Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains

Fibroblast growth factor receptors (FGFR) 1 and 3 have distinct mitogenic activities in vitro. In several cultured cell lines, FGFR1 transmits a potent mitogenic signal, whereas FGFR3 has little or no mitogenic activity. However, in other in vitro assays the FGFR3 intracellular domain is comparable...

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Veröffentlicht in:	Development (Cambridge) 2001-10, Vol.128 (19), p.3867-3876
Hauptverfasser:	Wang, Q, Green, R P, Zhao, G, Ornitz, D M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Development - genetics Bone Morphogenetic Proteins Chondrocytes - physiology Collagen - genetics Collagen - metabolism Growth Differentiation Factor 5 Growth Plate - cytology Growth Substances - genetics Growth Substances - metabolism Joints - abnormalities Joints - metabolism Joints - pathology Mice Mice, Transgenic Protein Structure, Tertiary Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Receptor, Fibroblast Growth Factor, Type 1 Receptor, Fibroblast Growth Factor, Type 3 Receptors, Fibroblast Growth Factor - genetics Receptors, Fibroblast Growth Factor - metabolism Regulatory Sequences, Nucleic Acid Signal Transduction Sternum - pathology
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