Experimental Validation of Monte Carlo Depth-Dose Calculations using Radiochromic Dye Film Dosimetry for a Beta-Gamma 153Sm Radionuclide Applied to the Treatment of Rheumatoid Arthritis
In this work we compare the Monte Carlo (MCNP4B) calculated beta-gamma depth-dose profile for a liquid 153Sm beta-gamma source used in radiation synovectomy with the experimental depth-dose distribution obtained using radiochromic dye film dosimetry. The calculated and experimental depth-dose distri...
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Veröffentlicht in: | Radiation protection dosimetry 2002-08, Vol.101 (1-4), p.439-444 |
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creator | E. Villarreal-Barajas, J. Ferro-Flores, G. Hernandez-Oviedo, O. |
description | In this work we compare the Monte Carlo (MCNP4B) calculated beta-gamma depth-dose profile for a liquid 153Sm beta-gamma source used in radiation synovectomy with the experimental depth-dose distribution obtained using radiochromic dye film dosimetry. The calculated and experimental depth-dose distribution shows a very good agreement (within 5%) in the region where the dose deposition is dominated by the beta particle component (first 800 µm depth on tissue-equivalent material). The agreement worsens, reaching a maximum deviation of 15%, at depths close to the maximum range of the beta particles. Finally the agreement improves for the region where the gamma component accounts for one-third of the total absorbed dose (depths >1 mm ). The possible contributions to these differences are discussed, as well as their relevance for the application of 153Sm in the treatment of rheumatoid arthritis. |
doi_str_mv | 10.1093/oxfordjournals.rpd.a006021 |
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Villarreal-Barajas, J. ; Ferro-Flores, G. ; Hernandez-Oviedo, O.</creator><creatorcontrib>E. Villarreal-Barajas, J. ; Ferro-Flores, G. ; Hernandez-Oviedo, O.</creatorcontrib><description>In this work we compare the Monte Carlo (MCNP4B) calculated beta-gamma depth-dose profile for a liquid 153Sm beta-gamma source used in radiation synovectomy with the experimental depth-dose distribution obtained using radiochromic dye film dosimetry. The calculated and experimental depth-dose distribution shows a very good agreement (within 5%) in the region where the dose deposition is dominated by the beta particle component (first 800 µm depth on tissue-equivalent material). The agreement worsens, reaching a maximum deviation of 15%, at depths close to the maximum range of the beta particles. Finally the agreement improves for the region where the gamma component accounts for one-third of the total absorbed dose (depths >1 mm ). The possible contributions to these differences are discussed, as well as their relevance for the application of 153Sm in the treatment of rheumatoid arthritis.</description><identifier>ISSN: 0144-8420</identifier><identifier>EISSN: 1742-3406</identifier><identifier>DOI: 10.1093/oxfordjournals.rpd.a006021</identifier><identifier>PMID: 12382786</identifier><identifier>CODEN: RPDODE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Arthritis, Rheumatoid - radiotherapy ; Beta Particles ; Biological and medical sciences ; Coloring Agents ; Gamma Rays ; Humans ; Medical sciences ; Monte Carlo Method ; Radioisotopes - therapeutic use ; Radiometry - methods ; Radiotherapy Dosage ; Reproducibility of Results ; Samarium - therapeutic use</subject><ispartof>Radiation protection dosimetry, 2002-08, Vol.101 (1-4), p.439-444</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2306-bf0334857c1d0430f921d321d8cc2c211dc285355f433d5938349c634869481f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13939587$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12382786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>E. Villarreal-Barajas, J.</creatorcontrib><creatorcontrib>Ferro-Flores, G.</creatorcontrib><creatorcontrib>Hernandez-Oviedo, O.</creatorcontrib><title>Experimental Validation of Monte Carlo Depth-Dose Calculations using Radiochromic Dye Film Dosimetry for a Beta-Gamma 153Sm Radionuclide Applied to the Treatment of Rheumatoid Arthritis</title><title>Radiation protection dosimetry</title><addtitle>Radiat Prot Dosimetry</addtitle><description>In this work we compare the Monte Carlo (MCNP4B) calculated beta-gamma depth-dose profile for a liquid 153Sm beta-gamma source used in radiation synovectomy with the experimental depth-dose distribution obtained using radiochromic dye film dosimetry. The calculated and experimental depth-dose distribution shows a very good agreement (within 5%) in the region where the dose deposition is dominated by the beta particle component (first 800 µm depth on tissue-equivalent material). The agreement worsens, reaching a maximum deviation of 15%, at depths close to the maximum range of the beta particles. Finally the agreement improves for the region where the gamma component accounts for one-third of the total absorbed dose (depths >1 mm ). The possible contributions to these differences are discussed, as well as their relevance for the application of 153Sm in the treatment of rheumatoid arthritis.</description><subject>Arthritis, Rheumatoid - radiotherapy</subject><subject>Beta Particles</subject><subject>Biological and medical sciences</subject><subject>Coloring Agents</subject><subject>Gamma Rays</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Monte Carlo Method</subject><subject>Radioisotopes - therapeutic use</subject><subject>Radiometry - methods</subject><subject>Radiotherapy Dosage</subject><subject>Reproducibility of Results</subject><subject>Samarium - therapeutic use</subject><issn>0144-8420</issn><issn>1742-3406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkd1u1DAQhSMEokvhFZCFBHdZ_Js43G13-4NoBSqlQr2xXNshLk4cbEfafTTeDi8bUXFhjWR_Z-Z4TlG8QXCJYEPe-23rg37wUxiki8sw6qWEsIIYPSkWqKa4JBRWT4sFRJSWnGJ4VLyI8QFCXDeMPi-OECYc17xaFL9Pt6MJtjdDkg7cSme1TNYPwLfgyg_JgLUMzoONGVNXbnzcXzg1ub9UBFO0ww9wLbX1qgu-twpsdgacWdeDTOfGKexA9gskODFJluey7yVAjHztD7JhUnmoAatxdNZokDxInQE3wci0t7V3ct2ZqZfJWw1WIXXBJhtfFs_a_H3zaq7Hxbez05v1RXn5-fzjenVZKkxgVd63kBDKWa2QhpTAtsFIk3y4UlhhhLTCnBHGWkqIZg3hhDaqypKqoRy15Lh4d-g7Bv9rMjGJ3kZlnJOD8VMUNUacMMgz-OEAquBjDKYVY16sDDuBoNgHJ_4PTuTgxBxcFr-ep0z3vdGP0jmpDLydARmVdG2Qg7LxkSMNaRivM1ceOBuT2f57l-GnqGpSM3Hx_U5Ud-zk6svtJ7EhfwAqXLiy</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>E. 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Villarreal-Barajas, J. ; Ferro-Flores, G. ; Hernandez-Oviedo, O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2306-bf0334857c1d0430f921d321d8cc2c211dc285355f433d5938349c634869481f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Arthritis, Rheumatoid - radiotherapy</topic><topic>Beta Particles</topic><topic>Biological and medical sciences</topic><topic>Coloring Agents</topic><topic>Gamma Rays</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Monte Carlo Method</topic><topic>Radioisotopes - therapeutic use</topic><topic>Radiometry - methods</topic><topic>Radiotherapy Dosage</topic><topic>Reproducibility of Results</topic><topic>Samarium - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>E. Villarreal-Barajas, J.</creatorcontrib><creatorcontrib>Ferro-Flores, G.</creatorcontrib><creatorcontrib>Hernandez-Oviedo, O.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiation protection dosimetry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>E. Villarreal-Barajas, J.</au><au>Ferro-Flores, G.</au><au>Hernandez-Oviedo, O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental Validation of Monte Carlo Depth-Dose Calculations using Radiochromic Dye Film Dosimetry for a Beta-Gamma 153Sm Radionuclide Applied to the Treatment of Rheumatoid Arthritis</atitle><jtitle>Radiation protection dosimetry</jtitle><addtitle>Radiat Prot Dosimetry</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>101</volume><issue>1-4</issue><spage>439</spage><epage>444</epage><pages>439-444</pages><issn>0144-8420</issn><eissn>1742-3406</eissn><coden>RPDODE</coden><abstract>In this work we compare the Monte Carlo (MCNP4B) calculated beta-gamma depth-dose profile for a liquid 153Sm beta-gamma source used in radiation synovectomy with the experimental depth-dose distribution obtained using radiochromic dye film dosimetry. The calculated and experimental depth-dose distribution shows a very good agreement (within 5%) in the region where the dose deposition is dominated by the beta particle component (first 800 µm depth on tissue-equivalent material). The agreement worsens, reaching a maximum deviation of 15%, at depths close to the maximum range of the beta particles. Finally the agreement improves for the region where the gamma component accounts for one-third of the total absorbed dose (depths >1 mm ). The possible contributions to these differences are discussed, as well as their relevance for the application of 153Sm in the treatment of rheumatoid arthritis.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>12382786</pmid><doi>10.1093/oxfordjournals.rpd.a006021</doi><tpages>6</tpages></addata></record> |
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source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
subjects | Arthritis, Rheumatoid - radiotherapy Beta Particles Biological and medical sciences Coloring Agents Gamma Rays Humans Medical sciences Monte Carlo Method Radioisotopes - therapeutic use Radiometry - methods Radiotherapy Dosage Reproducibility of Results Samarium - therapeutic use |
title | Experimental Validation of Monte Carlo Depth-Dose Calculations using Radiochromic Dye Film Dosimetry for a Beta-Gamma 153Sm Radionuclide Applied to the Treatment of Rheumatoid Arthritis |
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