEokvhwB9AvoDEIa2dxInNDS27BWkpK0Tp0fI6411TJw62o7L_jp-GV4mohMRpDvPNe6P3suwlwRcE4-JyGEZ7QUhVPMoWBHOe44rXj7MFayjNa1aXZ9mzEH5gnHacPM3OCKG8JpQtst9bDwF6BchppI4hGoW02XkXTMg9WBmhRa2RO4gQUAfWmjgGZAKKZn-I9ois6e8SEx0anPPIjv0e6bFX0bgemR4NMhroY0D3Jh7-tXiHPsgokfauQ_EAaDV6N4Ds0WowLXTGWbdP-FfYmxD98fTkclJYzwrPsyda2gAv5nme3axX35Yf882Xq0_L95tclYwXuSaV5MAKzDhjpWKKFi1AGnVbVQW0iuKGtoTrUhdYaSiphCLxGnaU1sDK8-zNpDt493OEEEVngkp5yB7cGERTEMYIqxL4dgJV-i940GLwppP-KAgWp7rEqS5xqiuxr2bRcddB-0DO_STg9QzIoKTVXvbKhAeuIiXn9cn0cuLujYXj_x3Fdnuzma3z6SIFC7_-Xkh_J-qmbKi4vb4St4R-vmbr74KWfwATr8FI</recordid><startdate>200111</startdate><enddate>200111</enddate><creator>Koch, C.</creator><creator>Rainisio, M.</creator><creator>Madessani, U.</creator><creator>Harms, H.K.</creator><creator>Hodson, M.E.</creator><creator>Mastella, G.</creator><creator>McKenzie, S.G.</creator><creator>Navarro, J.</creator><creator>Strandvik, B.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200111</creationdate><title>Presence of cystic fibrosis-related diabetes mellitus is tightly linked to poor lung function in patients with cystic fibrosis: Data from the European Epidemiologic Registry of Cystic Fibrosis</title><author>Koch, C. ; Rainisio, M. ; Madessani, U. ; Harms, H.K. ; Hodson, M.E. ; Mastella, G. ; McKenzie, S.G. ; Navarro, J. ; Strandvik, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3892-f14a9e82089883c8c52dee8c56d442edc5075d19f3f20cfe35ae2e82feb556e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Child</topic><topic>cystic fibrosis</topic><topic>Cystic Fibrosis - complications</topic><topic>Cystic Fibrosis - physiopathology</topic><topic>Diabetes Complications</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Forced Expiratory Volume</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>pulmonary function</topic><topic>registry</topic><topic>Vital Capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koch, C.</creatorcontrib><creatorcontrib>Rainisio, M.</creatorcontrib><creatorcontrib>Madessani, U.</creatorcontrib><creatorcontrib>Harms, H.K.</creatorcontrib><creatorcontrib>Hodson, M.E.</creatorcontrib><creatorcontrib>Mastella, G.</creatorcontrib><creatorcontrib>McKenzie, S.G.</creatorcontrib><creatorcontrib>Navarro, J.</creatorcontrib><creatorcontrib>Strandvik, B.</creatorcontrib><creatorcontrib>Investigators of the European Epidemiologic Registry of Cystic Fibrosis</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koch, C.</au><au>Rainisio, M.</au><au>Madessani, U.</au><au>Harms, H.K.</au><au>Hodson, M.E.</au><au>Mastella, G.</au><au>McKenzie, S.G.</au><au>Navarro, J.</au><au>Strandvik, B.</au><aucorp>Investigators of the European Epidemiologic Registry of Cystic Fibrosis</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presence of cystic fibrosis-related diabetes mellitus is tightly linked to poor lung function in patients with cystic fibrosis: Data from the European Epidemiologic Registry of Cystic Fibrosis</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr. Pulmonol</addtitle><date>2001-11</date><risdate>2001</risdate><volume>32</volume><issue>5</issue><spage>343</spage><epage>350</epage><pages>343-350</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><coden>PEPUES</coden><abstract>Data derived from a cross‐sectional analysis of 7,566 patients stratified into six age groups were used to compare lung function, body mass index (BMI), and weight for age in patients with and without cystic fibrosis‐related diabetes mellitus (CFDM).
The presence of CFDM was tightly linked to poor lung function, regardless of age. The mean value of FEV1 % predicted in the age groups < 10, 10–< 15, 15–< 20, 20–< 25, 25–< 30, and 30 years or older were 87%, 77%, 69%, 58%, 55%, and 53% in the nondiabetic cystic fibrosis (CF) patients as compared to 79%, 66%, 55%, 49%, 46%, and 44% in the diabetic CF patients. BMI and weight for age were also lower in diabetic than nondiabetic CF patients in all age groups, except for BMI in the youngest patients. The difference in lung function and in nutritional parameters between diabetic and nondiabetic CF patients was not linked to presence or absence of any specific pathogen in the lower respiratory tract.
These results confirm and extend those of earlier studies in smaller numbers of patients, and they clearly identify CFDM as a powerful determinant of severe lung disease and reduced survival in patients with CF and diabetis mellitus. Pediatr Pulmonol. 2001; 32:343–350. © 2001 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11596158</pmid><doi>10.1002/ppul.1142</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Biological and medical sciences Body Mass Index Child cystic fibrosis Cystic Fibrosis - complications Cystic Fibrosis - physiopathology Diabetes Complications diabetes mellitus Diabetes Mellitus - physiopathology Forced Expiratory Volume Gastroenterology. Liver. Pancreas. Abdomen Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Other diseases. Semiology pulmonary function registry Vital Capacity |
| title | Presence of cystic fibrosis-related diabetes mellitus is tightly linked to poor lung function in patients with cystic fibrosis: Data from the European Epidemiologic Registry of Cystic Fibrosis |
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