Combined EM/X-Ray Imaging Yields a Quasi-Atomic Model of the Adenovirus-Related Bacteriophage PRD1 and Shows Key Capsid and Membrane Interactions

Background: The dsDNA bacteriophage PRD1 has a membrane inside its icosahedral capsid. While its large size (66 MDa) hinders the study of the complete virion at atomic resolution, a 1.65-Å crystallographic structure of its major coat protein, P3, is available. Cryo-electron microscopy (cryo-EM) and...

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Veröffentlicht in:	Structure (London) 2001-10, Vol.9 (10), p.917-930
Hauptverfasser:	Martı́n, Carmen San, Burnett, Roger M., de Haas, Felix, Heinkel, Ralph, Rutten, Twan, Fuller, Stephen D., Butcher, Sarah J., Bamford, Dennis H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses, Human - chemistry bacteriophage Bacteriophage PRD1 - chemistry Bacteriophage PRD1 - ultrastructure Capsid - chemistry Capsid - ultrastructure Computer Simulation Cryoelectron Microscopy - methods Crystallography, X-Ray - methods DNA, Viral - chemistry DNA, Viral - ultrastructure electron microscopy Image Enhancement - methods Models, Molecular Protein Conformation Tectiviridae Viral Envelope Proteins - chemistry Viral Envelope Proteins - ultrastructure Virion - chemistry Virion - ultrastructure virus structure X-ray crystallography
Online-Zugang:	Volltext
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