Relationship between the extent of histologic villous mineralization and stillbirth in aneuploid and euploid fetuses
To describe the relationship between the degree of placental histologic villous mineralization (VM) and stillbirth in aneuploid and euploid fetuses. The extent of VM for aneuploid and gestational age-matched euploid placentas was graded semiquantitatively on a 0 to 3 scale based on the number of ter...
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| Veröffentlicht in: | Journal of the Society for Gynecologic Investigation 2002-09, Vol.9 (5), p.290-293 |
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| creator | PIERCE, Brian T MARTIN, Laura S HUME, Roderick F CALHOUN, Byron C MUIR-PADILLA, Jeannie SALAFIA, Carolyn M |
| description | To describe the relationship between the degree of placental histologic villous mineralization (VM) and stillbirth in aneuploid and euploid fetuses.
The extent of VM for aneuploid and gestational age-matched euploid placentas was graded semiquantitatively on a 0 to 3 scale based on the number of terminal or stem villi containing mineralizations in forty x10 fields of view. The extent of VM was analyzed in relation to fetal status at delivery (liveborn or stillborn) for both aneuploid and euploid fetuses.
For 14 available aneuploid placentas, grade 0 or 1 VM was recorded for seven aneuploid specimens, of which two were stillborn. Grade 2 or 3 VM was recorded for seven aneuploid specimens, of which six were stillborn. Fourteen gestational age-matched euploid placentas served as controls. Grade 0 or 1 VM was observed in nine euploid specimens, of which four were stillborn. Grade 2 or 3 VM was observed in five euploid specimens, of which four were stillborn. For aneuploid fetuses, stillbirth was significantly more frequent with grade 2 or 3 VM compared with grade 0 or 1 VM (chi(2) = 4.667, P .05).
Histologic VM is not a universal finding in, or exclusive to, stillbirths. Aneuploid but not euploid stillbirths show increased histologic VM compared with livebirths. This may implicate impaired placental or circulatory function as a mechanism for death in aneuploid fetuses. |
| doi_str_mv | 10.1016/S1071-5576(02)00167-3 |
| format | Article |
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The extent of VM for aneuploid and gestational age-matched euploid placentas was graded semiquantitatively on a 0 to 3 scale based on the number of terminal or stem villi containing mineralizations in forty x10 fields of view. The extent of VM was analyzed in relation to fetal status at delivery (liveborn or stillborn) for both aneuploid and euploid fetuses.
For 14 available aneuploid placentas, grade 0 or 1 VM was recorded for seven aneuploid specimens, of which two were stillborn. Grade 2 or 3 VM was recorded for seven aneuploid specimens, of which six were stillborn. Fourteen gestational age-matched euploid placentas served as controls. Grade 0 or 1 VM was observed in nine euploid specimens, of which four were stillborn. Grade 2 or 3 VM was observed in five euploid specimens, of which four were stillborn. For aneuploid fetuses, stillbirth was significantly more frequent with grade 2 or 3 VM compared with grade 0 or 1 VM (chi(2) = 4.667, P <.05). This relationship did not exist for euploid fetuses (chi(2) = 1.659, P >.05).
Histologic VM is not a universal finding in, or exclusive to, stillbirths. Aneuploid but not euploid stillbirths show increased histologic VM compared with livebirths. This may implicate impaired placental or circulatory function as a mechanism for death in aneuploid fetuses.</description><identifier>ISSN: 1071-5576</identifier><identifier>EISSN: 1556-7117</identifier><identifier>DOI: 10.1016/S1071-5576(02)00167-3</identifier><identifier>PMID: 12383913</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Aneuploidy ; Biological and medical sciences ; Chorionic Villi - chemistry ; Chorionic Villi - pathology ; Chromosomes, Human, Pair 10 ; Chromosomes, Human, Pair 13 ; Chromosomes, Human, Pair 18 ; Diseases of mother, fetus and pregnancy ; Down Syndrome - pathology ; Female ; Fetal Death - genetics ; Fetal Death - pathology ; Gene Deletion ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Karyotyping ; Medical sciences ; Minerals - analysis ; Pregnancy ; Pregnancy. Fetus. Placenta ; Trisomy</subject><ispartof>Journal of the Society for Gynecologic Investigation, 2002-09, Vol.9 (5), p.290-293</ispartof><rights>2003 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-4a0d08371969f077272ebecab418ccaf3f03bb5cabd2f12b67f58dde80abe77b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13961959$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12383913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PIERCE, Brian T</creatorcontrib><creatorcontrib>MARTIN, Laura S</creatorcontrib><creatorcontrib>HUME, Roderick F</creatorcontrib><creatorcontrib>CALHOUN, Byron C</creatorcontrib><creatorcontrib>MUIR-PADILLA, Jeannie</creatorcontrib><creatorcontrib>SALAFIA, Carolyn M</creatorcontrib><title>Relationship between the extent of histologic villous mineralization and stillbirth in aneuploid and euploid fetuses</title><title>Journal of the Society for Gynecologic Investigation</title><addtitle>J Soc Gynecol Investig</addtitle><description>To describe the relationship between the degree of placental histologic villous mineralization (VM) and stillbirth in aneuploid and euploid fetuses.
The extent of VM for aneuploid and gestational age-matched euploid placentas was graded semiquantitatively on a 0 to 3 scale based on the number of terminal or stem villi containing mineralizations in forty x10 fields of view. The extent of VM was analyzed in relation to fetal status at delivery (liveborn or stillborn) for both aneuploid and euploid fetuses.
For 14 available aneuploid placentas, grade 0 or 1 VM was recorded for seven aneuploid specimens, of which two were stillborn. Grade 2 or 3 VM was recorded for seven aneuploid specimens, of which six were stillborn. Fourteen gestational age-matched euploid placentas served as controls. Grade 0 or 1 VM was observed in nine euploid specimens, of which four were stillborn. Grade 2 or 3 VM was observed in five euploid specimens, of which four were stillborn. For aneuploid fetuses, stillbirth was significantly more frequent with grade 2 or 3 VM compared with grade 0 or 1 VM (chi(2) = 4.667, P <.05). This relationship did not exist for euploid fetuses (chi(2) = 1.659, P >.05).
Histologic VM is not a universal finding in, or exclusive to, stillbirths. Aneuploid but not euploid stillbirths show increased histologic VM compared with livebirths. This may implicate impaired placental or circulatory function as a mechanism for death in aneuploid fetuses.</description><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>Chorionic Villi - chemistry</subject><subject>Chorionic Villi - pathology</subject><subject>Chromosomes, Human, Pair 10</subject><subject>Chromosomes, Human, Pair 13</subject><subject>Chromosomes, Human, Pair 18</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Down Syndrome - pathology</subject><subject>Female</subject><subject>Fetal Death - genetics</subject><subject>Fetal Death - pathology</subject><subject>Gene Deletion</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Medical sciences</subject><subject>Minerals - analysis</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Trisomy</subject><issn>1071-5576</issn><issn>1556-7117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkElPwzAQhS0EomX5CSBfQHAIeMFxckQVm4SExHK2bGdMjdykxA7br8ctrTjN6M33ZuyH0AElZ5TQ8vyJEkkLIWR5QtgpyZIs-AYaUyHKQlIqN3O_RkZoJ8a3DMns3UYjynjFa8rHKD1C0Ml3bZz6OTaQPgFanKaA4StBm3Dn8NTH1IXu1Vv84UPohohnvoVeB_-z9GLdNjimPDO-T1PsFwoM89D5Zjlb9w7SECHuoS2nQ4T9Vd1FL9dXz5Pb4v7h5m5yeV9YzkUqLjRpSMUlrcvaESmZZGDAanNBK2u1445wY0QWGuYoM6V0omoaqIg2IKXhu-j4b--8794HiEnNfLQQQn5d_oWSjFZSsCqD4g-0fRdjD07Nez_T_beiRC3iVsu41SJLRZhaxq149h2uDgxmBs2_a5VvBo5WgI5WB9fr1vr4z_G6pLWo-S-H14vY</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>PIERCE, Brian T</creator><creator>MARTIN, Laura S</creator><creator>HUME, Roderick F</creator><creator>CALHOUN, Byron C</creator><creator>MUIR-PADILLA, Jeannie</creator><creator>SALAFIA, Carolyn M</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020901</creationdate><title>Relationship between the extent of histologic villous mineralization and stillbirth in aneuploid and euploid fetuses</title><author>PIERCE, Brian T ; MARTIN, Laura S ; HUME, Roderick F ; CALHOUN, Byron C ; MUIR-PADILLA, Jeannie ; SALAFIA, Carolyn M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-4a0d08371969f077272ebecab418ccaf3f03bb5cabd2f12b67f58dde80abe77b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>Chorionic Villi - chemistry</topic><topic>Chorionic Villi - pathology</topic><topic>Chromosomes, Human, Pair 10</topic><topic>Chromosomes, Human, Pair 13</topic><topic>Chromosomes, Human, Pair 18</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Down Syndrome - pathology</topic><topic>Female</topic><topic>Fetal Death - genetics</topic><topic>Fetal Death - pathology</topic><topic>Gene Deletion</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Medical sciences</topic><topic>Minerals - analysis</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Trisomy</topic><toplevel>online_resources</toplevel><creatorcontrib>PIERCE, Brian T</creatorcontrib><creatorcontrib>MARTIN, Laura S</creatorcontrib><creatorcontrib>HUME, Roderick F</creatorcontrib><creatorcontrib>CALHOUN, Byron C</creatorcontrib><creatorcontrib>MUIR-PADILLA, Jeannie</creatorcontrib><creatorcontrib>SALAFIA, Carolyn M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Society for Gynecologic Investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PIERCE, Brian T</au><au>MARTIN, Laura S</au><au>HUME, Roderick F</au><au>CALHOUN, Byron C</au><au>MUIR-PADILLA, Jeannie</au><au>SALAFIA, Carolyn M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between the extent of histologic villous mineralization and stillbirth in aneuploid and euploid fetuses</atitle><jtitle>Journal of the Society for Gynecologic Investigation</jtitle><addtitle>J Soc Gynecol Investig</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>9</volume><issue>5</issue><spage>290</spage><epage>293</epage><pages>290-293</pages><issn>1071-5576</issn><eissn>1556-7117</eissn><abstract>To describe the relationship between the degree of placental histologic villous mineralization (VM) and stillbirth in aneuploid and euploid fetuses.
The extent of VM for aneuploid and gestational age-matched euploid placentas was graded semiquantitatively on a 0 to 3 scale based on the number of terminal or stem villi containing mineralizations in forty x10 fields of view. The extent of VM was analyzed in relation to fetal status at delivery (liveborn or stillborn) for both aneuploid and euploid fetuses.
For 14 available aneuploid placentas, grade 0 or 1 VM was recorded for seven aneuploid specimens, of which two were stillborn. Grade 2 or 3 VM was recorded for seven aneuploid specimens, of which six were stillborn. Fourteen gestational age-matched euploid placentas served as controls. Grade 0 or 1 VM was observed in nine euploid specimens, of which four were stillborn. Grade 2 or 3 VM was observed in five euploid specimens, of which four were stillborn. For aneuploid fetuses, stillbirth was significantly more frequent with grade 2 or 3 VM compared with grade 0 or 1 VM (chi(2) = 4.667, P <.05). This relationship did not exist for euploid fetuses (chi(2) = 1.659, P >.05).
Histologic VM is not a universal finding in, or exclusive to, stillbirths. Aneuploid but not euploid stillbirths show increased histologic VM compared with livebirths. This may implicate impaired placental or circulatory function as a mechanism for death in aneuploid fetuses.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>12383913</pmid><doi>10.1016/S1071-5576(02)00167-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of the Society for Gynecologic Investigation, 2002-09, Vol.9 (5), p.290-293 |
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| subjects | Aneuploidy Biological and medical sciences Chorionic Villi - chemistry Chorionic Villi - pathology Chromosomes, Human, Pair 10 Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 18 Diseases of mother, fetus and pregnancy Down Syndrome - pathology Female Fetal Death - genetics Fetal Death - pathology Gene Deletion Gestational Age Gynecology. Andrology. Obstetrics Humans Karyotyping Medical sciences Minerals - analysis Pregnancy Pregnancy. Fetus. Placenta Trisomy |
| title | Relationship between the extent of histologic villous mineralization and stillbirth in aneuploid and euploid fetuses |
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