The role of enzyme and substrate concentration in the evaluation of serum angiotensin converting enzyme (ACE) inhibition by enalaprilat in vitro

The relationship between serum angiotensin converting enzyme (ACE) activity and concentration of the ACE inhibitor enalaprilat was determined in vitro in the presence of different concentrations ( S = 4–200 mM) of the substrate Hip-Gly-Gly. From Henderson plots, a competitive tight-binding relations...

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Veröffentlicht in:	Biochemical pharmacology 1991-10, Vol.42 (9), p.1729-1737
Hauptverfasser:	Weisser, Karin, Schloos, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Angiotensin-Converting Enzyme Inhibitors - pharmacology Antihypertensive agents Biological and medical sciences Cardiovascular system Dose-Response Relationship, Drug Enalaprilat - pharmacology Kinetics Mathematics Medical sciences Models, Theoretical Molecular Sequence Data Peptidyl-Dipeptidase A - blood Peptidyl-Dipeptidase A - metabolism Pharmacology. Drug treatments Protein Binding Spectrophotometry
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