Bilateral segmental neurofibromatosis: a case report and review
A 65‐year‐old white woman presented with complaints of ‘‘moles’' on the left side of her trunk present for an undetermined period of time. She denied associated pain and pruritus. Her past medical history was significant for hypothyroidism and depression, for which she was taking levothyroxine...
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| Veröffentlicht in: | International journal of dermatology 2001-06, Vol.40 (6), p.409-411 |
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| creator | Krishnan, Ravi S. Angel, Tiffany A. Orengo, Ida F. Hsu, Sylvia |
| description | A 65‐year‐old white woman presented with complaints of ‘‘moles’' on the left side of her trunk present for an undetermined period of time. She denied associated pain and pruritus. Her past medical history was significant for hypothyroidism and depression, for which she was taking levothyroxine and venlafaxine, respectively. In addition, she was on hormone replacement therapy. Reportedly, no other family members were affected by similar skin lesions.
Physical examination revealed soft, dome‐shaped, skin‐colored papules grouped in a T11–12 dermatomal distribution on her trunk bilaterally. The lesions were more numerous and densely grouped on the right side of her trunk (Figs 1 and 2). No axillary freckling or café‐au‐lait macules were noted. No Lisch nodules were observed upon ophthalmologic examination.
1
Dermatomal distribution of neurofibromas on the right flank
2
Less obvious dermatomal distribution of neurofibromas on the left abdomen
Histologic examination of skin biopsies taken from lesions on both sides of her abdomen in the affected area revealed a proliferation of fusiform cells in a loose fibrous stroma, consistent with neurofibroma. |
| doi_str_mv | 10.1046/j.1365-4362.2001.01246-4.x |
| format | Article |
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Physical examination revealed soft, dome‐shaped, skin‐colored papules grouped in a T11–12 dermatomal distribution on her trunk bilaterally. The lesions were more numerous and densely grouped on the right side of her trunk (Figs 1 and 2). No axillary freckling or café‐au‐lait macules were noted. No Lisch nodules were observed upon ophthalmologic examination.
1
Dermatomal distribution of neurofibromas on the right flank
2
Less obvious dermatomal distribution of neurofibromas on the left abdomen
Histologic examination of skin biopsies taken from lesions on both sides of her abdomen in the affected area revealed a proliferation of fusiform cells in a loose fibrous stroma, consistent with neurofibroma.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1046/j.1365-4362.2001.01246-4.x</identifier><identifier>PMID: 11589748</identifier><identifier>CODEN: IJDEBB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Aged ; Biological and medical sciences ; Dermatology ; Female ; Humans ; Medical sciences ; Neurofibromatosis 1 - diagnosis ; Neurofibromatosis 1 - pathology ; Neurofibromatosis 1 - surgery ; Prognosis ; Risk Assessment ; Skin - pathology ; Skin Neoplasms - diagnosis ; Skin Neoplasms - pathology ; Skin Neoplasms - surgery ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>International journal of dermatology, 2001-06, Vol.40 (6), p.409-411</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Jun 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4674-752a38b5c44737c6b10101fd23b0d2bb2b8f19af10ed5f6f0253e20d564499e33</citedby><cites>FETCH-LOGICAL-c4674-752a38b5c44737c6b10101fd23b0d2bb2b8f19af10ed5f6f0253e20d564499e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-4362.2001.01246-4.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-4362.2001.01246-4.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,1411,23910,23911,25119,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1138942$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11589748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krishnan, Ravi S.</creatorcontrib><creatorcontrib>Angel, Tiffany A.</creatorcontrib><creatorcontrib>Orengo, Ida F.</creatorcontrib><creatorcontrib>Hsu, Sylvia</creatorcontrib><title>Bilateral segmental neurofibromatosis: a case report and review</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>A 65‐year‐old white woman presented with complaints of ‘‘moles’' on the left side of her trunk present for an undetermined period of time. She denied associated pain and pruritus. Her past medical history was significant for hypothyroidism and depression, for which she was taking levothyroxine and venlafaxine, respectively. In addition, she was on hormone replacement therapy. Reportedly, no other family members were affected by similar skin lesions.
Physical examination revealed soft, dome‐shaped, skin‐colored papules grouped in a T11–12 dermatomal distribution on her trunk bilaterally. The lesions were more numerous and densely grouped on the right side of her trunk (Figs 1 and 2). No axillary freckling or café‐au‐lait macules were noted. No Lisch nodules were observed upon ophthalmologic examination.
1
Dermatomal distribution of neurofibromas on the right flank
2
Less obvious dermatomal distribution of neurofibromas on the left abdomen
Histologic examination of skin biopsies taken from lesions on both sides of her abdomen in the affected area revealed a proliferation of fusiform cells in a loose fibrous stroma, consistent with neurofibroma.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Neurofibromatosis 1 - diagnosis</subject><subject>Neurofibromatosis 1 - pathology</subject><subject>Neurofibromatosis 1 - surgery</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Skin - pathology</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - surgery</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1v1DAQhi0EokvhL6CoQtwS7PFH7F5QKVC6quAC4mg5yQR5ycfWTuj23-OQFSBuyAePNc-8Hj2EnDFaMCrUq13BuJK54AoKoJQVlIFQuSgOD8hmbSkOD8km9VhuqDQn5EmMu_TkwMRjcsKY1KYUekNev_GdmzC4Lov4rcdhStWAcxhbX4Wxd9MYfTzPXFa7iFnA_RimzA1NKn94vHtKHrWui_jseJ-SL-_ffb78kN98urq-vLjJa6FKkZcSHNeVrIUoeVmritF02gZ4RRuoKqh0y4xrGcVGtqqlIDkCbaQSwhjk_JS8XHP3YbydMU6297HGrnMDjnO0JTDNDYUEnv0D7sY5DGk3CwDacKp1gs5XqA5jjAFbuw--d-HeMmoXx3ZnF5F2cWwXx_aXYyvsIQ0_P_4wVz02f0aPUhPw4gi4WLuuDW6offyL49qIZdOLFbvzHd7_xwb2evt2rVNGvmb4OOHhd4YL361KoqX9-vHKCqFgu5WQAn8CipGlZg</recordid><startdate>200106</startdate><enddate>200106</enddate><creator>Krishnan, Ravi S.</creator><creator>Angel, Tiffany A.</creator><creator>Orengo, Ida F.</creator><creator>Hsu, Sylvia</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200106</creationdate><title>Bilateral segmental neurofibromatosis: a case report and review</title><author>Krishnan, Ravi S. ; Angel, Tiffany A. ; Orengo, Ida F. ; Hsu, Sylvia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4674-752a38b5c44737c6b10101fd23b0d2bb2b8f19af10ed5f6f0253e20d564499e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Neurofibromatosis 1 - diagnosis</topic><topic>Neurofibromatosis 1 - pathology</topic><topic>Neurofibromatosis 1 - surgery</topic><topic>Prognosis</topic><topic>Risk Assessment</topic><topic>Skin - pathology</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - surgery</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krishnan, Ravi S.</creatorcontrib><creatorcontrib>Angel, Tiffany A.</creatorcontrib><creatorcontrib>Orengo, Ida F.</creatorcontrib><creatorcontrib>Hsu, Sylvia</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krishnan, Ravi S.</au><au>Angel, Tiffany A.</au><au>Orengo, Ida F.</au><au>Hsu, Sylvia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bilateral segmental neurofibromatosis: a case report and review</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2001-06</date><risdate>2001</risdate><volume>40</volume><issue>6</issue><spage>409</spage><epage>411</epage><pages>409-411</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><coden>IJDEBB</coden><abstract>A 65‐year‐old white woman presented with complaints of ‘‘moles’' on the left side of her trunk present for an undetermined period of time. She denied associated pain and pruritus. Her past medical history was significant for hypothyroidism and depression, for which she was taking levothyroxine and venlafaxine, respectively. In addition, she was on hormone replacement therapy. Reportedly, no other family members were affected by similar skin lesions.
Physical examination revealed soft, dome‐shaped, skin‐colored papules grouped in a T11–12 dermatomal distribution on her trunk bilaterally. The lesions were more numerous and densely grouped on the right side of her trunk (Figs 1 and 2). No axillary freckling or café‐au‐lait macules were noted. No Lisch nodules were observed upon ophthalmologic examination.
1
Dermatomal distribution of neurofibromas on the right flank
2
Less obvious dermatomal distribution of neurofibromas on the left abdomen
Histologic examination of skin biopsies taken from lesions on both sides of her abdomen in the affected area revealed a proliferation of fusiform cells in a loose fibrous stroma, consistent with neurofibroma.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11589748</pmid><doi>10.1046/j.1365-4362.2001.01246-4.x</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Biological and medical sciences Dermatology Female Humans Medical sciences Neurofibromatosis 1 - diagnosis Neurofibromatosis 1 - pathology Neurofibromatosis 1 - surgery Prognosis Risk Assessment Skin - pathology Skin Neoplasms - diagnosis Skin Neoplasms - pathology Skin Neoplasms - surgery Tumors of the skin and soft tissue. Premalignant lesions |
| title | Bilateral segmental neurofibromatosis: a case report and review |
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