Effects of hippocampal lesions on patterned motor learning in the rat
Motor skill learning in rats has been linked to cerebellar function as well as to cortical and striatal influences. The present study evaluated the contribution of the hippocampus to motor learning. Adult male rats received electrolytic lesions designed to selectively destroy the hippocampus; a sham...
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| Veröffentlicht in: | Brain research bulletin 2002-09, Vol.58 (6), p.581-586 |
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| container_title | Brain research bulletin |
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| creator | Gould, T.J Rowe, W.B Heman, K.L Mesches, M.H Young, D.A Rose, G.M Bickford, P.C |
| description | Motor skill learning in rats has been linked to cerebellar function as well as to cortical and striatal influences. The present study evaluated the contribution of the hippocampus to motor learning. Adult male rats received electrolytic lesions designed to selectively destroy the hippocampus; a sham-lesioned group of animals served as a control. The animals with hippocampal lesions acquired a patterned motor learning task as well as sham controls. In contrast, rats with hippocampal lesions were impaired in spatial, but not cued, learning in the Morris water maze. In addition, lesioned rats showed profound impairment in the novel object recognition memory task, when a 1-h delay was used between training and testing. Taken together, these results suggest that the hippocampus is not necessary during acquisition of the motor learning task. |
| doi_str_mv | 10.1016/S0361-9230(02)00832-8 |
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The present study evaluated the contribution of the hippocampus to motor learning. Adult male rats received electrolytic lesions designed to selectively destroy the hippocampus; a sham-lesioned group of animals served as a control. The animals with hippocampal lesions acquired a patterned motor learning task as well as sham controls. In contrast, rats with hippocampal lesions were impaired in spatial, but not cued, learning in the Morris water maze. In addition, lesioned rats showed profound impairment in the novel object recognition memory task, when a 1-h delay was used between training and testing. 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| ispartof | Brain research bulletin, 2002-09, Vol.58 (6), p.581-586 |
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| subjects | Anatomical correlates of behavior Animals Behavioral psychophysiology Biological and medical sciences Cerebellum Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - physiology Learning Learning - physiology Male Memory Morris water maze Motor learning Motor Skills - physiology Novel object recognition Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Inbred F344 Spatial Behavior - physiology |
| title | Effects of hippocampal lesions on patterned motor learning in the rat |
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