The coagulation cascade: initiation, maintenance, and regulation

There are two principal mechanisms to stop the loss of blood in higher organisms following vascular injury. The reactions set the stage for the coagulation cascade and fibrin formation by making available negatively charged phospholipids such as phosphatidylserine on the surface of the activated pla...

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Veröffentlicht in:	Biochemistry (Easton) 1991-10, Vol.30 (43), p.10363-10370
Hauptverfasser:	Davie, Earl W, Fujikawa, Kazuo, Kisiel, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Coagulation - physiology Blood Coagulation Factors - physiology Blood coagulation. Blood cells Fundamental and applied biological sciences. Psychology General aspects, investigation methods, hemostasis, fibrinolysis Humans Molecular and cellular biology reviews
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	There are two principal mechanisms to stop the loss of blood in higher organisms following vascular injury. The reactions set the stage for the coagulation cascade and fibrin formation by making available negatively charged phospholipids such as phosphatidylserine on the surface of the activated platelets or damaged cell membranes.
ISSN:	0006-2960 1520-4995
DOI:	10.1021/bi00107a001