Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins

Background: Postmortem studies have provided evidence for abnormalities of the γ-aminobutyric acid (GABA)-ergic system in schizophrenia, including deficits of GABA-containing interneurons. The calcium-binding proteins parvalbumin, calbindin, and calretinin can be used as markers for specific subpopu...

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Veröffentlicht in:	Biological psychiatry (1969) 2002-10, Vol.52 (7), p.708-715
Hauptverfasser:	Beasley, Clare L, Zhang, Zhi J, Patten, Iain, Reynolds, Gavin P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Biological and medical sciences bipolar disorder calbindin Calbindin 2 Calbindins Calcium-Binding Proteins - metabolism calretinin Cell Count Female gamma-Aminobutyric Acid - metabolism Humans Immunohistochemistry interneuron Interneurons - metabolism Interneurons - pathology Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Nervous system Parvalbumin Parvalbumins - metabolism Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prefrontal Cortex - metabolism Prefrontal Cortex - pathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses S100 Calcium Binding Protein G - metabolism Schizophrenia Schizophrenia - metabolism Schizophrenia - pathology
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