Oxidative brain injury from extravasated erythrocytes after intracerebral hemorrhage

Intracerebral infusion of lysed erythrocytes causes brain edema without inducing ischemic cerebral blood flow. Reports have indicated that oxidative damage contributes to secondary brain injury in stroke. In the present study, we investigated whether erythrocyte lysis after intracerebral hemorrhage...

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Veröffentlicht in:	Brain research 2002-10, Vol.953 (1), p.45-52
Hauptverfasser:	Wu, Jimin, Hua, Ya, Keep, Richard F, Schallert, Timothy, Hoff, Julian T, Xi, Guohua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Edema - metabolism Brain Edema - pathology Cerebral hemorrhage Cerebral Hemorrhage - metabolism Cerebral Hemorrhage - pathology DNA Damage Erythrocyte Erythrocytes - metabolism Heme Oxygenase (Decyclizing) - metabolism Heme Oxygenase-1 Hemolysis In Situ Nick-End Labeling Male Medical sciences Neurological deficit Neurology Oxidation Oxidative Stress - physiology Rats Rats, Sprague-Dawley Superoxide dismutase Superoxide Dismutase - metabolism Vascular diseases and vascular malformations of the nervous system
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