Repetitive intrathecal injections of poliovirus replicons result in gene expression in neurons of the central nervous system without pathogenesis

Poliovirus-based vectors (replicons) can be used for gene delivery to motor neurons of the CNS. In the current study, a replicon encoding green fluorescent protein (GFP) was encapsidated into authentic poliovirions, using established procedures. Intrathecal delivery of encapsidated replicons encodin...

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Veröffentlicht in:	Human gene therapy 2001-10, Vol.12 (15), p.1827-1841
Hauptverfasser:	JACKSON, Cheryl A, COBBS, Charles, PEDUZZI, Jean D, NOVAK, Miroslav, MORROW, Casey D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Central Nervous System - metabolism Fundamental and applied biological sciences. Psychology Gene therapy Gene Transfer Techniques Genetic Therapy - methods Green Fluorescent Proteins Health. Pharmaceutical industry HeLa Cells Humans Industrial applications and implications. Economical aspects Injections, Spinal Luminescent Proteins - metabolism Medical sciences Mice Mice, Transgenic Microscopy, Fluorescence Nervous System Diseases - therapy Neurons - metabolism Poliovirus Poliovirus - genetics Spinal Cord - cytology Spinal Cord - pathology Spinal Cord Injuries - therapy Time Factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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