Fibrinogen Kanazawa: a congenital dysfibrinogenaemia with delayed polymerization having a replacement of proline-18 by leucine in the Aα-chain

Congenital dysfibrinogenaemia was found in a 39-year-old female and her two children. The proposita, apparently heterozygous for this abnormality, had no episode of bleeding or thrombosis. The abnormal fibrinogen showed normal release of fibrinopeptides A and B but impaired polymerization of the fib...

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Veröffentlicht in:	Blood coagulation & fibrinolysis 1991-06, Vol.2 (3), p.413-418
Hauptverfasser:	Uotani, C, Miyata, T, Kumabashiri, I, Asakura, H, Saito, M, Matsuda, T, Kajiyama, S, Iwanaga, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Sequence Blood Coagulation Disorders - blood Blood Coagulation Disorders - congenital Blood Coagulation Tests Female Fibrinogens, Abnormal - chemistry Fibrinogens, Abnormal - metabolism Fibrinopeptide A - metabolism Fibrinopeptide B - metabolism Humans Leucine Molecular Sequence Data Polymers - metabolism Proline
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