Unified Synthesis of Quinone Sesquiterpenes Based on a Radical Decarboxylation and Quinone Addition Reaction

A unified synthesis of several quinone sesquiterpenes is described herein. Essential to this strategy is a novel radical addition reaction that permits the attachment of a fully substituted bicyclic core 16 to a variably substituted quinone 10. The addition product 15 can be further functionalized,...

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Veröffentlicht in:	Journal of the American Chemical Society 2002-10, Vol.124 (41), p.12261-12267
Hauptverfasser:	Ling, Taotao, Poupon, Erwan, Rueden, Erik J, Kim, Sun H, Theodorakis, Emmanuel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds, terpenoids, prostaglandins, steroids Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Antineoplastic Agents - chemical synthesis Antiviral Agents - chemical synthesis Chemistry Cyclohexenes Exact sciences and technology Organic chemistry Preparations and properties Quinones - chemical synthesis Sesquiterpenes - chemical synthesis Substrate Specificity Terpenoids
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