TT virus infection and genotype distribution in blood donors and a group of patients from Turkey
TT virus (TTV) DNA has been found in a large proportion of patients with different forms of non-A-G hepatitis, however the clinical importance is unclear. We aimed to determine the genotypes of TTV isolates found in blood donors and different patient groups from the western part of Turkey. TT DNA wa...
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| Veröffentlicht in: | Infection 2002-10, Vol.30 (5), p.299-302 |
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| creator | ERENSOY, S SAYINER, A. A TÜRKOGLU, S CANATAN, D AKARCA, U. S SERTÖZ, R ÖZACAR, T BATUR, Y BADUR, S BILGIC, A |
| description | TT virus (TTV) DNA has been found in a large proportion of patients with different forms of non-A-G hepatitis, however the clinical importance is unclear. We aimed to determine the genotypes of TTV isolates found in blood donors and different patient groups from the western part of Turkey.
TT DNA was investigated in serum samples of 91 volunteer blood donors (BD), 105 thalassemia (TH) patients, ten patients with fulminant hepatitis (FH) and 16 hemodialysis (HD) patients by heminested PCR using primers NG059, NG061 and NG063 from the ORF1 region. 39 isolates were genotyped by analyzing the partial sequence of ORF1.
TTV DNA was found in 75% of HD, 80% of FH, 61% of TH patients and in 51.6% of BD. Among the sequenced isolates, 14 (35.9%) belonged to genotype 1 (G1) and 25 (64.1%) belonged to genotype 2 (G2). Among the G2 sequences, 22 were grouped as G2c.
TTV infection was common in the population studied, even with moderately sensitive primers. G2 was the major genotype of the studied population without any significant differences in distribution between various patient groups and BD. |
| doi_str_mv | 10.1007/s15010-002-2185-z |
| format | Article |
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TT DNA was investigated in serum samples of 91 volunteer blood donors (BD), 105 thalassemia (TH) patients, ten patients with fulminant hepatitis (FH) and 16 hemodialysis (HD) patients by heminested PCR using primers NG059, NG061 and NG063 from the ORF1 region. 39 isolates were genotyped by analyzing the partial sequence of ORF1.
TTV DNA was found in 75% of HD, 80% of FH, 61% of TH patients and in 51.6% of BD. Among the sequenced isolates, 14 (35.9%) belonged to genotype 1 (G1) and 25 (64.1%) belonged to genotype 2 (G2). Among the G2 sequences, 22 were grouped as G2c.
TTV infection was common in the population studied, even with moderately sensitive primers. G2 was the major genotype of the studied population without any significant differences in distribution between various patient groups and BD.</description><identifier>ISSN: 0300-8126</identifier><identifier>EISSN: 1439-0973</identifier><identifier>DOI: 10.1007/s15010-002-2185-z</identifier><identifier>PMID: 12382090</identifier><identifier>CODEN: IFTNAL</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Blood ; Blood Donors ; Case-Control Studies ; Cohort Studies ; Deoxyribonucleic acid ; DNA ; DNA Virus Infections - blood ; DNA Virus Infections - epidemiology ; DNA Virus Infections - genetics ; DNA, Viral - analysis ; Female ; Genotype ; Genotypes ; Hepatic Encephalopathy - blood ; Hepatitis ; Human viral diseases ; Humans ; Incidence ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Polymerase Chain Reaction - methods ; Reference Values ; Renal Dialysis ; Risk Factors ; Sensitivity and Specificity ; Sequence Analysis, DNA ; Thalassemia - blood ; Torque teno virus - genetics ; Torque teno virus - isolation & purification ; Tropical medicine ; Turkey - epidemiology ; Viral diseases</subject><ispartof>Infection, 2002-10, Vol.30 (5), p.299-302</ispartof><rights>2002 INIST-CNRS</rights><rights>Urban & Vogel Medien und Medizin Verlagsgesellschaft 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-ff5745416615b1ef430dd929dbd26ffd87977446efc8ee594bae314217f514823</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13949789$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12382090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ERENSOY, S</creatorcontrib><creatorcontrib>SAYINER, A. A</creatorcontrib><creatorcontrib>TÜRKOGLU, S</creatorcontrib><creatorcontrib>CANATAN, D</creatorcontrib><creatorcontrib>AKARCA, U. S</creatorcontrib><creatorcontrib>SERTÖZ, R</creatorcontrib><creatorcontrib>ÖZACAR, T</creatorcontrib><creatorcontrib>BATUR, Y</creatorcontrib><creatorcontrib>BADUR, S</creatorcontrib><creatorcontrib>BILGIC, A</creatorcontrib><title>TT virus infection and genotype distribution in blood donors and a group of patients from Turkey</title><title>Infection</title><addtitle>Infection</addtitle><description>TT virus (TTV) DNA has been found in a large proportion of patients with different forms of non-A-G hepatitis, however the clinical importance is unclear. We aimed to determine the genotypes of TTV isolates found in blood donors and different patient groups from the western part of Turkey.
TT DNA was investigated in serum samples of 91 volunteer blood donors (BD), 105 thalassemia (TH) patients, ten patients with fulminant hepatitis (FH) and 16 hemodialysis (HD) patients by heminested PCR using primers NG059, NG061 and NG063 from the ORF1 region. 39 isolates were genotyped by analyzing the partial sequence of ORF1.
TTV DNA was found in 75% of HD, 80% of FH, 61% of TH patients and in 51.6% of BD. Among the sequenced isolates, 14 (35.9%) belonged to genotype 1 (G1) and 25 (64.1%) belonged to genotype 2 (G2). Among the G2 sequences, 22 were grouped as G2c.
TTV infection was common in the population studied, even with moderately sensitive primers. G2 was the major genotype of the studied population without any significant differences in distribution between various patient groups and BD.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood Donors</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Virus Infections - blood</subject><subject>DNA Virus Infections - epidemiology</subject><subject>DNA Virus Infections - genetics</subject><subject>DNA, Viral - analysis</subject><subject>Female</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Hepatic Encephalopathy - blood</subject><subject>Hepatitis</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Reference Values</subject><subject>Renal Dialysis</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Sequence Analysis, DNA</subject><subject>Thalassemia - blood</subject><subject>Torque teno virus - genetics</subject><subject>Torque teno virus - isolation & purification</subject><subject>Tropical medicine</subject><subject>Turkey - epidemiology</subject><subject>Viral diseases</subject><issn>0300-8126</issn><issn>1439-0973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkU1r3DAQhkVpaTZpf0AvRRSam5MZfVjWsYR-QaCX7VmRLSko9UquZAc2vz5OdiHQS09zmOd9YeYh5APCBQKoy4oSEBoA1jDsZPPwimxQcN2AVvw12QAHaDpk7Qk5rfUOAKQW6i05QcY7Bho25Ga7pfexLJXGFPwwx5yoTY7e-pTn_eSpi3UusV-eNzHRfszZUZdTLvWZtPS25GWiOdDJztGnudJQ8o5ul_LH79-RN8GO1b8_zjPy-9vX7dWP5vrX959XX66bgXdybkKQSkiBbYuyRx8EB-c00653rA3BdUorJUTrw9B5v57RW89RMFRBougYPyPnh96p5L-Lr7PZxTr4cbTJ56UatX4IoP0_iJ1SHCRfwU__gHd5KWk9wjCULShgcoXwAA0l11p8MFOJO1v2BsE8STIHSWaVZJ4kmYc18_FYvPQ7714SRysr8PkI2DrYMRSbhlhfOK6FVp3mj5y7mXE</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>ERENSOY, S</creator><creator>SAYINER, A. 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A</au><au>TÜRKOGLU, S</au><au>CANATAN, D</au><au>AKARCA, U. S</au><au>SERTÖZ, R</au><au>ÖZACAR, T</au><au>BATUR, Y</au><au>BADUR, S</au><au>BILGIC, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TT virus infection and genotype distribution in blood donors and a group of patients from Turkey</atitle><jtitle>Infection</jtitle><addtitle>Infection</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>30</volume><issue>5</issue><spage>299</spage><epage>302</epage><pages>299-302</pages><issn>0300-8126</issn><eissn>1439-0973</eissn><coden>IFTNAL</coden><abstract>TT virus (TTV) DNA has been found in a large proportion of patients with different forms of non-A-G hepatitis, however the clinical importance is unclear. We aimed to determine the genotypes of TTV isolates found in blood donors and different patient groups from the western part of Turkey.
TT DNA was investigated in serum samples of 91 volunteer blood donors (BD), 105 thalassemia (TH) patients, ten patients with fulminant hepatitis (FH) and 16 hemodialysis (HD) patients by heminested PCR using primers NG059, NG061 and NG063 from the ORF1 region. 39 isolates were genotyped by analyzing the partial sequence of ORF1.
TTV DNA was found in 75% of HD, 80% of FH, 61% of TH patients and in 51.6% of BD. Among the sequenced isolates, 14 (35.9%) belonged to genotype 1 (G1) and 25 (64.1%) belonged to genotype 2 (G2). Among the G2 sequences, 22 were grouped as G2c.
TTV infection was common in the population studied, even with moderately sensitive primers. G2 was the major genotype of the studied population without any significant differences in distribution between various patient groups and BD.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>12382090</pmid><doi>10.1007/s15010-002-2185-z</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Blood Blood Donors Case-Control Studies Cohort Studies Deoxyribonucleic acid DNA DNA Virus Infections - blood DNA Virus Infections - epidemiology DNA Virus Infections - genetics DNA, Viral - analysis Female Genotype Genotypes Hepatic Encephalopathy - blood Hepatitis Human viral diseases Humans Incidence Infectious diseases Male Medical sciences Middle Aged Miscellaneous Polymerase Chain Reaction - methods Reference Values Renal Dialysis Risk Factors Sensitivity and Specificity Sequence Analysis, DNA Thalassemia - blood Torque teno virus - genetics Torque teno virus - isolation & purification Tropical medicine Turkey - epidemiology Viral diseases |
| title | TT virus infection and genotype distribution in blood donors and a group of patients from Turkey |
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