Free radical-induced double lesions in DNA
This review surveys the work that has been done on free radical-induced DNA double lesions. Double lesions consist of two modifications of the DNA in close proximity. Double lesions can be generated by a single free radical-initiating event and the mechanism of formation often involves the participa...
Gespeichert in:
| Veröffentlicht in: | Free Radical Biology and Medicine 2001-10, Vol.31 (7), p.856-868 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 868 |
|---|---|
| container_issue | 7 |
| container_start_page | 856 |
| container_title | Free Radical Biology and Medicine |
| container_volume | 31 |
| creator | Box, Harold C Dawidzik, Jean B Budzinski, Edwin E |
| description | This review surveys the work that has been done on free radical-induced DNA double lesions. Double lesions consist of two modifications of the DNA in close proximity. Double lesions can be generated by a single free radical-initiating event and the mechanism of formation often involves the participation of guanine. The identification of double lesions in oligomer and polymer DNA is reviewed and possible mechanisms of formation are outlined. The potential biological significance of double lesions is discussed. Double lesions induced by UV light are outside the scope of this review. |
| doi_str_mv | 10.1016/S0891-5849(01)00653-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72173296</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0891584901006530</els_id><sourcerecordid>72173296</sourcerecordid><originalsourceid>FETCH-LOGICAL-c392t-8600f15ee765d18c366a0a2ead9fed98f1bd409032cba58eabbc95e8cc4615c83</originalsourceid><addsrcrecordid>eNqF0EtLxDAQwPEgiq6Pj6D0JCpUZ5omTU6y-AbRg3oOaTKFSLfVZCv47e0-0KOnufxnBn6MHSKcI6C8eAGlMReq1CeApwBS8Bw22ARVxfNSaLnJJr_JDttN6R0ASsHVNttBFEpUUE7Y2W0kyqL1wdk2D50fHPnM90PdUtZSCn2XstBl10_TfbbV2DbRwXrusbfbm9er-_zx-e7havqYO66Lea4kQIOCqJLCo3JcSgu2IOt1Q16rBmtfggZeuNoKRbaunRaknCslCqf4Hjte3f2I_edAaW5mITlqW9tRPyRTFVjxQst_Q1RYcF2WYyhWoYt9SpEa8xHDzMZvg2AWmmapaRZUBtAsNQ2Me0frB0M9I_-3teYbg8tVQKPHV6BokgvUjYQhkpsb34d_XvwAt6KCig</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18123944</pqid></control><display><type>article</type><title>Free radical-induced double lesions in DNA</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Box, Harold C ; Dawidzik, Jean B ; Budzinski, Edwin E</creator><creatorcontrib>Box, Harold C ; Dawidzik, Jean B ; Budzinski, Edwin E</creatorcontrib><description>This review surveys the work that has been done on free radical-induced DNA double lesions. Double lesions consist of two modifications of the DNA in close proximity. Double lesions can be generated by a single free radical-initiating event and the mechanism of formation often involves the participation of guanine. The identification of double lesions in oligomer and polymer DNA is reviewed and possible mechanisms of formation are outlined. The potential biological significance of double lesions is discussed. Double lesions induced by UV light are outside the scope of this review.</description><identifier>ISSN: 0891-5849</identifier><identifier>EISSN: 1873-4596</identifier><identifier>DOI: 10.1016/S0891-5849(01)00653-0</identifier><identifier>PMID: 11585704</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; DNA - drug effects ; DNA - metabolism ; DNA damage ; DNA Damage - drug effects ; DNA Damage - physiology ; DNA repair ; Double lesions ; Fenton chemistry ; Free radical-induced DNA damage ; Free radicals ; Free Radicals - metabolism ; Free Radicals - pharmacology ; guanine ; Guanine - metabolism ; Humans ; Oligodeoxyribonucleotides - metabolism ; Oxygen - metabolism ; Radiation-induced DNA damage ; Reactive oxygen species (ROS) ; Reactive Oxygen Species - metabolism ; Reactive Oxygen Species - pharmacology ; Tandem lesions ; Vicinal lesions</subject><ispartof>Free Radical Biology and Medicine, 2001-10, Vol.31 (7), p.856-868</ispartof><rights>2001 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-8600f15ee765d18c366a0a2ead9fed98f1bd409032cba58eabbc95e8cc4615c83</citedby><cites>FETCH-LOGICAL-c392t-8600f15ee765d18c366a0a2ead9fed98f1bd409032cba58eabbc95e8cc4615c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0891584901006530$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,776,780,788,3537,27899,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11585704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Box, Harold C</creatorcontrib><creatorcontrib>Dawidzik, Jean B</creatorcontrib><creatorcontrib>Budzinski, Edwin E</creatorcontrib><title>Free radical-induced double lesions in DNA</title><title>Free Radical Biology and Medicine</title><addtitle>Free Radic Biol Med</addtitle><description>This review surveys the work that has been done on free radical-induced DNA double lesions. Double lesions consist of two modifications of the DNA in close proximity. Double lesions can be generated by a single free radical-initiating event and the mechanism of formation often involves the participation of guanine. The identification of double lesions in oligomer and polymer DNA is reviewed and possible mechanisms of formation are outlined. The potential biological significance of double lesions is discussed. Double lesions induced by UV light are outside the scope of this review.</description><subject>Animals</subject><subject>DNA - drug effects</subject><subject>DNA - metabolism</subject><subject>DNA damage</subject><subject>DNA Damage - drug effects</subject><subject>DNA Damage - physiology</subject><subject>DNA repair</subject><subject>Double lesions</subject><subject>Fenton chemistry</subject><subject>Free radical-induced DNA damage</subject><subject>Free radicals</subject><subject>Free Radicals - metabolism</subject><subject>Free Radicals - pharmacology</subject><subject>guanine</subject><subject>Guanine - metabolism</subject><subject>Humans</subject><subject>Oligodeoxyribonucleotides - metabolism</subject><subject>Oxygen - metabolism</subject><subject>Radiation-induced DNA damage</subject><subject>Reactive oxygen species (ROS)</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Reactive Oxygen Species - pharmacology</subject><subject>Tandem lesions</subject><subject>Vicinal lesions</subject><issn>0891-5849</issn><issn>1873-4596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtLxDAQwPEgiq6Pj6D0JCpUZ5omTU6y-AbRg3oOaTKFSLfVZCv47e0-0KOnufxnBn6MHSKcI6C8eAGlMReq1CeApwBS8Bw22ARVxfNSaLnJJr_JDttN6R0ASsHVNttBFEpUUE7Y2W0kyqL1wdk2D50fHPnM90PdUtZSCn2XstBl10_TfbbV2DbRwXrusbfbm9er-_zx-e7havqYO66Lea4kQIOCqJLCo3JcSgu2IOt1Q16rBmtfggZeuNoKRbaunRaknCslCqf4Hjte3f2I_edAaW5mITlqW9tRPyRTFVjxQst_Q1RYcF2WYyhWoYt9SpEa8xHDzMZvg2AWmmapaRZUBtAsNQ2Me0frB0M9I_-3teYbg8tVQKPHV6BokgvUjYQhkpsb34d_XvwAt6KCig</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Box, Harold C</creator><creator>Dawidzik, Jean B</creator><creator>Budzinski, Edwin E</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20011001</creationdate><title>Free radical-induced double lesions in DNA</title><author>Box, Harold C ; Dawidzik, Jean B ; Budzinski, Edwin E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-8600f15ee765d18c366a0a2ead9fed98f1bd409032cba58eabbc95e8cc4615c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>DNA - drug effects</topic><topic>DNA - metabolism</topic><topic>DNA damage</topic><topic>DNA Damage - drug effects</topic><topic>DNA Damage - physiology</topic><topic>DNA repair</topic><topic>Double lesions</topic><topic>Fenton chemistry</topic><topic>Free radical-induced DNA damage</topic><topic>Free radicals</topic><topic>Free Radicals - metabolism</topic><topic>Free Radicals - pharmacology</topic><topic>guanine</topic><topic>Guanine - metabolism</topic><topic>Humans</topic><topic>Oligodeoxyribonucleotides - metabolism</topic><topic>Oxygen - metabolism</topic><topic>Radiation-induced DNA damage</topic><topic>Reactive oxygen species (ROS)</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Reactive Oxygen Species - pharmacology</topic><topic>Tandem lesions</topic><topic>Vicinal lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Box, Harold C</creatorcontrib><creatorcontrib>Dawidzik, Jean B</creatorcontrib><creatorcontrib>Budzinski, Edwin E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Free Radical Biology and Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Box, Harold C</au><au>Dawidzik, Jean B</au><au>Budzinski, Edwin E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Free radical-induced double lesions in DNA</atitle><jtitle>Free Radical Biology and Medicine</jtitle><addtitle>Free Radic Biol Med</addtitle><date>2001-10-01</date><risdate>2001</risdate><volume>31</volume><issue>7</issue><spage>856</spage><epage>868</epage><pages>856-868</pages><issn>0891-5849</issn><eissn>1873-4596</eissn><abstract>This review surveys the work that has been done on free radical-induced DNA double lesions. Double lesions consist of two modifications of the DNA in close proximity. Double lesions can be generated by a single free radical-initiating event and the mechanism of formation often involves the participation of guanine. The identification of double lesions in oligomer and polymer DNA is reviewed and possible mechanisms of formation are outlined. The potential biological significance of double lesions is discussed. Double lesions induced by UV light are outside the scope of this review.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11585704</pmid><doi>10.1016/S0891-5849(01)00653-0</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0891-5849 |
| ispartof | Free Radical Biology and Medicine, 2001-10, Vol.31 (7), p.856-868 |
| issn | 0891-5849 1873-4596 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72173296 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals DNA - drug effects DNA - metabolism DNA damage DNA Damage - drug effects DNA Damage - physiology DNA repair Double lesions Fenton chemistry Free radical-induced DNA damage Free radicals Free Radicals - metabolism Free Radicals - pharmacology guanine Guanine - metabolism Humans Oligodeoxyribonucleotides - metabolism Oxygen - metabolism Radiation-induced DNA damage Reactive oxygen species (ROS) Reactive Oxygen Species - metabolism Reactive Oxygen Species - pharmacology Tandem lesions Vicinal lesions |
| title | Free radical-induced double lesions in DNA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-16T01%3A37%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Free%20radical-induced%20double%20lesions%20in%20DNA&rft.jtitle=Free%20Radical%20Biology%20and%20Medicine&rft.au=Box,%20Harold%20C&rft.date=2001-10-01&rft.volume=31&rft.issue=7&rft.spage=856&rft.epage=868&rft.pages=856-868&rft.issn=0891-5849&rft.eissn=1873-4596&rft_id=info:doi/10.1016/S0891-5849(01)00653-0&rft_dat=%3Cproquest_cross%3E72173296%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18123944&rft_id=info:pmid/11585704&rft_els_id=S0891584901006530&rfr_iscdi=true |