Metabolic and Skeletal Effects of Low and High Doses of Calcium Acetate in Patients with Preterminal Chronic Renal Failure
Background: Secondary hyperparathyroidism commonly evolves, as the glomerular filtration rate falls. The metabolic and skeletal effects of a possible remedy, calcium acetate, have not been studied in patients with preterminal chronic renal failure. Methods: Men with a mean creatinine clearance of ap...
Gespeichert in:
Veröffentlicht in: | American journal of nephrology 2002-09, Vol.22 (5-6), p.445-454 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 454 |
---|---|
container_issue | 5-6 |
container_start_page | 445 |
container_title | American journal of nephrology |
container_volume | 22 |
creator | Phelps, Kenneth R. Stern, Marc Slingerland, Alice Heravi, Mahin Strogatz, David S. Haqqie, Syed S. |
description | Background: Secondary hyperparathyroidism commonly evolves, as the glomerular filtration rate falls. The metabolic and skeletal effects of a possible remedy, calcium acetate, have not been studied in patients with preterminal chronic renal failure. Methods: Men with a mean creatinine clearance of approximately 30 ml/min took calcium acetate for 24 weeks at doses which provided 507 or 1,521 mg calcium/day with meals. Metabolic determinations were made at intervals of 4–8 weeks, and the bone mineral density (BMD) was measured at the beginning and at the end of the trial. Results: The low-dose regimen produced no metabolic or skeletal effect. In subjects prescribed the high-dose regimen, the 24-hour urine phosphorus excretion fell from 0.53 mg/mg creatinine to values ranging from 0.34 to 0.41 mg/mg creatinine. The theoretical phosphorus threshold concentration rose by a maximum of 38.6%, and the serum phosphorus concentration did not change. The mean serum calcium concentration rose by a maximum of 7.2%. The mean fractional changes in parathyroid hormone and 1,25-dihydroxyvitamin D concentrations ranged from –27.0 to –39.6% and from –5.0 to –20.3%, respectively. The BMD increased at L1, L3, and L4. Conclusion: Calcium acetate prescribed to deliver 1,521 mg calcium/day with meals reduced parathyroid hormone and 1,25-dihydroxyvitamin D concentrations and increased lumbar BMD in men with preterminal chronic renal failure. |
doi_str_mv | 10.1159/000065273 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72178270</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>21258827</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-3681859a37fd8060168a761da478265d2bf55e3cb4c784120063a07762bfb6293</originalsourceid><addsrcrecordid>eNqFkc9LHDEcxYNYdLv14FmQUGihh2mTzOTXUbZaC1sqbT0Pmcx33GhmYpMZpP3rm3UWhV7MJeT7_eQ9eA-hY0o-Usr1J5KP4EyWe2hBK0YLLSTZRwvCOCkU0fwQvU7plhDKFJEH6JCyUlFdsQX6-w1G0wTvLDZDi3_egc8Dj8-7DuyYcOjwOjw87i7dzQZ_DgkepyvjrZt6fGYzPwJ2A74yo4Mhf3pw4wZfRRgh9m7IaqtNDEO2-AHb14VxforwBr3qjE9wtLuX6Pri_Nfqslh___J1dbYubMXIWJRCUcW1KWXXKiIIFcpIQVtTScUEb1nTcQ6lbSorVUVZjqI0REqRF41gulyi97PufQy_J0hj3btkwXszQJhSLRnNSpK8CDLKuMrkyyBRWs_Wb_8Db8MUcwaZYbkNrflW7cMM2RhSitDV99H1Jv6pKam3_dZP_Wb2dCc4NT20z-Su0Ay82wEmWeO7aAbr0jNXaq5kTmiJTmbuzsQbiE_AbPMPG6SyXA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220129957</pqid></control><display><type>article</type><title>Metabolic and Skeletal Effects of Low and High Doses of Calcium Acetate in Patients with Preterminal Chronic Renal Failure</title><source>MEDLINE</source><source>Karger Journals</source><creator>Phelps, Kenneth R. ; Stern, Marc ; Slingerland, Alice ; Heravi, Mahin ; Strogatz, David S. ; Haqqie, Syed S.</creator><creatorcontrib>Phelps, Kenneth R. ; Stern, Marc ; Slingerland, Alice ; Heravi, Mahin ; Strogatz, David S. ; Haqqie, Syed S.</creatorcontrib><description>Background: Secondary hyperparathyroidism commonly evolves, as the glomerular filtration rate falls. The metabolic and skeletal effects of a possible remedy, calcium acetate, have not been studied in patients with preterminal chronic renal failure. Methods: Men with a mean creatinine clearance of approximately 30 ml/min took calcium acetate for 24 weeks at doses which provided 507 or 1,521 mg calcium/day with meals. Metabolic determinations were made at intervals of 4–8 weeks, and the bone mineral density (BMD) was measured at the beginning and at the end of the trial. Results: The low-dose regimen produced no metabolic or skeletal effect. In subjects prescribed the high-dose regimen, the 24-hour urine phosphorus excretion fell from 0.53 mg/mg creatinine to values ranging from 0.34 to 0.41 mg/mg creatinine. The theoretical phosphorus threshold concentration rose by a maximum of 38.6%, and the serum phosphorus concentration did not change. The mean serum calcium concentration rose by a maximum of 7.2%. The mean fractional changes in parathyroid hormone and 1,25-dihydroxyvitamin D concentrations ranged from –27.0 to –39.6% and from –5.0 to –20.3%, respectively. The BMD increased at L1, L3, and L4. Conclusion: Calcium acetate prescribed to deliver 1,521 mg calcium/day with meals reduced parathyroid hormone and 1,25-dihydroxyvitamin D concentrations and increased lumbar BMD in men with preterminal chronic renal failure.</description><identifier>ISSN: 0250-8095</identifier><identifier>EISSN: 1421-9670</identifier><identifier>DOI: 10.1159/000065273</identifier><identifier>PMID: 12381942</identifier><identifier>CODEN: AJNED9</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Acetates - administration & dosage ; Aged ; Biological and medical sciences ; Bone Density - drug effects ; Calcitriol - blood ; Calcium - blood ; Calcium Compounds ; Clinical Study ; Humans ; Kidney Failure, Chronic - metabolism ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Parathyroid Hormone - blood ; Phosphorus - blood ; Phosphorus - urine ; Prospective Studies ; Renal failure</subject><ispartof>American journal of nephrology, 2002-09, Vol.22 (5-6), p.445-454</ispartof><rights>2002 S. Karger AG, Basel</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 S. Karger AG, Basel</rights><rights>Copyright S. Karger AG Sep-Dec 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-3681859a37fd8060168a761da478265d2bf55e3cb4c784120063a07762bfb6293</citedby><cites>FETCH-LOGICAL-c420t-3681859a37fd8060168a761da478265d2bf55e3cb4c784120063a07762bfb6293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13958706$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12381942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Phelps, Kenneth R.</creatorcontrib><creatorcontrib>Stern, Marc</creatorcontrib><creatorcontrib>Slingerland, Alice</creatorcontrib><creatorcontrib>Heravi, Mahin</creatorcontrib><creatorcontrib>Strogatz, David S.</creatorcontrib><creatorcontrib>Haqqie, Syed S.</creatorcontrib><title>Metabolic and Skeletal Effects of Low and High Doses of Calcium Acetate in Patients with Preterminal Chronic Renal Failure</title><title>American journal of nephrology</title><addtitle>Am J Nephrol</addtitle><description>Background: Secondary hyperparathyroidism commonly evolves, as the glomerular filtration rate falls. The metabolic and skeletal effects of a possible remedy, calcium acetate, have not been studied in patients with preterminal chronic renal failure. Methods: Men with a mean creatinine clearance of approximately 30 ml/min took calcium acetate for 24 weeks at doses which provided 507 or 1,521 mg calcium/day with meals. Metabolic determinations were made at intervals of 4–8 weeks, and the bone mineral density (BMD) was measured at the beginning and at the end of the trial. Results: The low-dose regimen produced no metabolic or skeletal effect. In subjects prescribed the high-dose regimen, the 24-hour urine phosphorus excretion fell from 0.53 mg/mg creatinine to values ranging from 0.34 to 0.41 mg/mg creatinine. The theoretical phosphorus threshold concentration rose by a maximum of 38.6%, and the serum phosphorus concentration did not change. The mean serum calcium concentration rose by a maximum of 7.2%. The mean fractional changes in parathyroid hormone and 1,25-dihydroxyvitamin D concentrations ranged from –27.0 to –39.6% and from –5.0 to –20.3%, respectively. The BMD increased at L1, L3, and L4. Conclusion: Calcium acetate prescribed to deliver 1,521 mg calcium/day with meals reduced parathyroid hormone and 1,25-dihydroxyvitamin D concentrations and increased lumbar BMD in men with preterminal chronic renal failure.</description><subject>Acetates - administration & dosage</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Bone Density - drug effects</subject><subject>Calcitriol - blood</subject><subject>Calcium - blood</subject><subject>Calcium Compounds</subject><subject>Clinical Study</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Parathyroid Hormone - blood</subject><subject>Phosphorus - blood</subject><subject>Phosphorus - urine</subject><subject>Prospective Studies</subject><subject>Renal failure</subject><issn>0250-8095</issn><issn>1421-9670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc9LHDEcxYNYdLv14FmQUGihh2mTzOTXUbZaC1sqbT0Pmcx33GhmYpMZpP3rm3UWhV7MJeT7_eQ9eA-hY0o-Usr1J5KP4EyWe2hBK0YLLSTZRwvCOCkU0fwQvU7plhDKFJEH6JCyUlFdsQX6-w1G0wTvLDZDi3_egc8Dj8-7DuyYcOjwOjw87i7dzQZ_DgkepyvjrZt6fGYzPwJ2A74yo4Mhf3pw4wZfRRgh9m7IaqtNDEO2-AHb14VxforwBr3qjE9wtLuX6Pri_Nfqslh___J1dbYubMXIWJRCUcW1KWXXKiIIFcpIQVtTScUEb1nTcQ6lbSorVUVZjqI0REqRF41gulyi97PufQy_J0hj3btkwXszQJhSLRnNSpK8CDLKuMrkyyBRWs_Wb_8Db8MUcwaZYbkNrflW7cMM2RhSitDV99H1Jv6pKam3_dZP_Wb2dCc4NT20z-Su0Ay82wEmWeO7aAbr0jNXaq5kTmiJTmbuzsQbiE_AbPMPG6SyXA</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>Phelps, Kenneth R.</creator><creator>Stern, Marc</creator><creator>Slingerland, Alice</creator><creator>Heravi, Mahin</creator><creator>Strogatz, David S.</creator><creator>Haqqie, Syed S.</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20020901</creationdate><title>Metabolic and Skeletal Effects of Low and High Doses of Calcium Acetate in Patients with Preterminal Chronic Renal Failure</title><author>Phelps, Kenneth R. ; Stern, Marc ; Slingerland, Alice ; Heravi, Mahin ; Strogatz, David S. ; Haqqie, Syed S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-3681859a37fd8060168a761da478265d2bf55e3cb4c784120063a07762bfb6293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acetates - administration & dosage</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Bone Density - drug effects</topic><topic>Calcitriol - blood</topic><topic>Calcium - blood</topic><topic>Calcium Compounds</topic><topic>Clinical Study</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Parathyroid Hormone - blood</topic><topic>Phosphorus - blood</topic><topic>Phosphorus - urine</topic><topic>Prospective Studies</topic><topic>Renal failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Phelps, Kenneth R.</creatorcontrib><creatorcontrib>Stern, Marc</creatorcontrib><creatorcontrib>Slingerland, Alice</creatorcontrib><creatorcontrib>Heravi, Mahin</creatorcontrib><creatorcontrib>Strogatz, David S.</creatorcontrib><creatorcontrib>Haqqie, Syed S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Phelps, Kenneth R.</au><au>Stern, Marc</au><au>Slingerland, Alice</au><au>Heravi, Mahin</au><au>Strogatz, David S.</au><au>Haqqie, Syed S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic and Skeletal Effects of Low and High Doses of Calcium Acetate in Patients with Preterminal Chronic Renal Failure</atitle><jtitle>American journal of nephrology</jtitle><addtitle>Am J Nephrol</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>22</volume><issue>5-6</issue><spage>445</spage><epage>454</epage><pages>445-454</pages><issn>0250-8095</issn><eissn>1421-9670</eissn><coden>AJNED9</coden><abstract>Background: Secondary hyperparathyroidism commonly evolves, as the glomerular filtration rate falls. The metabolic and skeletal effects of a possible remedy, calcium acetate, have not been studied in patients with preterminal chronic renal failure. Methods: Men with a mean creatinine clearance of approximately 30 ml/min took calcium acetate for 24 weeks at doses which provided 507 or 1,521 mg calcium/day with meals. Metabolic determinations were made at intervals of 4–8 weeks, and the bone mineral density (BMD) was measured at the beginning and at the end of the trial. Results: The low-dose regimen produced no metabolic or skeletal effect. In subjects prescribed the high-dose regimen, the 24-hour urine phosphorus excretion fell from 0.53 mg/mg creatinine to values ranging from 0.34 to 0.41 mg/mg creatinine. The theoretical phosphorus threshold concentration rose by a maximum of 38.6%, and the serum phosphorus concentration did not change. The mean serum calcium concentration rose by a maximum of 7.2%. The mean fractional changes in parathyroid hormone and 1,25-dihydroxyvitamin D concentrations ranged from –27.0 to –39.6% and from –5.0 to –20.3%, respectively. The BMD increased at L1, L3, and L4. Conclusion: Calcium acetate prescribed to deliver 1,521 mg calcium/day with meals reduced parathyroid hormone and 1,25-dihydroxyvitamin D concentrations and increased lumbar BMD in men with preterminal chronic renal failure.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>12381942</pmid><doi>10.1159/000065273</doi><tpages>10</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0250-8095 |
ispartof | American journal of nephrology, 2002-09, Vol.22 (5-6), p.445-454 |
issn | 0250-8095 1421-9670 |
language | eng |
recordid | cdi_proquest_miscellaneous_72178270 |
source | MEDLINE; Karger Journals |
subjects | Acetates - administration & dosage Aged Biological and medical sciences Bone Density - drug effects Calcitriol - blood Calcium - blood Calcium Compounds Clinical Study Humans Kidney Failure, Chronic - metabolism Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Parathyroid Hormone - blood Phosphorus - blood Phosphorus - urine Prospective Studies Renal failure |
title | Metabolic and Skeletal Effects of Low and High Doses of Calcium Acetate in Patients with Preterminal Chronic Renal Failure |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T16%3A07%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metabolic%20and%20Skeletal%20Effects%20of%20Low%20and%20High%20Doses%20of%20Calcium%20Acetate%20in%20Patients%20with%20Preterminal%20Chronic%20Renal%20Failure&rft.jtitle=American%20journal%20of%20nephrology&rft.au=Phelps,%20Kenneth%20R.&rft.date=2002-09-01&rft.volume=22&rft.issue=5-6&rft.spage=445&rft.epage=454&rft.pages=445-454&rft.issn=0250-8095&rft.eissn=1421-9670&rft.coden=AJNED9&rft_id=info:doi/10.1159/000065273&rft_dat=%3Cproquest_cross%3E21258827%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=220129957&rft_id=info:pmid/12381942&rfr_iscdi=true |