CTLA-4 gene polymorphisms in systemic lupus erythematosus: a highly significant association with a determinant in the promoter region

The cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4; CD 152) is a negative regulator of T-lymphocyte activation. Particular genotypes of the locus encoding the CTLA-4 glycoprotein have been associated with susceptibility to various autoimmune diseases. To determine their role in susceptibility t...

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Veröffentlicht in:	Human genetics 2002-10, Vol.111 (4-5), p.452-455
Hauptverfasser:	HUDSON, Lori L, ROCCA, Keith, SONG, Yeong W, PANDEY, Janardan P
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Adolescent Adult Aged Antigens, CD Antigens, Differentiation - genetics Base Sequence Biological and medical sciences CTLA-4 Antigen Dermatology DNA Primers Female General aspects Genotype Humans Immunoconjugates Immunopathology Lupus Erythematosus, Systemic - genetics Male Medical sciences Middle Aged Polymorphism, Genetic Promoter Regions, Genetic Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin involvement in other diseases. Miscellaneous. General aspects
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