Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands

Biaryl nitrile amines were prepared and found to have high affinity and selectivity for human and rat histamine H 3 receptors. Series of biaryl nitrile amines ligands of histamine H 3 is described.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2002-11, Vol.12 (21), p.3077-3079
Hauptverfasser:	Faghih, Ramin, Dwight, Wesley, Vasudevan, Anil, Dinges, Jurgen, Conner, Scott E., Esbenshade, Timothy A., Bennani, Youssef L., Hancock, Arthur A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biphenyl Compounds - chemical synthesis Biphenyl Compounds - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Guinea Pigs Humans In Vitro Techniques Ligands Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Nitriles - chemical synthesis Nitriles - pharmacology Pharmacology. Drug treatments Rats Receptors, Histamine H1 - drug effects Receptors, Histamine H1 - metabolism Receptors, Histamine H2 - drug effects Receptors, Histamine H2 - metabolism Receptors, Histamine H3 - drug effects Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	Biaryl nitrile amines were prepared and found to have high affinity and selectivity for human and rat histamine H 3 receptors. Series of biaryl nitrile amines ligands of histamine H 3 is described.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(02)00648-0