Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins
Background: Postmortem studies have provided evidence for abnormalities of the γ-aminobutyric acid (GABA)-ergic system in schizophrenia, including deficits of GABA-containing interneurons. The calcium-binding proteins parvalbumin, calbindin, and calretinin can be used as markers for specific subpopu...
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| Veröffentlicht in: | Biological psychiatry (1969) 2002-10, Vol.52 (7), p.708-715 |
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| creator | Beasley, Clare L Zhang, Zhi J Patten, Iain Reynolds, Gavin P |
| description | Background: Postmortem studies have provided evidence for abnormalities of the γ-aminobutyric acid (GABA)-ergic system in schizophrenia, including deficits of GABA-containing interneurons. The calcium-binding proteins parvalbumin, calbindin, and calretinin can be used as markers for specific subpopulations of cortical GABAergic interneurons.
Methods: Following our previous observation of a reduction in the density of parvalbumin- but not calretinin-immunoreactive cells in the prefrontal cortex (Brodmann area 10) in schizophrenia, we have quantified the laminar density of neurons immunoreactive for the calcium-binding proteins parvalbumin, calbindin, and calretinin in a further prefrontal cortical region (Brodmann area 9) in patients with schizophrenia, bipolar disorder, major depression, and in matched control subjects (each group
n = 15).
Results: Initial statistical analysis revealed reductions in the total cortical density of parvalbumin- and calbindin- but not calretinin-immunoreactive neurons in schizophrenia relative to control subjects. Further analysis comparing individual laminar densities between groups indicated that, following correction for multiple comparisons, only a reduction in calbindin-immunoreactive neurons in cortical layer II in the schizophrenic group attained statistical significance.
Conclusions: These findings suggest that deficits of specific GABAergic neurons, defined by the presence of calcium-binding proteins, are present in schizophrenia. Trends toward similar reductions are observed in bipolar disorder. |
| doi_str_mv | 10.1016/S0006-3223(02)01360-4 |
| format | Article |
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Methods: Following our previous observation of a reduction in the density of parvalbumin- but not calretinin-immunoreactive cells in the prefrontal cortex (Brodmann area 10) in schizophrenia, we have quantified the laminar density of neurons immunoreactive for the calcium-binding proteins parvalbumin, calbindin, and calretinin in a further prefrontal cortical region (Brodmann area 9) in patients with schizophrenia, bipolar disorder, major depression, and in matched control subjects (each group
n = 15).
Results: Initial statistical analysis revealed reductions in the total cortical density of parvalbumin- and calbindin- but not calretinin-immunoreactive neurons in schizophrenia relative to control subjects. Further analysis comparing individual laminar densities between groups indicated that, following correction for multiple comparisons, only a reduction in calbindin-immunoreactive neurons in cortical layer II in the schizophrenic group attained statistical significance.
Conclusions: These findings suggest that deficits of specific GABAergic neurons, defined by the presence of calcium-binding proteins, are present in schizophrenia. Trends toward similar reductions are observed in bipolar disorder.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/S0006-3223(02)01360-4</identifier><identifier>PMID: 12372661</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; bipolar disorder ; calbindin ; Calbindin 2 ; Calbindins ; Calcium-Binding Proteins - metabolism ; calretinin ; Cell Count ; Female ; gamma-Aminobutyric Acid - metabolism ; Humans ; Immunohistochemistry ; interneuron ; Interneurons - metabolism ; Interneurons - pathology ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Nervous system ; Parvalbumin ; Parvalbumins - metabolism ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Prefrontal Cortex - metabolism ; Prefrontal Cortex - pathology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; S100 Calcium Binding Protein G - metabolism ; Schizophrenia ; Schizophrenia - metabolism ; Schizophrenia - pathology</subject><ispartof>Biological psychiatry (1969), 2002-10, Vol.52 (7), p.708-715</ispartof><rights>2002 Society of Biological Psychiatry</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-25e1b90ea9a35e6bed9ae64c837e1bf00c63a258b5a4a8b0804e9174b2406e1f3</citedby><cites>FETCH-LOGICAL-c556t-25e1b90ea9a35e6bed9ae64c837e1bf00c63a258b5a4a8b0804e9174b2406e1f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322302013604$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13969090$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12372661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beasley, Clare L</creatorcontrib><creatorcontrib>Zhang, Zhi J</creatorcontrib><creatorcontrib>Patten, Iain</creatorcontrib><creatorcontrib>Reynolds, Gavin P</creatorcontrib><title>Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background: Postmortem studies have provided evidence for abnormalities of the γ-aminobutyric acid (GABA)-ergic system in schizophrenia, including deficits of GABA-containing interneurons. The calcium-binding proteins parvalbumin, calbindin, and calretinin can be used as markers for specific subpopulations of cortical GABAergic interneurons.
Methods: Following our previous observation of a reduction in the density of parvalbumin- but not calretinin-immunoreactive cells in the prefrontal cortex (Brodmann area 10) in schizophrenia, we have quantified the laminar density of neurons immunoreactive for the calcium-binding proteins parvalbumin, calbindin, and calretinin in a further prefrontal cortical region (Brodmann area 9) in patients with schizophrenia, bipolar disorder, major depression, and in matched control subjects (each group
n = 15).
Results: Initial statistical analysis revealed reductions in the total cortical density of parvalbumin- and calbindin- but not calretinin-immunoreactive neurons in schizophrenia relative to control subjects. Further analysis comparing individual laminar densities between groups indicated that, following correction for multiple comparisons, only a reduction in calbindin-immunoreactive neurons in cortical layer II in the schizophrenic group attained statistical significance.
Conclusions: These findings suggest that deficits of specific GABAergic neurons, defined by the presence of calcium-binding proteins, are present in schizophrenia. Trends toward similar reductions are observed in bipolar disorder.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>bipolar disorder</subject><subject>calbindin</subject><subject>Calbindin 2</subject><subject>Calbindins</subject><subject>Calcium-Binding Proteins - metabolism</subject><subject>calretinin</subject><subject>Cell Count</subject><subject>Female</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>interneuron</subject><subject>Interneurons - metabolism</subject><subject>Interneurons - pathology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Parvalbumin</subject><subject>Parvalbumins - metabolism</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Prefrontal Cortex - pathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>S100 Calcium Binding Protein G - metabolism</subject><subject>Schizophrenia</subject><subject>Schizophrenia - metabolism</subject><subject>Schizophrenia - pathology</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhq0KVBban9DKFyo4hI7txElOaIv4kpB6oD1bjjNhp8o6WztZiZ746Xg_VI6cbGueeWf0mLEvAi4ECP39EQB0pqRUZyDPQSgNWf6BzURVqkzmIA_Y7D9yxI5j_JOepZTiIzsSUpVSazFjL4_YoxtpjbzFjhyNkZPnq4BdGPxoe-6GMJJLl9v5jzmGJ3Lc45SKWzC6Bf0bVouAnuw2wmPLm2c-LnCTEtE75EPHU4KjaZk15FvyT6k2jEg-fmKHne0jft6fJ-z3zfWvq7vs4eft_dX8IXNFocdMFiiaGtDWVhWoG2xrizp3lSpToQNwWllZVE1hc1s1UEGOtSjzJqnQKDp1wr7tctPgvxPG0SwpOux763GYoiml0GUhqgQWO9CFIcbkwawCLW14NgLMRr3Zqjcbrwak2ao3eer7uh8wNUts37r2rhNwugdsTDa6YL2j-MapWtdQQ-IudxwmHWvCYKKjjcaWQvoq0w70ziqvWBuiEw</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Beasley, Clare L</creator><creator>Zhang, Zhi J</creator><creator>Patten, Iain</creator><creator>Reynolds, Gavin P</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins</title><author>Beasley, Clare L ; Zhang, Zhi J ; Patten, Iain ; Reynolds, Gavin P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-25e1b90ea9a35e6bed9ae64c837e1bf00c63a258b5a4a8b0804e9174b2406e1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>bipolar disorder</topic><topic>calbindin</topic><topic>Calbindin 2</topic><topic>Calbindins</topic><topic>Calcium-Binding Proteins - metabolism</topic><topic>calretinin</topic><topic>Cell Count</topic><topic>Female</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>interneuron</topic><topic>Interneurons - metabolism</topic><topic>Interneurons - pathology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Parvalbumin</topic><topic>Parvalbumins - metabolism</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Prefrontal Cortex - pathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>S100 Calcium Binding Protein G - metabolism</topic><topic>Schizophrenia</topic><topic>Schizophrenia - metabolism</topic><topic>Schizophrenia - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beasley, Clare L</creatorcontrib><creatorcontrib>Zhang, Zhi J</creatorcontrib><creatorcontrib>Patten, Iain</creatorcontrib><creatorcontrib>Reynolds, Gavin P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beasley, Clare L</au><au>Zhang, Zhi J</au><au>Patten, Iain</au><au>Reynolds, Gavin P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>52</volume><issue>7</issue><spage>708</spage><epage>715</epage><pages>708-715</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background: Postmortem studies have provided evidence for abnormalities of the γ-aminobutyric acid (GABA)-ergic system in schizophrenia, including deficits of GABA-containing interneurons. The calcium-binding proteins parvalbumin, calbindin, and calretinin can be used as markers for specific subpopulations of cortical GABAergic interneurons.
Methods: Following our previous observation of a reduction in the density of parvalbumin- but not calretinin-immunoreactive cells in the prefrontal cortex (Brodmann area 10) in schizophrenia, we have quantified the laminar density of neurons immunoreactive for the calcium-binding proteins parvalbumin, calbindin, and calretinin in a further prefrontal cortical region (Brodmann area 9) in patients with schizophrenia, bipolar disorder, major depression, and in matched control subjects (each group
n = 15).
Results: Initial statistical analysis revealed reductions in the total cortical density of parvalbumin- and calbindin- but not calretinin-immunoreactive neurons in schizophrenia relative to control subjects. Further analysis comparing individual laminar densities between groups indicated that, following correction for multiple comparisons, only a reduction in calbindin-immunoreactive neurons in cortical layer II in the schizophrenic group attained statistical significance.
Conclusions: These findings suggest that deficits of specific GABAergic neurons, defined by the presence of calcium-binding proteins, are present in schizophrenia. Trends toward similar reductions are observed in bipolar disorder.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12372661</pmid><doi>10.1016/S0006-3223(02)01360-4</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Biological and medical sciences bipolar disorder calbindin Calbindin 2 Calbindins Calcium-Binding Proteins - metabolism calretinin Cell Count Female gamma-Aminobutyric Acid - metabolism Humans Immunohistochemistry interneuron Interneurons - metabolism Interneurons - pathology Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Nervous system Parvalbumin Parvalbumins - metabolism Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prefrontal Cortex - metabolism Prefrontal Cortex - pathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses S100 Calcium Binding Protein G - metabolism Schizophrenia Schizophrenia - metabolism Schizophrenia - pathology |
| title | Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins |
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