Inhibitory effects of tributyltin on dopamine biosynthesis in rat PC12 cells

The inhibitory effects of tributyltin chloride (TBTC) on dopamine biosynthesis in PC12 cells were investigated. Twenty-four hour exposure to TBTC at 0.5 μM showed 32.9% inhibition of dopamine content: the IC 50 value of TBTC was 0.72 μM. Dopamine content decreased at 6 h and reached a minimal level...

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Veröffentlicht in:	Neuroscience letters 2002-10, Vol.332 (1), p.13-16
Hauptverfasser:	Kim, Yu Mi, Lee, Jae Joon, Yin, Shou Yu, Kim, Youngsoo, Lee, Jong Kil, Yoon, Yeo Pyo, Kang, Min Hee, Lee, Myung Koo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Dopamine - biosynthesis Dopamine Antagonists - pharmacology Dose-Response Relationship, Drug Medical sciences Metals and various inorganic compounds PC12 Cells Rats RNA, Messenger - antagonists & inhibitors RNA, Messenger - biosynthesis Toxicology Trialkyltin Compounds - pharmacology Tributyltin Tyrosine 3-Monooxygenase - antagonists & inhibitors Tyrosine 3-Monooxygenase - biosynthesis Tyrosine hydroxylase Tyrosine hydroxylase mRNA
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