Frequent alteration of MDM2 and p53 in the molecular progression of recurring non-Hodgkin's lymphoma

Aims: Recurrence of non‐Hodgkin's lymphoma with or without transformation is often associated with increased clinical drug resistance and poor prognosis indicating molecular progression. The study addresses the currently poorly understood molecular mechanisms underlying relapsing non‐Hodgkin�...

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Veröffentlicht in:	Histopathology 2002-10, Vol.41 (4), p.322-330
Hauptverfasser:	Møller, M B, Nielsen, O, Pedersen, N T
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor Cell Cycle Proteins - biosynthesis Cell Transformation, Neoplastic - genetics Cyclin D3 Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p27 Cyclins - biosynthesis Disease Progression Female Genes, p53 - genetics Hematologic and hematopoietic diseases Humans Immunohistochemistry Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, B-Cell - genetics Lymphoma, B-Cell - metabolism Lymphoma, B-Cell - pathology Lymphoma, Follicular - genetics Lymphoma, Follicular - metabolism Lymphoma, Follicular - pathology Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - metabolism Lymphoma, Large B-Cell, Diffuse - pathology Lymphoma, Non-Hodgkin - genetics Lymphoma, Non-Hodgkin - metabolism Lymphoma, Non-Hodgkin - pathology Lymphoma, T-Cell - genetics Lymphoma, T-Cell - metabolism Lymphoma, T-Cell - pathology Male MDM2 Medical sciences Mutation non-Hodgkin's lymphoma Nuclear Proteins p27Kip1 p53 progression Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins c-mdm2 Recurrence relapse transformation Tumor Suppressor Proteins - biosynthesis
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