Changes of copper level and cytochrome c oxidase activity in the macular mouse with age

The macular mouse is an animal model of Menkes disease. The neurological degeneration is caused by decreased cuproenzymes activity, such as cytochrome c oxidase (CCO), associated with copper deficiency in the brain. We investigated the age-related changes in copper concentration and CCO activity in...

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Veröffentlicht in:	Brain & development (Tokyo. 1979) 1991-05, Vol.13 (3), p.184-186
Hauptverfasser:	Meguro, Yuko, Kodama, Hiroko, Abe, Toshiaki, Kobayashi, Shigeichi, Kodama, Yukio, Nishimura, Masahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Biological and medical sciences brain Brain - enzymology Copper - blood copper concentration cytochrome c oxidase Disease Models, Animal Electron Transport Complex IV - metabolism macular mice Male Medical sciences Menkes disease Menkes Kinky Hair Syndrome - enzymology Menkes Kinky Hair Syndrome - metabolism Metabolic diseases Mice Mice, Neurologic Mutants
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