The dual role of CTLA-4 in Leishmania infection
The role of CTLA-4 in inducing the production of transforming growth factor β (TGF-β) from T cells during a Leishmania infection has only recently been recognized. However, CTLA-4 and TGF-β affect T helper cells differently, depending on the maturation. This review discusses the data obtained from d...
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| Veröffentlicht in: | Trends in Parasitology 2001-10, Vol.17 (10), p.487-491 |
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| container_title | Trends in Parasitology |
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| creator | Gomes, Nitza A DosReis, George A |
| description | The role of CTLA-4 in inducing the production of transforming growth factor β (TGF-β) from T cells during a
Leishmania infection has only recently been recognized. However, CTLA-4 and TGF-β affect T helper cells differently, depending on the maturation. This review discusses the data obtained from different experimental models and demonstrates that CTLA-4 is a target molecule for vaccination and therapy against leishmaniasis. |
| doi_str_mv | 10.1016/S1471-4922(01)02038-4 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Trends in Parasitology, 2001-10, Vol.17 (10), p.487-491 |
| issn | 1471-4922 1471-5007 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Abatacept Animals Antigens, CD Antigens, Differentiation - physiology Biological and medical sciences CD4 + T cells co-stimulation CTLA-4 CTLA-4 Antigen Experimental protozoal diseases and models Fundamental and applied biological sciences. Psychology Fundamental immunology Humans IFN-γ Immunobiology Immunoconjugates immunosuppression Infectious diseases Leishmania Leishmania - pathogenicity Leishmania - physiology Leishmaniasis - immunology Leishmaniasis - physiopathology macrophages Medical sciences Mice Mice, Inbred BALB C Modulation of the immune response (stimulation, suppression) Parasitic diseases Protozoal diseases T helper lymphocytes T-Lymphocytes, Helper-Inducer - immunology TGF-β Transforming Growth Factor beta - metabolism visceral leishmaniaisis |
| title | The dual role of CTLA-4 in Leishmania infection |
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