FDOPA metabolism in the adult porcine brain: influence of tracer circulation time and VOI selection on estimates of striatal DOPA decarboxylation

Different methodologies for PET data analysis influence the magnitude of estimates of blood–brain transfer coefficients and rate constants for the metabolism of FDOPA in living striatum. We now test the effects on several kinetic parameters of automatic procedures for volume of interest (VOI) select...

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Veröffentlicht in:	Journal of neuroscience methods 2001-10, Vol.111 (2), p.157-168
Hauptverfasser:	Danielsen, Erik H, Smith, Donald F, Andersen, Flemming, Gee, Antony D, Bender, Dirk, Hansen, Søren B, Hermansen, Flemming, Østergaard, Leif, Cumming, Paul, Gjedde, Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	6-[ 18F]fluoro- l-3,4-dihydroxyphenylalanine Animals Biological and medical sciences Blood-Brain Barrier Brain - metabolism Corpus Striatum - metabolism Decarboxylation Dihydroxyphenylalanine - analogs & derivatives Dihydroxyphenylalanine - metabolism Dihydroxyphenylalanine - pharmacokinetics FDOPA Female Fluorine Radioisotopes - pharmacokinetics Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Homeostasis Minipig Models, Biological Models, Neurological Neuroimaging Partial volume PET Striatum Swine Swine, Miniature Swine/pigs/porcine Time Factors Vertebrates: nervous system and sense organs
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