Nitric Oxide Is Generated in Smooth Muscle Layer by Neurokinin A and Counteracts Constriction in Guinea Pig Airway

It has been reported that several bronchoconstrictors generate nitric oxide (NO), counteracting bronchoconstriction, and removal of bronchial epithelia reduces NO production. However, it has not been elucidated whether neurokinin A (NKA), a potent bronchoconstrictor liberated from nerve terminals, g...

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Veröffentlicht in:	Nitric oxide 2001-10, Vol.5 (5), p.465-474
Hauptverfasser:	Imasaki, Takao, Kobayashi, Hirosuke, Hataishi, Ryuji, Hayashi, Izumi, Tomita, Tomoyuki, Majima, Masataka
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway Resistance - drug effects Animals asthma Benzamides - pharmacology bronchial smooth muscle Bronchoconstriction - drug effects capsaicin Capsaicin - pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Epithelial Cells - physiology Guanidines - pharmacology Guinea Pigs In Vitro Techniques Male Muscle, Smooth - drug effects Muscle, Smooth - metabolism Neurokinin A - pharmacology NG-Nitroarginine Methyl Ester - pharmacology Nitrates - metabolism nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type I Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Nitrites - metabolism Piperidines - pharmacology Receptors, Neurokinin-2 - agonists Receptors, Neurokinin-2 - antagonists & inhibitors tachykinin Trachea - physiology
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