Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein

The microtubule-associated protein tau is a family of six isoforms that becomes abnormally hyperphosphorylated and accumulates in neurons undergoing neurodegeneration in the brains of patients with Alzheimer disease (AD). We investigated the isoform-specific interaction of normal tau with AD hyperph...

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Veröffentlicht in:	The Journal of biological chemistry 2001-10, Vol.276 (41), p.37967-37973
Hauptverfasser:	Alonso, A D, Zaidi, T, Novak, M, Barra, H S, Grundke-Iqbal, I, Iqbal, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Blotting, Western Humans In Vitro Techniques Phosphorylation Protein Binding Protein Isoforms - metabolism Recombinant Proteins - metabolism tau Proteins - metabolism
Online-Zugang:	Volltext
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