Perinatal factors affecting survival and survival without disability of extreme premature infants at two years of age
Objective: To study obstetrical factors leading to very preterm delivery (between 24 and 28 weeks) and to relate these factors to neonatal outcome and psychomotor development at two years. Study design: Among 144 infants born alive before 28 weeks of gestation at a single perinatal center between Ja...
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| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 2002-11, Vol.105 (2), p.124-131 |
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| container_title | European journal of obstetrics & gynecology and reproductive biology |
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| creator | Ayoubi, J.M Audibert, F Boithias, C Zupan, V Taylor, S Bosson, J.L Frydman, R |
| description | Objective: To study obstetrical factors leading to very preterm delivery (between 24 and 28 weeks) and to relate these factors to neonatal outcome and psychomotor development at two years.
Study design: Among 144 infants born alive before 28 weeks of gestation at a single perinatal center between January 1993 and December 1996, we analyzed the influence on neonatal outcome and on psychomotor development at 24 months of a variety of perinatal and neonatal factors. Psychomotor development at two years was classified as: normal, borderline, or moderately or severely handicapped.
Results: During the study period, 114 women delivered live infants before 28 weeks’ gestation: 87 singletons, 25 sets of twins, 1 set of triplets and 1 set of quadruplets. All 144 live-born infants received neonatal resuscitation: 50 died before discharge. At two years of age, 6 of the 94 survivors were lost to follow-up. Assessments of the psychomotor development of the other 88 was normal for 52%; borderline for 20%, moderately handicapped for 20%, and severely handicapped for 8%. Multivariate analysis found that two factors affected survival: birthweight and fetal heart rate. (The 42% of infants with a birthweight below 700
g survived versus 83% above 900
g,
P |
| doi_str_mv | 10.1016/S0301-2115(02)00158-6 |
| format | Article |
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Study design: Among 144 infants born alive before 28 weeks of gestation at a single perinatal center between January 1993 and December 1996, we analyzed the influence on neonatal outcome and on psychomotor development at 24 months of a variety of perinatal and neonatal factors. Psychomotor development at two years was classified as: normal, borderline, or moderately or severely handicapped.
Results: During the study period, 114 women delivered live infants before 28 weeks’ gestation: 87 singletons, 25 sets of twins, 1 set of triplets and 1 set of quadruplets. All 144 live-born infants received neonatal resuscitation: 50 died before discharge. At two years of age, 6 of the 94 survivors were lost to follow-up. Assessments of the psychomotor development of the other 88 was normal for 52%; borderline for 20%, moderately handicapped for 20%, and severely handicapped for 8%. Multivariate analysis found that two factors affected survival: birthweight and fetal heart rate. (The 42% of infants with a birthweight below 700
g survived versus 83% above 900
g,
P<0.001, OR=5.2, 95% CI (confidence interval) [2.4–11.2].)
Conclusion: These data show the influence of perinatal factors on the outcome of very preterm infants; birthweight and fetal heart rate are strongly correlated with survival. Gestational age is a good predictor of psychomotor development at two years.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/S0301-2115(02)00158-6</identifier><identifier>PMID: 12381473</identifier><identifier>CODEN: EOGRAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Birth Weight ; Delivery. Postpartum. Lactation ; Disabled Children - statistics & numerical data ; Disorders ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Heart Rate, Fetal ; Humans ; Infant, Newborn ; Infant, Premature ; Medical sciences ; Perinatal mortality ; Prematurity ; Psychomotor development ; Psychomotor Disorders - epidemiology ; Psychomotor Disorders - mortality ; Survival Rate</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 2002-11, Vol.105 (2), p.124-131</ispartof><rights>2002</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-c0061d7be28ccd0fc9e9869188dd2d7ce27b52a7f1c33d91af0a9717fe5892033</citedby><cites>FETCH-LOGICAL-c391t-c0061d7be28ccd0fc9e9869188dd2d7ce27b52a7f1c33d91af0a9717fe5892033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0301-2115(02)00158-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13979609$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12381473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ayoubi, J.M</creatorcontrib><creatorcontrib>Audibert, F</creatorcontrib><creatorcontrib>Boithias, C</creatorcontrib><creatorcontrib>Zupan, V</creatorcontrib><creatorcontrib>Taylor, S</creatorcontrib><creatorcontrib>Bosson, J.L</creatorcontrib><creatorcontrib>Frydman, R</creatorcontrib><title>Perinatal factors affecting survival and survival without disability of extreme premature infants at two years of age</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>Objective: To study obstetrical factors leading to very preterm delivery (between 24 and 28 weeks) and to relate these factors to neonatal outcome and psychomotor development at two years.
Study design: Among 144 infants born alive before 28 weeks of gestation at a single perinatal center between January 1993 and December 1996, we analyzed the influence on neonatal outcome and on psychomotor development at 24 months of a variety of perinatal and neonatal factors. Psychomotor development at two years was classified as: normal, borderline, or moderately or severely handicapped.
Results: During the study period, 114 women delivered live infants before 28 weeks’ gestation: 87 singletons, 25 sets of twins, 1 set of triplets and 1 set of quadruplets. All 144 live-born infants received neonatal resuscitation: 50 died before discharge. At two years of age, 6 of the 94 survivors were lost to follow-up. Assessments of the psychomotor development of the other 88 was normal for 52%; borderline for 20%, moderately handicapped for 20%, and severely handicapped for 8%. Multivariate analysis found that two factors affected survival: birthweight and fetal heart rate. (The 42% of infants with a birthweight below 700
g survived versus 83% above 900
g,
P<0.001, OR=5.2, 95% CI (confidence interval) [2.4–11.2].)
Conclusion: These data show the influence of perinatal factors on the outcome of very preterm infants; birthweight and fetal heart rate are strongly correlated with survival. Gestational age is a good predictor of psychomotor development at two years.</description><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Disabled Children - statistics & numerical data</subject><subject>Disorders</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Heart Rate, Fetal</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Medical sciences</subject><subject>Perinatal mortality</subject><subject>Prematurity</subject><subject>Psychomotor development</subject><subject>Psychomotor Disorders - epidemiology</subject><subject>Psychomotor Disorders - mortality</subject><subject>Survival Rate</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvFCEUx4mxsWvrR9Bw0djDKA86w3AyptG2SRNNrGfyFh4VMzuzArN1v720u3GP5QAh_N7_wQ_GXoP4AAK6jz-EEtBIgPa9kGdCQNs33TO2gF7LRnft-XO2-I8cs5c5_xZ1KGVesGOQqodzrRZs_k4pjlhw4AFdmVLmGAK5Esc7nue0iZt6hKM_bO5j-TXNhfuYcRmHWLZ8Cpz-lkQr4us6Y5kT8TgGHEvNK7zcT3xLWMMriXd0yo4CDple7dcT9vPrl9uLq-bm2-X1xeebxikDpXFCdOD1kmTvnBfBGTJ9Z6DvvZdeO5J62UrUAZxS3gAGgUaDDtT2Rta3nrB3u9x1mv7MlItdxexoGHCkac5WS9CtAV3Bdge6NOWcKNh1iitMWwvCPvi2j77tg0wrpH30bbta92bfYF6uyB-q9oIr8HYPYHY4hISji_nAKaNNJ0zlPu04qjo2kZLNLtLoyMdUf8P6KT5xlX-SXZ7G</recordid><startdate>20021115</startdate><enddate>20021115</enddate><creator>Ayoubi, J.M</creator><creator>Audibert, F</creator><creator>Boithias, C</creator><creator>Zupan, V</creator><creator>Taylor, S</creator><creator>Bosson, J.L</creator><creator>Frydman, R</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021115</creationdate><title>Perinatal factors affecting survival and survival without disability of extreme premature infants at two years of age</title><author>Ayoubi, J.M ; Audibert, F ; Boithias, C ; Zupan, V ; Taylor, S ; Bosson, J.L ; Frydman, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-c0061d7be28ccd0fc9e9869188dd2d7ce27b52a7f1c33d91af0a9717fe5892033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Disabled Children - statistics & numerical data</topic><topic>Disorders</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Heart Rate, Fetal</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Medical sciences</topic><topic>Perinatal mortality</topic><topic>Prematurity</topic><topic>Psychomotor development</topic><topic>Psychomotor Disorders - epidemiology</topic><topic>Psychomotor Disorders - mortality</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ayoubi, J.M</creatorcontrib><creatorcontrib>Audibert, F</creatorcontrib><creatorcontrib>Boithias, C</creatorcontrib><creatorcontrib>Zupan, V</creatorcontrib><creatorcontrib>Taylor, S</creatorcontrib><creatorcontrib>Bosson, J.L</creatorcontrib><creatorcontrib>Frydman, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ayoubi, J.M</au><au>Audibert, F</au><au>Boithias, C</au><au>Zupan, V</au><au>Taylor, S</au><au>Bosson, J.L</au><au>Frydman, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perinatal factors affecting survival and survival without disability of extreme premature infants at two years of age</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2002-11-15</date><risdate>2002</risdate><volume>105</volume><issue>2</issue><spage>124</spage><epage>131</epage><pages>124-131</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><coden>EOGRAL</coden><abstract>Objective: To study obstetrical factors leading to very preterm delivery (between 24 and 28 weeks) and to relate these factors to neonatal outcome and psychomotor development at two years.
Study design: Among 144 infants born alive before 28 weeks of gestation at a single perinatal center between January 1993 and December 1996, we analyzed the influence on neonatal outcome and on psychomotor development at 24 months of a variety of perinatal and neonatal factors. Psychomotor development at two years was classified as: normal, borderline, or moderately or severely handicapped.
Results: During the study period, 114 women delivered live infants before 28 weeks’ gestation: 87 singletons, 25 sets of twins, 1 set of triplets and 1 set of quadruplets. All 144 live-born infants received neonatal resuscitation: 50 died before discharge. At two years of age, 6 of the 94 survivors were lost to follow-up. Assessments of the psychomotor development of the other 88 was normal for 52%; borderline for 20%, moderately handicapped for 20%, and severely handicapped for 8%. Multivariate analysis found that two factors affected survival: birthweight and fetal heart rate. (The 42% of infants with a birthweight below 700
g survived versus 83% above 900
g,
P<0.001, OR=5.2, 95% CI (confidence interval) [2.4–11.2].)
Conclusion: These data show the influence of perinatal factors on the outcome of very preterm infants; birthweight and fetal heart rate are strongly correlated with survival. Gestational age is a good predictor of psychomotor development at two years.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>12381473</pmid><doi>10.1016/S0301-2115(02)00158-6</doi><tpages>8</tpages></addata></record> |
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| ispartof | European journal of obstetrics & gynecology and reproductive biology, 2002-11, Vol.105 (2), p.124-131 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences Birth Weight Delivery. Postpartum. Lactation Disabled Children - statistics & numerical data Disorders Gestational Age Gynecology. Andrology. Obstetrics Heart Rate, Fetal Humans Infant, Newborn Infant, Premature Medical sciences Perinatal mortality Prematurity Psychomotor development Psychomotor Disorders - epidemiology Psychomotor Disorders - mortality Survival Rate |
| title | Perinatal factors affecting survival and survival without disability of extreme premature infants at two years of age |
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