Salt Sensitivity and Central Dopaminergic Activity in Patients With Essential Hypertension
The pathophysiological role of the central dopaminergic mechanism in human essential hypertension (EHT) is still unknown, so we investigated a possible relationship between the central dopaminergic activity and salt sensitivity to blood pressure in patients with EHT. We divided 22 inpatients with EH...
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| Veröffentlicht in: | American journal of hypertension 1991-09, Vol.4 (9), p.745-751 |
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| creator | Hamasaki, Shin-ichiro Umeda, Teruhisa Sato, Tatsuo |
| description | The pathophysiological role of the central dopaminergic mechanism in human essential hypertension (EHT) is still unknown, so we investigated a possible relationship between the central dopaminergic activity and salt sensitivity to blood pressure in patients with EHT. We divided 22 inpatients with EHT into salt-sensitive (SS, n = 11) and nonsalt-sensitive (NSS, n = 11) groups according to an 8% increase of mean blood pressure (MBP) when dietary salt intake was increased from 2 g/day to 20 g/day for two periods of 7 days each. The change of central dopaminergic activity by salt load was evaluated as the percentage change of plasma prolactin (PRL) response to a small dose (25 μg of thyrotropin-releasing hormone (TRH) administered intravenously. The mean percentage change of PRL response by salt load in the SS group was −9.4 ± 8.5% (mean ± SEM), which was remarkably lower than the 26.8 ± 5.5% in the NSS group (P |
| doi_str_mv | 10.1093/ajh/4.9.745 |
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We divided 22 inpatients with EHT into salt-sensitive (SS, n = 11) and nonsalt-sensitive (NSS, n = 11) groups according to an 8% increase of mean blood pressure (MBP) when dietary salt intake was increased from 2 g/day to 20 g/day for two periods of 7 days each. The change of central dopaminergic activity by salt load was evaluated as the percentage change of plasma prolactin (PRL) response to a small dose (25 μg of thyrotropin-releasing hormone (TRH) administered intravenously. The mean percentage change of PRL response by salt load in the SS group was −9.4 ± 8.5% (mean ± SEM), which was remarkably lower than the 26.8 ± 5.5% in the NSS group (P <.01). There was a significant negative correlation between the percentage change of PRL response and that of MBP by salt load (r = −0.456, P <.05). These results suggest that a lack of activation of the central dopaminergic system by salt load may contribute in part to a rise in blood pressure in SS patients with EHT. Am J Hypertens 1991;4:745–751</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>EISSN: 1879-1905</identifier><identifier>DOI: 10.1093/ajh/4.9.745</identifier><identifier>PMID: 1681822</identifier><language>eng</language><publisher>New York, NY: Oxford University Press</publisher><subject>Adult ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Cardiology. Vascular system ; central dopaminergic activity ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Dopamine Agents - pharmacology ; Dose-Response Relationship, Drug ; Essential hypertension ; Female ; Humans ; Hypertension - physiopathology ; Injections, Intravenous ; Male ; Medical sciences ; Middle Aged ; prolactin ; Prolactin - blood ; salt sensitivity ; Sodium - pharmacology ; Thyrotropin-Releasing Hormone - administration & dosage ; Thyrotropin-Releasing Hormone - pharmacology ; thyrotropin-releasing hormone test</subject><ispartof>American journal of hypertension, 1991-09, Vol.4 (9), p.745-751</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-941daa2c77572266df304b7f70b6c2ad4018df1ffda098f9038d3347ba0cb063</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5231952$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1681822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamasaki, Shin-ichiro</creatorcontrib><creatorcontrib>Umeda, Teruhisa</creatorcontrib><creatorcontrib>Sato, Tatsuo</creatorcontrib><title>Salt Sensitivity and Central Dopaminergic Activity in Patients With Essential Hypertension</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>The pathophysiological role of the central dopaminergic mechanism in human essential hypertension (EHT) is still unknown, so we investigated a possible relationship between the central dopaminergic activity and salt sensitivity to blood pressure in patients with EHT. We divided 22 inpatients with EHT into salt-sensitive (SS, n = 11) and nonsalt-sensitive (NSS, n = 11) groups according to an 8% increase of mean blood pressure (MBP) when dietary salt intake was increased from 2 g/day to 20 g/day for two periods of 7 days each. The change of central dopaminergic activity by salt load was evaluated as the percentage change of plasma prolactin (PRL) response to a small dose (25 μg of thyrotropin-releasing hormone (TRH) administered intravenously. The mean percentage change of PRL response by salt load in the SS group was −9.4 ± 8.5% (mean ± SEM), which was remarkably lower than the 26.8 ± 5.5% in the NSS group (P <.01). There was a significant negative correlation between the percentage change of PRL response and that of MBP by salt load (r = −0.456, P <.05). These results suggest that a lack of activation of the central dopaminergic system by salt load may contribute in part to a rise in blood pressure in SS patients with EHT. Am J Hypertens 1991;4:745–751</description><subject>Adult</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Cardiology. Vascular system</subject><subject>central dopaminergic activity</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Dopamine Agents - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Essential hypertension</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - physiopathology</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>prolactin</subject><subject>Prolactin - blood</subject><subject>salt sensitivity</subject><subject>Sodium - pharmacology</subject><subject>Thyrotropin-Releasing Hormone - administration & dosage</subject><subject>Thyrotropin-Releasing Hormone - pharmacology</subject><subject>thyrotropin-releasing hormone test</subject><issn>0895-7061</issn><issn>1941-7225</issn><issn>1879-1905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEQhoMotX6cPAt7EC-yNdlskt2j1GoFwWoLipcwm000ut2tSSr235vSoqdheJ95GR6ETggeEFzSS_h4v8wH5UDkbAf1SZmTVGQZ20V9XJQsFZiTfXTg_QfGOOec9FCP8IIUWdZHr1NoQjLVrbfBftuwSqCtk6Fug4Mmue4WMLetdm9WJVdqS9g2mUCwkfHJsw3vycj7uNh4MF4ttAvrtq49QnsGGq-Pt_MQzW5Gs-E4vX-4vRte3aeKMhLS-G4NkCkhWPya89pQnFfCCFxxlUGdY1LUhhhTAy4LU2Ja1JTmogKsKszpITrf1C5c97XUPsi59Uo3DbS6W3opMiIIZSyCFxtQuc57p41cODsHt5IEy7VIGUXKXJYyioz06bZ2Wc11_c9uzMX8bJuDV9AYB62y_g9jGSUlW2PpBrM-6J-_GNyn5IIKJscvr5I_zqZPE05lQX8BmUCLLg</recordid><startdate>19910901</startdate><enddate>19910901</enddate><creator>Hamasaki, Shin-ichiro</creator><creator>Umeda, Teruhisa</creator><creator>Sato, Tatsuo</creator><general>Oxford University Press</general><general>Elsevier Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910901</creationdate><title>Salt Sensitivity and Central Dopaminergic Activity in Patients With Essential Hypertension</title><author>Hamasaki, Shin-ichiro ; Umeda, Teruhisa ; Sato, Tatsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-941daa2c77572266df304b7f70b6c2ad4018df1ffda098f9038d3347ba0cb063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Cardiology. Vascular system</topic><topic>central dopaminergic activity</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Dopamine Agents - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Essential hypertension</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - physiopathology</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>prolactin</topic><topic>Prolactin - blood</topic><topic>salt sensitivity</topic><topic>Sodium - pharmacology</topic><topic>Thyrotropin-Releasing Hormone - administration & dosage</topic><topic>Thyrotropin-Releasing Hormone - pharmacology</topic><topic>thyrotropin-releasing hormone test</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamasaki, Shin-ichiro</creatorcontrib><creatorcontrib>Umeda, Teruhisa</creatorcontrib><creatorcontrib>Sato, Tatsuo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamasaki, Shin-ichiro</au><au>Umeda, Teruhisa</au><au>Sato, Tatsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salt Sensitivity and Central Dopaminergic Activity in Patients With Essential Hypertension</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>1991-09-01</date><risdate>1991</risdate><volume>4</volume><issue>9</issue><spage>745</spage><epage>751</epage><pages>745-751</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><eissn>1879-1905</eissn><abstract>The pathophysiological role of the central dopaminergic mechanism in human essential hypertension (EHT) is still unknown, so we investigated a possible relationship between the central dopaminergic activity and salt sensitivity to blood pressure in patients with EHT. We divided 22 inpatients with EHT into salt-sensitive (SS, n = 11) and nonsalt-sensitive (NSS, n = 11) groups according to an 8% increase of mean blood pressure (MBP) when dietary salt intake was increased from 2 g/day to 20 g/day for two periods of 7 days each. The change of central dopaminergic activity by salt load was evaluated as the percentage change of plasma prolactin (PRL) response to a small dose (25 μg of thyrotropin-releasing hormone (TRH) administered intravenously. The mean percentage change of PRL response by salt load in the SS group was −9.4 ± 8.5% (mean ± SEM), which was remarkably lower than the 26.8 ± 5.5% in the NSS group (P <.01). There was a significant negative correlation between the percentage change of PRL response and that of MBP by salt load (r = −0.456, P <.05). These results suggest that a lack of activation of the central dopaminergic system by salt load may contribute in part to a rise in blood pressure in SS patients with EHT. Am J Hypertens 1991;4:745–751</abstract><cop>New York, NY</cop><pub>Oxford University Press</pub><pmid>1681822</pmid><doi>10.1093/ajh/4.9.745</doi><tpages>7</tpages></addata></record> |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Adult Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood Pressure - physiology Cardiology. Vascular system central dopaminergic activity Clinical manifestations. Epidemiology. Investigative techniques. Etiology Dopamine Agents - pharmacology Dose-Response Relationship, Drug Essential hypertension Female Humans Hypertension - physiopathology Injections, Intravenous Male Medical sciences Middle Aged prolactin Prolactin - blood salt sensitivity Sodium - pharmacology Thyrotropin-Releasing Hormone - administration & dosage Thyrotropin-Releasing Hormone - pharmacology thyrotropin-releasing hormone test |
| title | Salt Sensitivity and Central Dopaminergic Activity in Patients With Essential Hypertension |
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