Comparison of the measurement of serum cotinine levels by gas chromatography and radioimmunoassay
Standard cotinine solutions, controls and human serum samples containing cotinine have been measured by both radioimmunoassay (RIA) and gas chromatographic (GC) techniques. Cross-checks on standards and controls showed good agreement. However, for samples containing greater than 50 ng ml-1 of cotini...
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| Veröffentlicht in: | Analyst (London) 1991-07, Vol.116 (7), p.691-693 |
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| creator | ANDERSON, I. G. M PROCTOR, C. J HUSAGER, L |
| description | Standard cotinine solutions, controls and human serum samples containing cotinine have been measured by both radioimmunoassay (RIA) and gas chromatographic (GC) techniques. Cross-checks on standards and controls showed good agreement. However, for samples containing greater than 50 ng ml-1 of cotinine, RIA gave results on average 60% higher than GC. Determinations by using RIA and GC on samples containing less than 7 ng ml-1 of cotinine gave no significant correlation. The importance of the age of the serum sample has been investigated, and it is suggested that the age may affect the determination when dealing with low levels of cotinine. |
| doi_str_mv | 10.1039/AN9911600691 |
| format | Article |
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The importance of the age of the serum sample has been investigated, and it is suggested that the age may affect the determination when dealing with low levels of cotinine.</description><subject>Biological and medical sciences</subject><subject>Chromatography, Gas - methods</subject><subject>Cotinine - blood</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Radioimmunoassay - methods</subject><subject>Smoking - blood</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>0003-2654</issn><issn>1364-5528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtL7EAQRhu5ouNj5_ZCL8SV0X4nWcrgC0Q3ug7VnY6TS7p77EqE-fdGZtDlXRVV3-GDOoSccXbFmayvb57rmnPDmKn5HllwaVShtaj-kAVjTBbCaHVIjhD_zStnmh2QA16LqpRqQWCZwhpyjynS1NFx5WnwgFP2wcfx-4Q-T4G6NPaxj54O_tMPSO2GvgNSt8opwJjeM6xXGwqxpRnaPvUhTDEBImxOyH4HA_rT3Twmb3e3r8uH4unl_nF581Q4WbKxsLUEx1UFndOl7GRlWaukdrKulHCGO1GCcarzlnFhVNk6y1vrjFLgrDVMHpOLbe86p4_J49iEHp0fBog-TdiUghtZi_K_oNBcclbKGbzcgi4nxOy7Zp37AHnTcNZ8q28g_qqf8b-73skG3_7CW9dzfr7LAR0MXYboevzBNJuf0EJ-AQSXjIE</recordid><startdate>19910701</startdate><enddate>19910701</enddate><creator>ANDERSON, I. 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J ; HUSAGER, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-b93ac148afc573f38b0d435c39842c61c27a6c4feb012647dcb1dbc644acbb603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Biological and medical sciences</topic><topic>Chromatography, Gas - methods</topic><topic>Cotinine - blood</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Radioimmunoassay - methods</topic><topic>Smoking - blood</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ANDERSON, I. G. M</creatorcontrib><creatorcontrib>PROCTOR, C. 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The importance of the age of the serum sample has been investigated, and it is suggested that the age may affect the determination when dealing with low levels of cotinine.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><pmid>1928734</pmid><doi>10.1039/AN9911600691</doi><tpages>3</tpages></addata></record> |
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| ispartof | Analyst (London), 1991-07, Vol.116 (7), p.691-693 |
| issn | 0003-2654 1364-5528 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72163927 |
| source | MEDLINE; Royal Society of Chemistry Journals Archive; Alma/SFX Local Collection; Royal Society of Chemistry E-Journals |
| subjects | Biological and medical sciences Chromatography, Gas - methods Cotinine - blood Humans Medical sciences Radioimmunoassay - methods Smoking - blood Tobacco, tobacco smoking Toxicology |
| title | Comparison of the measurement of serum cotinine levels by gas chromatography and radioimmunoassay |
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