Effect of corticosteroids on human osteoclast formation and activity

Chronic corticosteroid treatment is known to induce bone loss and osteoporosis. Osteoclasts are specialised bone-resorbing cells that are formed from mononuclear phagocyte precursors that circulate in the monocyte fraction. In this study we have examined the effect of the synthetic glucocorticoid, d...

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Veröffentlicht in:	Journal of endocrinology 2002-10, Vol.175 (1), p.155-163
Hauptverfasser:	Hirayama, T, Sabokbar, A, Athanasou, NA
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - analysis Adult Biological and medical sciences Biomarkers - analysis Cell Differentiation - drug effects Cell Division - drug effects Cells, Cultured Dexamethasone - pharmacology Drug toxicity and drugs side effects treatment Female Glucocorticoids - pharmacology Humans Isoenzymes - analysis Male Medical sciences Middle Aged Monocytes - cytology Monocytes - drug effects Osteoclasts - cytology Osteogenesis - drug effects Pharmacology. Drug treatments Receptors, Vitronectin - analysis Stimulation, Chemical Tartrate-Resistant Acid Phosphatase Toxicity: osteoarticular system
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