Experimental Validation of Monte Carlo Depth-Dose Calculations using Radiochromic Dye Film Dosimetry for a Beta-Gamma 153Sm Radionuclide Applied to the Treatment of Rheumatoid Arthritis

In this work we compare the Monte Carlo (MCNP4B) calculated beta-gamma depth-dose profile for a liquid 153Sm beta-gamma source used in radiation synovectomy with the experimental depth-dose distribution obtained using radiochromic dye film dosimetry. The calculated and experimental depth-dose distri...

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Veröffentlicht in:Radiation protection dosimetry 2002-08, Vol.101 (1-4), p.439-444
Hauptverfasser: E. Villarreal-Barajas, J., Ferro-Flores, G., Hernandez-Oviedo, O.
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container_issue 1-4
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container_title Radiation protection dosimetry
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creator E. Villarreal-Barajas, J.
Ferro-Flores, G.
Hernandez-Oviedo, O.
description In this work we compare the Monte Carlo (MCNP4B) calculated beta-gamma depth-dose profile for a liquid 153Sm beta-gamma source used in radiation synovectomy with the experimental depth-dose distribution obtained using radiochromic dye film dosimetry. The calculated and experimental depth-dose distribution shows a very good agreement (within 5%) in the region where the dose deposition is dominated by the beta particle component (first 800 µm depth on tissue-equivalent material). The agreement worsens, reaching a maximum deviation of 15%, at depths close to the maximum range of the beta particles. Finally the agreement improves for the region where the gamma component accounts for one-third of the total absorbed dose (depths >1 mm ). The possible contributions to these differences are discussed, as well as their relevance for the application of 153Sm in the treatment of rheumatoid arthritis.
doi_str_mv 10.1093/oxfordjournals.rpd.a006021
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source MEDLINE; Oxford University Press Journals All Titles (1996-Current)
subjects Arthritis, Rheumatoid - radiotherapy
Beta Particles
Biological and medical sciences
Coloring Agents
Gamma Rays
Humans
Medical sciences
Monte Carlo Method
Radioisotopes - therapeutic use
Radiometry - methods
Radiotherapy Dosage
Reproducibility of Results
Samarium - therapeutic use
title Experimental Validation of Monte Carlo Depth-Dose Calculations using Radiochromic Dye Film Dosimetry for a Beta-Gamma 153Sm Radionuclide Applied to the Treatment of Rheumatoid Arthritis
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