Sumoylation of Topoisomerase I Is Involved in Its Partitioning between Nucleoli and Nucleoplasm and Its Clearing from Nucleoli in Response to Camptothecin

Previous studies identified a small fraction of putatively sumoylated topoisomerase I (TOP1) under basal conditions (â¼1%), and anticancer camptothecins that trap the TOP1-DNA covalent intermediate markedly increase the sumoylation of TOP1 (â¤10%). To study the role of the sumoylation of TOP1, we...

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Veröffentlicht in:	The Journal of biological chemistry 2002-10, Vol.277 (42), p.40020-40026
Hauptverfasser:	Rallabhandi, Prasad, Hashimoto, Keiko, Mo, Yin-Yuan, Beck, William T, Moitra, Prasun K, D'Arpa, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antineoplastic Agents, Phytogenic - pharmacology Arginine - chemistry Binding Sites Camptothecin - pharmacology Cell Line Cell Nucleolus - enzymology Cell Nucleus - enzymology Cell Nucleus - metabolism CHO Cells Cricetinae Cytoplasm - enzymology DNA Topoisomerases, Type I - chemistry DNA Topoisomerases, Type I - metabolism Green Fluorescent Proteins HeLa Cells Humans Luminescent Proteins - metabolism Lysine - chemistry Molecular Sequence Data Mutation Plasmids - metabolism Protein Binding Protein Structure, Tertiary Transfection
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