Age-related alterations in responses of Nucleus basalis magnocellularis neurons to peripheral nociceptive stimuli
The present study investigated the effects of peripheral noxious stimuli on the spontaneous activity of the nucleus basalis magnocellularis (nbM) neurons in young, adult and old rats. Single unit extracellular recordings from the nbM neurons were obtained with glass micropipettes in urethane-anesthe...
Gespeichert in:
| Veröffentlicht in: | Brain research 2002-09, Vol.948 (1), p.47-55 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 55 |
|---|---|
| container_issue | 1 |
| container_start_page | 47 |
| container_title | Brain research |
| container_volume | 948 |
| creator | Zhang, Yu-Qiu Mei, Jun Lü, Shao-Gang Zhao, Zhi-Qi |
| description | The present study investigated the effects of peripheral noxious stimuli on the spontaneous activity of the nucleus basalis magnocellularis (nbM) neurons in young, adult and old rats. Single unit extracellular recordings from the nbM neurons were obtained with glass micropipettes in urethane-anesthetized rats. A total of 104 units were antidromically identified as nbM-cortical neurons. Noxious but not innocuous mechanical stimulation elicited responses in 72% of the 104 neurons. Most of them were excited. The receptive fields were usually very large and bilateral. Most of the neurons also responded to noxious thermal, chemical and electrical stimuli. No marked differences were observed in the incidence of neurons having different spontaneous firing rates, firing patterns and response type among the three age groups. However, the latency of responses evoked by noxious thermal or electrical stimulation and the threshold of excitatory responses evoked by electrical stimulation were increased with aging. The duration and peak-firing rate of excitatory responses evoked by noxious thermal, chemical or electrical stimulation were decreased in old rats. These findings indicate that there might be some functional changes in the nbM neurons and its projection pathway with aging, which impair their responsive ability to peripheral nociceptive stimuli. |
| doi_str_mv | 10.1016/S0006-8993(02)02947-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72186059</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006899302029475</els_id><sourcerecordid>72186059</sourcerecordid><originalsourceid>FETCH-LOGICAL-c422t-7bc2e83c03a8fc017cf273c6c0323165584985f264967db99ce3e787d714d7da3</originalsourceid><addsrcrecordid>eNqFkUtP3TAQha2qFVwoP6GVN0WwSOtHEtsrhBDQSqhdtF1bvs6EunIeeByk_nsc7lVZspoZ6zvHozmEfODsM2e8_fKTMdZW2hh5xsQ5E6ZWVfOGbLhWompFzd6SzX_kkBwh_i2jlIYdkEMupJamqTfk4fIeqgTRZeioixmSy2EakYaRJsC5tIB06un3xUdYkG4duhiQDu5-nDzEuESXyjzCklZdnugMKcx_ilOkBQke5hwegWIOwxLDe_KudxHhZF-Pye-b619XX6u7H7ffri7vKl8LkSu19QK09Ew63XvGle-Fkr4tD0Lytml0bXTTi7Y2req2xniQoLTqFK871Tl5TE53vnOaHhbAbIeA68JuhGlBqwTXLWvMq-CKKclVAZsd6NOEmKC3cwqDS_8sZ3YNxT6HYteLWybscyi2KbqP-w-W7QDdi2qfQgE-7QGH3sU-udEHfOFkceRGF-5ix0G522OAZNEHGD10IYHPtpvCK6s8AcS3qsM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18607317</pqid></control><display><type>article</type><title>Age-related alterations in responses of Nucleus basalis magnocellularis neurons to peripheral nociceptive stimuli</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Zhang, Yu-Qiu ; Mei, Jun ; Lü, Shao-Gang ; Zhao, Zhi-Qi</creator><creatorcontrib>Zhang, Yu-Qiu ; Mei, Jun ; Lü, Shao-Gang ; Zhao, Zhi-Qi</creatorcontrib><description>The present study investigated the effects of peripheral noxious stimuli on the spontaneous activity of the nucleus basalis magnocellularis (nbM) neurons in young, adult and old rats. Single unit extracellular recordings from the nbM neurons were obtained with glass micropipettes in urethane-anesthetized rats. A total of 104 units were antidromically identified as nbM-cortical neurons. Noxious but not innocuous mechanical stimulation elicited responses in 72% of the 104 neurons. Most of them were excited. The receptive fields were usually very large and bilateral. Most of the neurons also responded to noxious thermal, chemical and electrical stimuli. No marked differences were observed in the incidence of neurons having different spontaneous firing rates, firing patterns and response type among the three age groups. However, the latency of responses evoked by noxious thermal or electrical stimulation and the threshold of excitatory responses evoked by electrical stimulation were increased with aging. The duration and peak-firing rate of excitatory responses evoked by noxious thermal, chemical or electrical stimulation were decreased in old rats. These findings indicate that there might be some functional changes in the nbM neurons and its projection pathway with aging, which impair their responsive ability to peripheral nociceptive stimuli.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(02)02947-5</identifier><identifier>PMID: 12383954</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Aging ; Aging - physiology ; Animals ; Basal Nucleus of Meynert - cytology ; Basal Nucleus of Meynert - physiology ; Biological and medical sciences ; Development. Senescence. Regeneration. Transplantation ; Electroshock ; Evoked Potentials - drug effects ; Evoked Potentials - physiology ; Fundamental and applied biological sciences. Psychology ; Hot Temperature ; Male ; Neurons - physiology ; Noxious stimulus ; Nucleus basalis of magnocellularis ; Pain Measurement - methods ; Peripheral Nervous System - drug effects ; Peripheral Nervous System - physiology ; Physical Stimulation ; Potassium Chloride - pharmacology ; Rat ; Rats ; Rats, Sprague-Dawley ; Reaction Time - drug effects ; Reaction Time - physiology ; Stimulation, Chemical ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 2002-09, Vol.948 (1), p.47-55</ispartof><rights>2002 Elsevier Science B.V.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-7bc2e83c03a8fc017cf273c6c0323165584985f264967db99ce3e787d714d7da3</citedby><cites>FETCH-LOGICAL-c422t-7bc2e83c03a8fc017cf273c6c0323165584985f264967db99ce3e787d714d7da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-8993(02)02947-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13899198$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12383954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yu-Qiu</creatorcontrib><creatorcontrib>Mei, Jun</creatorcontrib><creatorcontrib>Lü, Shao-Gang</creatorcontrib><creatorcontrib>Zhao, Zhi-Qi</creatorcontrib><title>Age-related alterations in responses of Nucleus basalis magnocellularis neurons to peripheral nociceptive stimuli</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The present study investigated the effects of peripheral noxious stimuli on the spontaneous activity of the nucleus basalis magnocellularis (nbM) neurons in young, adult and old rats. Single unit extracellular recordings from the nbM neurons were obtained with glass micropipettes in urethane-anesthetized rats. A total of 104 units were antidromically identified as nbM-cortical neurons. Noxious but not innocuous mechanical stimulation elicited responses in 72% of the 104 neurons. Most of them were excited. The receptive fields were usually very large and bilateral. Most of the neurons also responded to noxious thermal, chemical and electrical stimuli. No marked differences were observed in the incidence of neurons having different spontaneous firing rates, firing patterns and response type among the three age groups. However, the latency of responses evoked by noxious thermal or electrical stimulation and the threshold of excitatory responses evoked by electrical stimulation were increased with aging. The duration and peak-firing rate of excitatory responses evoked by noxious thermal, chemical or electrical stimulation were decreased in old rats. These findings indicate that there might be some functional changes in the nbM neurons and its projection pathway with aging, which impair their responsive ability to peripheral nociceptive stimuli.</description><subject>Aging</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Basal Nucleus of Meynert - cytology</subject><subject>Basal Nucleus of Meynert - physiology</subject><subject>Biological and medical sciences</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Electroshock</subject><subject>Evoked Potentials - drug effects</subject><subject>Evoked Potentials - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hot Temperature</subject><subject>Male</subject><subject>Neurons - physiology</subject><subject>Noxious stimulus</subject><subject>Nucleus basalis of magnocellularis</subject><subject>Pain Measurement - methods</subject><subject>Peripheral Nervous System - drug effects</subject><subject>Peripheral Nervous System - physiology</subject><subject>Physical Stimulation</subject><subject>Potassium Chloride - pharmacology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reaction Time - drug effects</subject><subject>Reaction Time - physiology</subject><subject>Stimulation, Chemical</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtP3TAQha2qFVwoP6GVN0WwSOtHEtsrhBDQSqhdtF1bvs6EunIeeByk_nsc7lVZspoZ6zvHozmEfODsM2e8_fKTMdZW2hh5xsQ5E6ZWVfOGbLhWompFzd6SzX_kkBwh_i2jlIYdkEMupJamqTfk4fIeqgTRZeioixmSy2EakYaRJsC5tIB06un3xUdYkG4duhiQDu5-nDzEuESXyjzCklZdnugMKcx_ilOkBQke5hwegWIOwxLDe_KudxHhZF-Pye-b619XX6u7H7ffri7vKl8LkSu19QK09Ew63XvGle-Fkr4tD0Lytml0bXTTi7Y2req2xniQoLTqFK871Tl5TE53vnOaHhbAbIeA68JuhGlBqwTXLWvMq-CKKclVAZsd6NOEmKC3cwqDS_8sZ3YNxT6HYteLWybscyi2KbqP-w-W7QDdi2qfQgE-7QGH3sU-udEHfOFkceRGF-5ix0G522OAZNEHGD10IYHPtpvCK6s8AcS3qsM</recordid><startdate>20020906</startdate><enddate>20020906</enddate><creator>Zhang, Yu-Qiu</creator><creator>Mei, Jun</creator><creator>Lü, Shao-Gang</creator><creator>Zhao, Zhi-Qi</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20020906</creationdate><title>Age-related alterations in responses of Nucleus basalis magnocellularis neurons to peripheral nociceptive stimuli</title><author>Zhang, Yu-Qiu ; Mei, Jun ; Lü, Shao-Gang ; Zhao, Zhi-Qi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-7bc2e83c03a8fc017cf273c6c0323165584985f264967db99ce3e787d714d7da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aging</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Basal Nucleus of Meynert - cytology</topic><topic>Basal Nucleus of Meynert - physiology</topic><topic>Biological and medical sciences</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Electroshock</topic><topic>Evoked Potentials - drug effects</topic><topic>Evoked Potentials - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hot Temperature</topic><topic>Male</topic><topic>Neurons - physiology</topic><topic>Noxious stimulus</topic><topic>Nucleus basalis of magnocellularis</topic><topic>Pain Measurement - methods</topic><topic>Peripheral Nervous System - drug effects</topic><topic>Peripheral Nervous System - physiology</topic><topic>Physical Stimulation</topic><topic>Potassium Chloride - pharmacology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reaction Time - drug effects</topic><topic>Reaction Time - physiology</topic><topic>Stimulation, Chemical</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yu-Qiu</creatorcontrib><creatorcontrib>Mei, Jun</creatorcontrib><creatorcontrib>Lü, Shao-Gang</creatorcontrib><creatorcontrib>Zhao, Zhi-Qi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yu-Qiu</au><au>Mei, Jun</au><au>Lü, Shao-Gang</au><au>Zhao, Zhi-Qi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related alterations in responses of Nucleus basalis magnocellularis neurons to peripheral nociceptive stimuli</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2002-09-06</date><risdate>2002</risdate><volume>948</volume><issue>1</issue><spage>47</spage><epage>55</epage><pages>47-55</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The present study investigated the effects of peripheral noxious stimuli on the spontaneous activity of the nucleus basalis magnocellularis (nbM) neurons in young, adult and old rats. Single unit extracellular recordings from the nbM neurons were obtained with glass micropipettes in urethane-anesthetized rats. A total of 104 units were antidromically identified as nbM-cortical neurons. Noxious but not innocuous mechanical stimulation elicited responses in 72% of the 104 neurons. Most of them were excited. The receptive fields were usually very large and bilateral. Most of the neurons also responded to noxious thermal, chemical and electrical stimuli. No marked differences were observed in the incidence of neurons having different spontaneous firing rates, firing patterns and response type among the three age groups. However, the latency of responses evoked by noxious thermal or electrical stimulation and the threshold of excitatory responses evoked by electrical stimulation were increased with aging. The duration and peak-firing rate of excitatory responses evoked by noxious thermal, chemical or electrical stimulation were decreased in old rats. These findings indicate that there might be some functional changes in the nbM neurons and its projection pathway with aging, which impair their responsive ability to peripheral nociceptive stimuli.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>12383954</pmid><doi>10.1016/S0006-8993(02)02947-5</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 2002-09, Vol.948 (1), p.47-55 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72186059 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aging Aging - physiology Animals Basal Nucleus of Meynert - cytology Basal Nucleus of Meynert - physiology Biological and medical sciences Development. Senescence. Regeneration. Transplantation Electroshock Evoked Potentials - drug effects Evoked Potentials - physiology Fundamental and applied biological sciences. Psychology Hot Temperature Male Neurons - physiology Noxious stimulus Nucleus basalis of magnocellularis Pain Measurement - methods Peripheral Nervous System - drug effects Peripheral Nervous System - physiology Physical Stimulation Potassium Chloride - pharmacology Rat Rats Rats, Sprague-Dawley Reaction Time - drug effects Reaction Time - physiology Stimulation, Chemical Vertebrates: nervous system and sense organs |
| title | Age-related alterations in responses of Nucleus basalis magnocellularis neurons to peripheral nociceptive stimuli |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T09%3A43%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age-related%20alterations%20in%20responses%20of%20Nucleus%20basalis%20magnocellularis%20neurons%20to%20peripheral%20nociceptive%20stimuli&rft.jtitle=Brain%20research&rft.au=Zhang,%20Yu-Qiu&rft.date=2002-09-06&rft.volume=948&rft.issue=1&rft.spage=47&rft.epage=55&rft.pages=47-55&rft.issn=0006-8993&rft.eissn=1872-6240&rft.coden=BRREAP&rft_id=info:doi/10.1016/S0006-8993(02)02947-5&rft_dat=%3Cproquest_cross%3E72186059%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18607317&rft_id=info:pmid/12383954&rft_els_id=S0006899302029475&rfr_iscdi=true |