Effects of amantadine and bromocriptine on startle and sensorimotor gating: parametric studies and cross-species comparisons
We recently reported that prepulse inhibition (PPI) in humans was increased by the dopamine (DA) agonist/ N-methyl- D-aspartate (NMDA) antagonist amantadine (200 mg), but was not significantly altered by the DA agonist bromocriptine (1.25-2.5 mg). PPI-enhancing effects of DA agonists occur in rats u...
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| Veröffentlicht in: | Psychopharmacologia 2002-10, Vol.164 (1), p.82-92 |
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| creator | SWERDLOW, Neal R STEPHANY, Nora SHOEMAKER, Jody M ROSS, Laura WASSERMAN, Lindsay C TALLEDO, Jo AUERBACH, Pamela P |
| description | We recently reported that prepulse inhibition (PPI) in humans was increased by the dopamine (DA) agonist/ N-methyl- D-aspartate (NMDA) antagonist amantadine (200 mg), but was not significantly altered by the DA agonist bromocriptine (1.25-2.5 mg). PPI-enhancing effects of DA agonists occur in rats under specific stimulus conditions, including short prepulse intervals ( |
| doi_str_mv | 10.1007/s00213-002-1172-5 |
| format | Article |
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Drug effects on PPI were assessed in male Sprague Dawley rats ( n=90) and humans ( n=49); startle habituation and PPIPSI were also studied in humans.
Amantadine and bromocriptine exhibited dose- and stimulus-dependent effects on PPI in rats, increasing PPI with short (10-20 ms) prepulse intervals, and decreasing PPI with long (60-120 ms) prepulse intervals. In humans, amantadine increased PPI with both short (20 ms) and long (120 ms) prepulse intervals. Bromocriptine had no significant effect on PPI in humans, but tended to increase PPI at short (20 ms) intervals. Amantadine eliminated PPIPSI.
Amantadine modifies prepulse effects on startle in rats and humans, and disrupts prepulse effects on perceived stimulus intensity in humans; bromocriptine has clear effects on PPI in rats, but not in humans. The divergent effects of amantadine on sensorimotor and sensory effects of prepulses may reflect a divergence of brain circuitry regulating these processes.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-002-1172-5</identifier><identifier>PMID: 12373422</identifier><identifier>CODEN: PSYPAG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Acoustic Stimulation - methods ; Adult ; Amantadine - pharmacology ; Analysis of Variance ; Animals ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Bromocriptine - pharmacology ; Dose-Response Relationship, Drug ; Humans ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychomotor Performance - drug effects ; Psychomotor Performance - physiology ; Rats ; Rats, Sprague-Dawley ; Reflex, Startle - drug effects ; Reflex, Startle - physiology ; Species Specificity</subject><ispartof>Psychopharmacologia, 2002-10, Vol.164 (1), p.82-92</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Springer-Verlag 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-1e006d29a78c76de2768ee66b5c89da5c166b0fefd6eb525b4de7083d76ed9e33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13974660$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12373422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SWERDLOW, Neal R</creatorcontrib><creatorcontrib>STEPHANY, Nora</creatorcontrib><creatorcontrib>SHOEMAKER, Jody M</creatorcontrib><creatorcontrib>ROSS, Laura</creatorcontrib><creatorcontrib>WASSERMAN, Lindsay C</creatorcontrib><creatorcontrib>TALLEDO, Jo</creatorcontrib><creatorcontrib>AUERBACH, Pamela P</creatorcontrib><title>Effects of amantadine and bromocriptine on startle and sensorimotor gating: parametric studies and cross-species comparisons</title><title>Psychopharmacologia</title><addtitle>Psychopharmacology (Berl)</addtitle><description>We recently reported that prepulse inhibition (PPI) in humans was increased by the dopamine (DA) agonist/ N-methyl- D-aspartate (NMDA) antagonist amantadine (200 mg), but was not significantly altered by the DA agonist bromocriptine (1.25-2.5 mg). PPI-enhancing effects of DA agonists occur in rats under specific stimulus conditions, including short prepulse intervals (<30 ms). We characterized the effects of amantadine and bromocriptine on PPI across species, assessing: (1) dose-response effects on PPI in rats over 10- to 120-ms prepulse intervals; (2) drug effects on PPI in humans, using this same range of prepulse intervals; and (3) drug effects on measures related to PPI, including PPI of perceived stimulus intensity (PPIPSI), and startle habituation.
Drug effects on PPI were assessed in male Sprague Dawley rats ( n=90) and humans ( n=49); startle habituation and PPIPSI were also studied in humans.
Amantadine and bromocriptine exhibited dose- and stimulus-dependent effects on PPI in rats, increasing PPI with short (10-20 ms) prepulse intervals, and decreasing PPI with long (60-120 ms) prepulse intervals. In humans, amantadine increased PPI with both short (20 ms) and long (120 ms) prepulse intervals. Bromocriptine had no significant effect on PPI in humans, but tended to increase PPI at short (20 ms) intervals. Amantadine eliminated PPIPSI.
Amantadine modifies prepulse effects on startle in rats and humans, and disrupts prepulse effects on perceived stimulus intensity in humans; bromocriptine has clear effects on PPI in rats, but not in humans. The divergent effects of amantadine on sensorimotor and sensory effects of prepulses may reflect a divergence of brain circuitry regulating these processes.</description><subject>Acoustic Stimulation - methods</subject><subject>Adult</subject><subject>Amantadine - pharmacology</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Bromocriptine - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychomotor Performance - drug effects</subject><subject>Psychomotor Performance - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reflex, Startle - drug effects</subject><subject>Reflex, Startle - physiology</subject><subject>Species Specificity</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1r3DAQhkVpSbbb_IBeiim0NzX6siT3FkKaFAK9pGchS-PgYFuuRj4U-uOrzS4EeqkOo2HmmYF5X0Lec_aFM2YukTHBJa2Rcm4EbV-RHVdSUMGMeE12jElJJW_tOXmL-MTqU1adkXMupJFKiB35czMMEAo2aWj87Jfi47hA45fY9DnNKeRxLYdKWhosPpfp2ERYMOVxTiXl5tFX5PFrs_rsZyh5DJXd4gj4zIacECmuEA6VkObKjZgWfEfeDH5CuDj9e_Lz283D9R29_3H7_frqngbV8kI5MKaj6LyxwegIwmgLoHXfBttF3wZeczbAEDX0rWh7FcEwK6PREDuQck8-H_euOf3aAIubRwwwTX6BtKEzompkDfsvyK3mTFXt9uTjP-BT2vJSj3CC204rLbsK8SP0LECGwa1VMZ9_O87cwUB3NNDV6A4GurbOfDgt3voZ4svEybEKfDoBHoOfhuyXMOILJzujtGbyL51dpUA</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>SWERDLOW, Neal R</creator><creator>STEPHANY, Nora</creator><creator>SHOEMAKER, Jody M</creator><creator>ROSS, Laura</creator><creator>WASSERMAN, Lindsay C</creator><creator>TALLEDO, Jo</creator><creator>AUERBACH, Pamela P</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Effects of amantadine and bromocriptine on startle and sensorimotor gating: parametric studies and cross-species comparisons</title><author>SWERDLOW, Neal R ; STEPHANY, Nora ; SHOEMAKER, Jody M ; ROSS, Laura ; WASSERMAN, Lindsay C ; TALLEDO, Jo ; AUERBACH, Pamela P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-1e006d29a78c76de2768ee66b5c89da5c166b0fefd6eb525b4de7083d76ed9e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acoustic Stimulation - methods</topic><topic>Adult</topic><topic>Amantadine - pharmacology</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Bromocriptine - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychomotor Performance - drug effects</topic><topic>Psychomotor Performance - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reflex, Startle - drug effects</topic><topic>Reflex, Startle - physiology</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SWERDLOW, Neal R</creatorcontrib><creatorcontrib>STEPHANY, Nora</creatorcontrib><creatorcontrib>SHOEMAKER, Jody M</creatorcontrib><creatorcontrib>ROSS, Laura</creatorcontrib><creatorcontrib>WASSERMAN, Lindsay C</creatorcontrib><creatorcontrib>TALLEDO, Jo</creatorcontrib><creatorcontrib>AUERBACH, Pamela P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SWERDLOW, Neal R</au><au>STEPHANY, Nora</au><au>SHOEMAKER, Jody M</au><au>ROSS, Laura</au><au>WASSERMAN, Lindsay C</au><au>TALLEDO, Jo</au><au>AUERBACH, Pamela P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of amantadine and bromocriptine on startle and sensorimotor gating: parametric studies and cross-species comparisons</atitle><jtitle>Psychopharmacologia</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>164</volume><issue>1</issue><spage>82</spage><epage>92</epage><pages>82-92</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><coden>PSYPAG</coden><abstract>We recently reported that prepulse inhibition (PPI) in humans was increased by the dopamine (DA) agonist/ N-methyl- D-aspartate (NMDA) antagonist amantadine (200 mg), but was not significantly altered by the DA agonist bromocriptine (1.25-2.5 mg). PPI-enhancing effects of DA agonists occur in rats under specific stimulus conditions, including short prepulse intervals (<30 ms). We characterized the effects of amantadine and bromocriptine on PPI across species, assessing: (1) dose-response effects on PPI in rats over 10- to 120-ms prepulse intervals; (2) drug effects on PPI in humans, using this same range of prepulse intervals; and (3) drug effects on measures related to PPI, including PPI of perceived stimulus intensity (PPIPSI), and startle habituation.
Drug effects on PPI were assessed in male Sprague Dawley rats ( n=90) and humans ( n=49); startle habituation and PPIPSI were also studied in humans.
Amantadine and bromocriptine exhibited dose- and stimulus-dependent effects on PPI in rats, increasing PPI with short (10-20 ms) prepulse intervals, and decreasing PPI with long (60-120 ms) prepulse intervals. In humans, amantadine increased PPI with both short (20 ms) and long (120 ms) prepulse intervals. Bromocriptine had no significant effect on PPI in humans, but tended to increase PPI at short (20 ms) intervals. Amantadine eliminated PPIPSI.
Amantadine modifies prepulse effects on startle in rats and humans, and disrupts prepulse effects on perceived stimulus intensity in humans; bromocriptine has clear effects on PPI in rats, but not in humans. The divergent effects of amantadine on sensorimotor and sensory effects of prepulses may reflect a divergence of brain circuitry regulating these processes.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12373422</pmid><doi>10.1007/s00213-002-1172-5</doi><tpages>11</tpages></addata></record> |
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| ispartof | Psychopharmacologia, 2002-10, Vol.164 (1), p.82-92 |
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| subjects | Acoustic Stimulation - methods Adult Amantadine - pharmacology Analysis of Variance Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Bromocriptine - pharmacology Dose-Response Relationship, Drug Humans Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychomotor Performance - drug effects Psychomotor Performance - physiology Rats Rats, Sprague-Dawley Reflex, Startle - drug effects Reflex, Startle - physiology Species Specificity |
| title | Effects of amantadine and bromocriptine on startle and sensorimotor gating: parametric studies and cross-species comparisons |
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