Effects of electrical stimulation-induced leg training on skeletal muscle adaptability in spinal cord injury
Neuromuscular electrical stimulation has grown in popularity as a therapeutic device for training and an ambulation aid to human paralyzed muscle. Despite its current clinical use, few studies have attempted to concurrently investigate the functional and intramuscular adaptations which occur after e...
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| Veröffentlicht in: | Scandinavian journal of medicine & science in sports 2002-10, Vol.12 (5), p.316-322 |
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| creator | Crameri, R. M. Weston, A. Climstein, M. Davis, G. M. Sutton, J. R. |
| description | Neuromuscular electrical stimulation has grown in popularity as a therapeutic device for training and an ambulation aid to human paralyzed muscle. Despite its current clinical use, few studies have attempted to concurrently investigate the functional and intramuscular adaptations which occur after electrical stimulation training. Six individuals with a spinal cord injury performed 10 weeks of electrical stimulation leg cycle training (30 min d−1, 3 d week−1). The paralyzed vastus lateralis muscle showed significant alterations in skeletal muscle characteristics after the training, indicated by an improvement in total work output (52–112 kJ; P |
| doi_str_mv | 10.1034/j.1600-0838.2002.20106.x |
| format | Article |
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The paralyzed vastus lateralis muscle showed significant alterations in skeletal muscle characteristics after the training, indicated by an improvement in total work output (52–112 kJ; P < 0.05), an increase in fiber cross‐sectional area (18 to 41 × 102 µm2; P < 0.05), a reduction in the percentage of type IIX fibers (75% to 12%; P < 0.05), a decrease in myosin heavy chain IIx (68% to 44%; P < 0.05), an increase in capillary density (2–3.5 capillaries around fiber; P < 0.05) and increases in activity levels of citrate synthase (7–16 mU mg−1 protein) and hexokinase (1.2–2.4 mU mg−1 protein). This study showed that 10 weeks of electrical stimulation training of human paralyzed muscle induces concurrent improvements in functional capacity and oxidative metabolism.</description><identifier>ISSN: 0905-7188</identifier><identifier>EISSN: 1600-0838</identifier><identifier>DOI: 10.1034/j.1600-0838.2002.20106.x</identifier><identifier>PMID: 12383078</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Adaptation, Physiological ; Adult ; Biological and medical sciences ; capillarization ; Diseases of the nervous system ; Electric Stimulation Therapy ; Energy Metabolism ; exercise ; Female ; fiber type ; function ; Humans ; Leg - physiology ; Male ; Medical sciences ; morphology ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - physiopathology ; Muscular Atrophy - physiopathology ; paraplegic ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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M.</creatorcontrib><creatorcontrib>Weston, A.</creatorcontrib><creatorcontrib>Climstein, M.</creatorcontrib><creatorcontrib>Davis, G. M.</creatorcontrib><creatorcontrib>Sutton, J. R.</creatorcontrib><title>Effects of electrical stimulation-induced leg training on skeletal muscle adaptability in spinal cord injury</title><title>Scandinavian journal of medicine & science in sports</title><addtitle>Scand J Med Sci Sports</addtitle><description>Neuromuscular electrical stimulation has grown in popularity as a therapeutic device for training and an ambulation aid to human paralyzed muscle. Despite its current clinical use, few studies have attempted to concurrently investigate the functional and intramuscular adaptations which occur after electrical stimulation training. Six individuals with a spinal cord injury performed 10 weeks of electrical stimulation leg cycle training (30 min d−1, 3 d week−1). The paralyzed vastus lateralis muscle showed significant alterations in skeletal muscle characteristics after the training, indicated by an improvement in total work output (52–112 kJ; P < 0.05), an increase in fiber cross‐sectional area (18 to 41 × 102 µm2; P < 0.05), a reduction in the percentage of type IIX fibers (75% to 12%; P < 0.05), a decrease in myosin heavy chain IIx (68% to 44%; P < 0.05), an increase in capillary density (2–3.5 capillaries around fiber; P < 0.05) and increases in activity levels of citrate synthase (7–16 mU mg−1 protein) and hexokinase (1.2–2.4 mU mg−1 protein). This study showed that 10 weeks of electrical stimulation training of human paralyzed muscle induces concurrent improvements in functional capacity and oxidative metabolism.</description><subject>Adaptation, Physiological</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>capillarization</subject><subject>Diseases of the nervous system</subject><subject>Electric Stimulation Therapy</subject><subject>Energy Metabolism</subject><subject>exercise</subject><subject>Female</subject><subject>fiber type</subject><subject>function</subject><subject>Humans</subject><subject>Leg - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>morphology</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Muscular Atrophy - physiopathology</subject><subject>paraplegic</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Spinal Cord Injuries - physiopathology</subject><subject>Spinal Cord Injuries - rehabilitation</subject><issn>0905-7188</issn><issn>1600-0838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EokvhKyBf4JZlHCe294KEtn9AKkWiRT1ajjOpvHWSxXbE7rfH6a7aI1zsseb33ljzCKEMlgx49WmzZAKgAMXVsgQo88FALHcvyOKp8ZIsYAV1IZlSJ-RNjBsAJldV_ZqcsJIrDlItiD_vOrQp0rGj6HMVnDWexuT6yZvkxqFwQztZbKnHe5qCcYMb7uk40PiQBSnD_RStR2pas02mcd6lPXW5v3VD7toxtPm5mcL-LXnVGR_x3fE-Jb8uzm_XX4urH5ff1l-uCltzJgrFmbGAtWIVYteAMXXZWMkZAhNNueJSSOS8KlsJSqFgnbBGtVCVWYTK8FPy8eC7DePvCWPSvYsWvTcDjlPUsmRKgKz_CWYsz-EzqA6gDWOMATu9Da43Ya8Z6DkSvdHz5vW8eT1Hoh8j0bssfX-cMTU9ts_CYwYZ-HAETMy774IZrIvPHF9JDmWVuc8H7o_zuP_vD-ib7zePZTYoDgYuJtw9GZjwoIXkstZ315f6bM1_wu3Fnb7mfwHcd7dQ</recordid><startdate>200210</startdate><enddate>200210</enddate><creator>Crameri, R. M.</creator><creator>Weston, A.</creator><creator>Climstein, M.</creator><creator>Davis, G. M.</creator><creator>Sutton, J. R.</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>200210</creationdate><title>Effects of electrical stimulation-induced leg training on skeletal muscle adaptability in spinal cord injury</title><author>Crameri, R. M. ; Weston, A. ; Climstein, M. ; Davis, G. M. ; Sutton, J. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5316-831ac0e5814eefb0aa52bc731e016b293767e3342d7088e61f6ca8d0420e5e8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adaptation, Physiological</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>capillarization</topic><topic>Diseases of the nervous system</topic><topic>Electric Stimulation Therapy</topic><topic>Energy Metabolism</topic><topic>exercise</topic><topic>Female</topic><topic>fiber type</topic><topic>function</topic><topic>Humans</topic><topic>Leg - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>morphology</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Muscular Atrophy - physiopathology</topic><topic>paraplegic</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Spinal Cord Injuries - physiopathology</topic><topic>Spinal Cord Injuries - rehabilitation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crameri, R. M.</creatorcontrib><creatorcontrib>Weston, A.</creatorcontrib><creatorcontrib>Climstein, M.</creatorcontrib><creatorcontrib>Davis, G. M.</creatorcontrib><creatorcontrib>Sutton, J. 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R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of electrical stimulation-induced leg training on skeletal muscle adaptability in spinal cord injury</atitle><jtitle>Scandinavian journal of medicine & science in sports</jtitle><addtitle>Scand J Med Sci Sports</addtitle><date>2002-10</date><risdate>2002</risdate><volume>12</volume><issue>5</issue><spage>316</spage><epage>322</epage><pages>316-322</pages><issn>0905-7188</issn><eissn>1600-0838</eissn><abstract>Neuromuscular electrical stimulation has grown in popularity as a therapeutic device for training and an ambulation aid to human paralyzed muscle. Despite its current clinical use, few studies have attempted to concurrently investigate the functional and intramuscular adaptations which occur after electrical stimulation training. Six individuals with a spinal cord injury performed 10 weeks of electrical stimulation leg cycle training (30 min d−1, 3 d week−1). The paralyzed vastus lateralis muscle showed significant alterations in skeletal muscle characteristics after the training, indicated by an improvement in total work output (52–112 kJ; P < 0.05), an increase in fiber cross‐sectional area (18 to 41 × 102 µm2; P < 0.05), a reduction in the percentage of type IIX fibers (75% to 12%; P < 0.05), a decrease in myosin heavy chain IIx (68% to 44%; P < 0.05), an increase in capillary density (2–3.5 capillaries around fiber; P < 0.05) and increases in activity levels of citrate synthase (7–16 mU mg−1 protein) and hexokinase (1.2–2.4 mU mg−1 protein). This study showed that 10 weeks of electrical stimulation training of human paralyzed muscle induces concurrent improvements in functional capacity and oxidative metabolism.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>12383078</pmid><doi>10.1034/j.1600-0838.2002.20106.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Scandinavian journal of medicine & science in sports, 2002-10, Vol.12 (5), p.316-322 |
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| subjects | Adaptation, Physiological Adult Biological and medical sciences capillarization Diseases of the nervous system Electric Stimulation Therapy Energy Metabolism exercise Female fiber type function Humans Leg - physiology Male Medical sciences morphology Muscle, Skeletal - metabolism Muscle, Skeletal - physiopathology Muscular Atrophy - physiopathology paraplegic Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Spinal Cord Injuries - physiopathology Spinal Cord Injuries - rehabilitation |
| title | Effects of electrical stimulation-induced leg training on skeletal muscle adaptability in spinal cord injury |
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