Pathogenesis and Management of Polyomavirus Infection in Transplant Recipients
Polyomaviruses (JC virus [JCV], BK virus [BKV], and simian virus 40 [SV40]) establish subclinical and persistent infections and share the capacity for reactivation from latency in their host under immunosuppression. JCV establishes latency mainly in the kidney, and its reactivation results in the de...
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| Veröffentlicht in: | Clinical infectious diseases 2002-11, Vol.35 (9), p.1081-1087 |
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| container_title | Clinical infectious diseases |
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| creator | Snydman, David R. Kwak, Eun Jeong Vilchez, Regis A. Randhawa, Parmjeet Shapiro, Ron Butel, Janet S. Kusne, Shimon |
| description | Polyomaviruses (JC virus [JCV], BK virus [BKV], and simian virus 40 [SV40]) establish subclinical and persistent infections and share the capacity for reactivation from latency in their host under immunosuppression. JCV establishes latency mainly in the kidney, and its reactivation results in the development of progressive multifocal leukoencephalopathy. BKV causes infection in the kidney and the urinary tract, and its activation causes a number of disorders, including nephropathy and hemorrhagic cystitis. Recent studies have reported SV40 in the allografts of children who received renal transplants and in the urine, blood, and kidneys of adults with focal segmental glomerulosclerosis, which is a cause of end-stage renal disease and an indication for kidney transplantation. Clinical syndromes related to polyomavirus infection are summarized in the present review, and strategies for the management of patients who receive transplants are discussed. |
| doi_str_mv | 10.1086/344060 |
| format | Article |
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JCV establishes latency mainly in the kidney, and its reactivation results in the development of progressive multifocal leukoencephalopathy. BKV causes infection in the kidney and the urinary tract, and its activation causes a number of disorders, including nephropathy and hemorrhagic cystitis. Recent studies have reported SV40 in the allografts of children who received renal transplants and in the urine, blood, and kidneys of adults with focal segmental glomerulosclerosis, which is a cause of end-stage renal disease and an indication for kidney transplantation. Clinical syndromes related to polyomavirus infection are summarized in the present review, and strategies for the management of patients who receive transplants are discussed.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/344060</identifier><identifier>PMID: 12384842</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Cystitis ; Cystitis - diagnosis ; Cystitis - etiology ; Epidemiology ; Hemorrhage - diagnosis ; Hemorrhage - etiology ; Homologous transplantation ; Humans ; Immunocompromised Host ; Immunocompromised Hosts ; Infections ; JC virus ; Kidneys ; Nephritis - diagnosis ; Nephritis - etiology ; Polyomavirus ; Polyomavirus infections ; Polyomavirus Infections - diagnosis ; Polyomavirus Infections - epidemiology ; Polyomavirus Infections - physiopathology ; Polyomavirus Infections - therapy ; Syndrome ; Transplantation ; Transplants - adverse effects ; Viruses</subject><ispartof>Clinical infectious diseases, 2002-11, Vol.35 (9), p.1081-1087</ispartof><rights>Copyright 2002 The Infectious Diseases Society of America</rights><rights>2002 by the Infectious Diseases Society of America 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-12de1755fa3d66af3db6282954923b0aefa65db3f30fe731d35ff81c30b8b7e03</citedby><cites>FETCH-LOGICAL-c420t-12de1755fa3d66af3db6282954923b0aefa65db3f30fe731d35ff81c30b8b7e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4483268$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4483268$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12384842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Snydman, David R.</creatorcontrib><creatorcontrib>Kwak, Eun Jeong</creatorcontrib><creatorcontrib>Vilchez, Regis A.</creatorcontrib><creatorcontrib>Randhawa, Parmjeet</creatorcontrib><creatorcontrib>Shapiro, Ron</creatorcontrib><creatorcontrib>Butel, Janet S.</creatorcontrib><creatorcontrib>Kusne, Shimon</creatorcontrib><title>Pathogenesis and Management of Polyomavirus Infection in Transplant Recipients</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>Polyomaviruses (JC virus [JCV], BK virus [BKV], and simian virus 40 [SV40]) establish subclinical and persistent infections and share the capacity for reactivation from latency in their host under immunosuppression. JCV establishes latency mainly in the kidney, and its reactivation results in the development of progressive multifocal leukoencephalopathy. BKV causes infection in the kidney and the urinary tract, and its activation causes a number of disorders, including nephropathy and hemorrhagic cystitis. Recent studies have reported SV40 in the allografts of children who received renal transplants and in the urine, blood, and kidneys of adults with focal segmental glomerulosclerosis, which is a cause of end-stage renal disease and an indication for kidney transplantation. Clinical syndromes related to polyomavirus infection are summarized in the present review, and strategies for the management of patients who receive transplants are discussed.</description><subject>Cystitis</subject><subject>Cystitis - diagnosis</subject><subject>Cystitis - etiology</subject><subject>Epidemiology</subject><subject>Hemorrhage - diagnosis</subject><subject>Hemorrhage - etiology</subject><subject>Homologous transplantation</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Immunocompromised Hosts</subject><subject>Infections</subject><subject>JC virus</subject><subject>Kidneys</subject><subject>Nephritis - diagnosis</subject><subject>Nephritis - etiology</subject><subject>Polyomavirus</subject><subject>Polyomavirus infections</subject><subject>Polyomavirus Infections - diagnosis</subject><subject>Polyomavirus Infections - epidemiology</subject><subject>Polyomavirus Infections - physiopathology</subject><subject>Polyomavirus Infections - therapy</subject><subject>Syndrome</subject><subject>Transplantation</subject><subject>Transplants - adverse effects</subject><subject>Viruses</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9P3DAQxa2qCCiln6CqwqW3gP_be6wWCoiFrhBIiIvlJGNquomDnVTst8coKzhVPc1I7zdPM28Q-kLwIcFaHjHOscQf0C4RTJVSzMjH3GOhS66Z3kGfUnrEmBCNxTbaIZRprjndRVdLO_wOD9BB8qmwXVNc2s4-QAvdUARXLMNqHVr718cxFeedg3rwoSt8V9xE26V-ZTN3DbXvfZ5In9GWs6sE-5u6h25_ntzMz8rFr9Pz-Y9FWXOKh5LQBogSwlnWSGkdaypJNZ0JPqOswhaclaKpmGPYgWKkYcI5TWqGK10pwGwPfZ98-xieRkiDaX2qYZXXgTAmoyjJ50n-X5BohYUgs3ewjiGlCM700bc2rg3B5jViM0WcwW8bx7FqoXnHNplm4GACwtj_2-TrxDymIcQ3iudnUamzXE6yTwM8v8k2_jFSMSXM2d29wRf37E4cK7NkL61PmFs</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Snydman, David R.</creator><creator>Kwak, Eun Jeong</creator><creator>Vilchez, Regis A.</creator><creator>Randhawa, Parmjeet</creator><creator>Shapiro, Ron</creator><creator>Butel, Janet S.</creator><creator>Kusne, Shimon</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Pathogenesis and Management of Polyomavirus Infection in Transplant Recipients</title><author>Snydman, David R. ; Kwak, Eun Jeong ; Vilchez, Regis A. ; Randhawa, Parmjeet ; Shapiro, Ron ; Butel, Janet S. ; Kusne, Shimon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-12de1755fa3d66af3db6282954923b0aefa65db3f30fe731d35ff81c30b8b7e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Cystitis</topic><topic>Cystitis - diagnosis</topic><topic>Cystitis - etiology</topic><topic>Epidemiology</topic><topic>Hemorrhage - diagnosis</topic><topic>Hemorrhage - etiology</topic><topic>Homologous transplantation</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Immunocompromised Hosts</topic><topic>Infections</topic><topic>JC virus</topic><topic>Kidneys</topic><topic>Nephritis - diagnosis</topic><topic>Nephritis - etiology</topic><topic>Polyomavirus</topic><topic>Polyomavirus infections</topic><topic>Polyomavirus Infections - diagnosis</topic><topic>Polyomavirus Infections - epidemiology</topic><topic>Polyomavirus Infections - physiopathology</topic><topic>Polyomavirus Infections - therapy</topic><topic>Syndrome</topic><topic>Transplantation</topic><topic>Transplants - adverse effects</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Snydman, David R.</creatorcontrib><creatorcontrib>Kwak, Eun Jeong</creatorcontrib><creatorcontrib>Vilchez, Regis A.</creatorcontrib><creatorcontrib>Randhawa, Parmjeet</creatorcontrib><creatorcontrib>Shapiro, Ron</creatorcontrib><creatorcontrib>Butel, Janet S.</creatorcontrib><creatorcontrib>Kusne, Shimon</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Snydman, David R.</au><au>Kwak, Eun Jeong</au><au>Vilchez, Regis A.</au><au>Randhawa, Parmjeet</au><au>Shapiro, Ron</au><au>Butel, Janet S.</au><au>Kusne, Shimon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathogenesis and Management of Polyomavirus Infection in Transplant Recipients</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>35</volume><issue>9</issue><spage>1081</spage><epage>1087</epage><pages>1081-1087</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Polyomaviruses (JC virus [JCV], BK virus [BKV], and simian virus 40 [SV40]) establish subclinical and persistent infections and share the capacity for reactivation from latency in their host under immunosuppression. 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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Cystitis Cystitis - diagnosis Cystitis - etiology Epidemiology Hemorrhage - diagnosis Hemorrhage - etiology Homologous transplantation Humans Immunocompromised Host Immunocompromised Hosts Infections JC virus Kidneys Nephritis - diagnosis Nephritis - etiology Polyomavirus Polyomavirus infections Polyomavirus Infections - diagnosis Polyomavirus Infections - epidemiology Polyomavirus Infections - physiopathology Polyomavirus Infections - therapy Syndrome Transplantation Transplants - adverse effects Viruses |
| title | Pathogenesis and Management of Polyomavirus Infection in Transplant Recipients |
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