Proteomic Method Identifies Proteins Nitrated in vivo during Inflammatory Challenge

Inflammation in asthma, sepsis, transplant rejection, and many neurodegenerative diseases associates an up-regulation of NO synthesis with increased protein nitration at tyrosine. Nitration can cause protein dysfunction and is implicated in pathogenesis, but few proteins that appear nitrated in vivo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-10, Vol.98 (21), p.12056-12061
Hauptverfasser:	Aulak, Kulwant S., Miyagi, Masaru, Yan, Lin, West, Karen A., Massillon, Duna, Crabb, John W., Stuehr, Dennis J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Biological Sciences Cellular biology Cytokines Dehydrogenases Disease Electrophoresis, Gel, Two-Dimensional - methods Enzymes Gels Gene Expression Humans Immunology Interferon-gamma - pharmacology Interleukin-1 - pharmacology Liver Metabolism Nervous system diseases Nitrates - metabolism Nitration Nitric Oxide - metabolism Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II nitrotyrosine Parkinson disease Proteins Proteome - metabolism Proteomics Rats Rats, Sprague-Dawley Tumor Cells, Cultured Tumor Necrosis Factor-alpha - pharmacology tyrosine
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