Differential regulation of phosphatidylserine externalization and DNA fragmentation by caspases in anticancer drug-induced apoptosis of rat mammary adenocarcinoma MTLn3 cells

Caspase activation is a central event in the execution phase of apoptosis and is associated with phosphatidylserine (PS) externalization and DNA fragmentation. We investigated the role of caspase activity in anticancer drug-induced PS externalization and DNA fragmentation in MTLn3 cells. Caspase act...

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Veröffentlicht in:	Biochemical pharmacology 2001-10, Vol.62 (8), p.1087-1097
Hauptverfasser:	Huigsloot, Merei, Tijdens, Ine B, Mulder, Gerard J, van de Water, Bob
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Animals Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis Apoptosis - physiology Biological and medical sciences Caspase 3 Caspases Caspases - physiology Cell cycle Cisplatin - pharmacology Cytostatics DNA Fragmentation - drug effects Doxorubicin - pharmacology Etoposide - pharmacology Exocytosis - drug effects General aspects Mammary Neoplasms, Animal - pathology Medical sciences MTLn3 cells Necrosis Pharmacology. Drug treatments Phosphatidylserine Phosphatidylserines - metabolism Rats Tumor Cells, Cultured
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