Evolutionary HMMs: a Bayesian approach to multiple alignment

Motivation: We review proposed syntheses of probabilistic sequence alignment, profiling and phylogeny. We develop a multiple alignment algorithm for Bayesian inference in the links model proposed by Thorne et al. (1991, J. Mol. Evol. , 33, 114–124). The algorithm, described in detail in Section 3, s...

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Veröffentlicht in:	Bioinformatics 2001-09, Vol.17 (9), p.803-820
Hauptverfasser:	Holmes, Ian, Bruno, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Bayes Theorem Biological and medical sciences Computer Simulation Databases, Protein Evolution, Molecular Fundamental and applied biological sciences. Psychology General aspects Humans Markov Chains Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Models, Statistical Proteins - chemistry Sequence Alignment - methods Sequence Alignment - statistics & numerical data Sequence Analysis, DNA - statistics & numerical data Software
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