Effect of skin disinfection with octenidine dihydrochloride on insertion site colonization of intravascular catheters
We investigated the efficacy of two commercially available, alcohol-based antiseptic solutions in decontaminating the insertion site of central lines. One solution contained the bispyridine octenidine dihydrochloride. Inpatients receiving either a central venous catheter (CVC) or a peripherally inse...
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| Veröffentlicht in: | Infection 2002-10, Vol.30 (5), p.282-285 |
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| creator | DETTENKOFER, M JONAS, D WIECHMANN, C ROSSNER, R FRANK, U ZENTNER, J DASCHNER, F. D |
| description | We investigated the efficacy of two commercially available, alcohol-based antiseptic solutions in decontaminating the insertion site of central lines. One solution contained the bispyridine octenidine dihydrochloride.
Inpatients receiving either a central venous catheter (CVC) or a peripherally inserted central catheter (PICC) were alternately assigned to different skin disinfection regimens at the insertion site: (A) 0.1% octendine dihydrochloride with 30% 1-propanol and 45% 2-propanol, (B) 74% ethanol with 10% 2-propanol. Quantitative skin cultures were obtained from the insertion site at predetermined intervals.
A total of 60 patients received 12 CVCs and 47 PICCs (no significant difference with respect to gender, age and catheter type). In total, 90 cultures were assessed in each group. The median colony-forming unit (cfu) counts per 24 cm(2) (group A vs B) were 2,270 vs 2,950 before, 20 vs 40 following and 860 vs 1,210 24 h after catheter insertion, respectively. A statistically significant difference in the efficacy of skin decontamination was seen between groups in culture set (3) and in the difference between culture sets (2) and (3) (Wilcoxon rank sum test).
Octenidine/propanol appears to be more effective than alcohol (ethanol/propanol) alone in reducing microflora of the skin at the PICC/CVC insertion site over a 24-h period. |
| doi_str_mv | 10.1007/s15010-002-2182-2 |
| format | Article |
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Inpatients receiving either a central venous catheter (CVC) or a peripherally inserted central catheter (PICC) were alternately assigned to different skin disinfection regimens at the insertion site: (A) 0.1% octendine dihydrochloride with 30% 1-propanol and 45% 2-propanol, (B) 74% ethanol with 10% 2-propanol. Quantitative skin cultures were obtained from the insertion site at predetermined intervals.
A total of 60 patients received 12 CVCs and 47 PICCs (no significant difference with respect to gender, age and catheter type). In total, 90 cultures were assessed in each group. The median colony-forming unit (cfu) counts per 24 cm(2) (group A vs B) were 2,270 vs 2,950 before, 20 vs 40 following and 860 vs 1,210 24 h after catheter insertion, respectively. A statistically significant difference in the efficacy of skin decontamination was seen between groups in culture set (3) and in the difference between culture sets (2) and (3) (Wilcoxon rank sum test).
Octenidine/propanol appears to be more effective than alcohol (ethanol/propanol) alone in reducing microflora of the skin at the PICC/CVC insertion site over a 24-h period.</description><identifier>ISSN: 0300-8126</identifier><identifier>EISSN: 1439-0973</identifier><identifier>DOI: 10.1007/s15010-002-2182-2</identifier><identifier>PMID: 12382087</identifier><identifier>CODEN: IFTNAL</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>1-Propanol - pharmacology ; Anti-Infective Agents, Local - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiseptics ; Bacterial Infections - prevention & control ; Biological and medical sciences ; Catheterization, Central Venous - methods ; Catheterization, Peripheral - methods ; Decontamination ; Disinfection ; Disinfection - methods ; Drug Therapy, Combination ; Equipment Contamination - prevention & control ; Ethanol ; Ethanol - pharmacology ; Female ; Humans ; Male ; Medical instruments ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Probability ; Prospective Studies ; Pyridines - pharmacology ; Sensitivity and Specificity ; Skin ; Skin - drug effects ; Skin - microbiology ; Statistics, Nonparametric</subject><ispartof>Infection, 2002-10, Vol.30 (5), p.282-285</ispartof><rights>2002 INIST-CNRS</rights><rights>Urban & Vogel Medien und Medizin Verlagsgesellschaft 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-afeb18cfebc99b429c9e3a1befe7ac2ef036804f8af8f784b970325ae4c6234c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13949786$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12382087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DETTENKOFER, M</creatorcontrib><creatorcontrib>JONAS, D</creatorcontrib><creatorcontrib>WIECHMANN, C</creatorcontrib><creatorcontrib>ROSSNER, R</creatorcontrib><creatorcontrib>FRANK, U</creatorcontrib><creatorcontrib>ZENTNER, J</creatorcontrib><creatorcontrib>DASCHNER, F. D</creatorcontrib><title>Effect of skin disinfection with octenidine dihydrochloride on insertion site colonization of intravascular catheters</title><title>Infection</title><addtitle>Infection</addtitle><description>We investigated the efficacy of two commercially available, alcohol-based antiseptic solutions in decontaminating the insertion site of central lines. One solution contained the bispyridine octenidine dihydrochloride.
Inpatients receiving either a central venous catheter (CVC) or a peripherally inserted central catheter (PICC) were alternately assigned to different skin disinfection regimens at the insertion site: (A) 0.1% octendine dihydrochloride with 30% 1-propanol and 45% 2-propanol, (B) 74% ethanol with 10% 2-propanol. Quantitative skin cultures were obtained from the insertion site at predetermined intervals.
A total of 60 patients received 12 CVCs and 47 PICCs (no significant difference with respect to gender, age and catheter type). In total, 90 cultures were assessed in each group. The median colony-forming unit (cfu) counts per 24 cm(2) (group A vs B) were 2,270 vs 2,950 before, 20 vs 40 following and 860 vs 1,210 24 h after catheter insertion, respectively. A statistically significant difference in the efficacy of skin decontamination was seen between groups in culture set (3) and in the difference between culture sets (2) and (3) (Wilcoxon rank sum test).
Octenidine/propanol appears to be more effective than alcohol (ethanol/propanol) alone in reducing microflora of the skin at the PICC/CVC insertion site over a 24-h period.</description><subject>1-Propanol - pharmacology</subject><subject>Anti-Infective Agents, Local - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiseptics</subject><subject>Bacterial Infections - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Catheterization, Central Venous - methods</subject><subject>Catheterization, Peripheral - methods</subject><subject>Decontamination</subject><subject>Disinfection</subject><subject>Disinfection - methods</subject><subject>Drug Therapy, Combination</subject><subject>Equipment Contamination - prevention & control</subject><subject>Ethanol</subject><subject>Ethanol - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical instruments</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Probability</subject><subject>Prospective Studies</subject><subject>Pyridines - pharmacology</subject><subject>Sensitivity and Specificity</subject><subject>Skin</subject><subject>Skin - drug effects</subject><subject>Skin - microbiology</subject><subject>Statistics, Nonparametric</subject><issn>0300-8126</issn><issn>1439-0973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU1r3DAQhkVpaTZpf0AvxRSam5PRhy3pWEL6AYFemrOQ5RGr1CulktyQ_PpqswuBXkYweuZlmIeQDxQuKIC8LHQACj0A6xlVrbwiGyq47kFL_ppsgAP0irLxhJyWcgcAgxbyLTmhjCsGSm7Ieu09utol35XfIXZzKCHuOyHF7iHUbZdcxRjmELF9bh_nnNx2STnM2DUkxIL5GS6hYufSkmJ4ss-dlhlizfavLW5dbO6crVusmMs78sbbpeD743tGbr9e_7r63t_8_Pbj6stN7_ggam89TlS5Vp3Wk2DaaeSWTuhRWsfQAx8VCK-sV14qMWkJnA0WhRsZF46fkfND7n1Of1Ys1exCcbgsNmJai5HtbKMA3cBP_4F3ac2x7WYYHUaqRy0aRA-Qy6mUjN7c57Cz-dFQMHsh5iDENCFmL8SwNvPxGLxOO5xfJo4GGvD5CLQr2cVnG10oLxzXQks18n9JtJZp</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>DETTENKOFER, M</creator><creator>JONAS, D</creator><creator>WIECHMANN, C</creator><creator>ROSSNER, R</creator><creator>FRANK, U</creator><creator>ZENTNER, J</creator><creator>DASCHNER, F. 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D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of skin disinfection with octenidine dihydrochloride on insertion site colonization of intravascular catheters</atitle><jtitle>Infection</jtitle><addtitle>Infection</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>30</volume><issue>5</issue><spage>282</spage><epage>285</epage><pages>282-285</pages><issn>0300-8126</issn><eissn>1439-0973</eissn><coden>IFTNAL</coden><abstract>We investigated the efficacy of two commercially available, alcohol-based antiseptic solutions in decontaminating the insertion site of central lines. One solution contained the bispyridine octenidine dihydrochloride.
Inpatients receiving either a central venous catheter (CVC) or a peripherally inserted central catheter (PICC) were alternately assigned to different skin disinfection regimens at the insertion site: (A) 0.1% octendine dihydrochloride with 30% 1-propanol and 45% 2-propanol, (B) 74% ethanol with 10% 2-propanol. Quantitative skin cultures were obtained from the insertion site at predetermined intervals.
A total of 60 patients received 12 CVCs and 47 PICCs (no significant difference with respect to gender, age and catheter type). In total, 90 cultures were assessed in each group. The median colony-forming unit (cfu) counts per 24 cm(2) (group A vs B) were 2,270 vs 2,950 before, 20 vs 40 following and 860 vs 1,210 24 h after catheter insertion, respectively. A statistically significant difference in the efficacy of skin decontamination was seen between groups in culture set (3) and in the difference between culture sets (2) and (3) (Wilcoxon rank sum test).
Octenidine/propanol appears to be more effective than alcohol (ethanol/propanol) alone in reducing microflora of the skin at the PICC/CVC insertion site over a 24-h period.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>12382087</pmid><doi>10.1007/s15010-002-2182-2</doi><tpages>4</tpages></addata></record> |
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| subjects | 1-Propanol - pharmacology Anti-Infective Agents, Local - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiseptics Bacterial Infections - prevention & control Biological and medical sciences Catheterization, Central Venous - methods Catheterization, Peripheral - methods Decontamination Disinfection Disinfection - methods Drug Therapy, Combination Equipment Contamination - prevention & control Ethanol Ethanol - pharmacology Female Humans Male Medical instruments Medical sciences Middle Aged Pharmacology. Drug treatments Probability Prospective Studies Pyridines - pharmacology Sensitivity and Specificity Skin Skin - drug effects Skin - microbiology Statistics, Nonparametric |
| title | Effect of skin disinfection with octenidine dihydrochloride on insertion site colonization of intravascular catheters |
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