Argyrophilic carcinoma of the male breast. A neuroendocrine tumor containing predominantly chromogranin B (secretogranin I)
Argyrophilic tumors were diagnosed in 28 of 134 (20.8%) consecutive male patients who had a carcinoma of the breast removed between 1961 and 1990. Histologically, most argyrophilic tumors showed uniform cellularity and prevalent expansive growth. Ultrastructural observation disclosed the presence of...
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| Veröffentlicht in: | The American journal of surgical pathology 1991-11, Vol.15 (11), p.1063-1071 |
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| container_title | The American journal of surgical pathology |
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| creator | Scopsi, L Andreola, S Saccozzi, R Pilotti, S Boracchi, P Rosa, P Conti, A R Manzari, A Huttner, W B Rilke, F |
| description | Argyrophilic tumors were diagnosed in 28 of 134 (20.8%) consecutive male patients who had a carcinoma of the breast removed between 1961 and 1990. Histologically, most argyrophilic tumors showed uniform cellularity and prevalent expansive growth. Ultrastructural observation disclosed the presence of electron-dense cored granules in the cytoplasm of the tumor cells. By immunocytochemistry, 17 of 28 argyrophilic tumors (60.7%) contained chromogranin B (secretogranin I)-immunoreactive cells, whereas chromogranin A was present in four of these 17 tumors only (14.2%). Immunoblotting studies showed chromogranin B immunoreactivity similar to that found in normal neuroendocrine cells. Despite these findings, which would argue for a distinct morphologic and immunochemical entity, no statistically significant differences between argyrophilic and common male breast carcinomas were found when a number of clinicopathologic features and relapse-free survival were considered. |
| doi_str_mv | 10.1097/00000478-199111000-00005 |
| format | Article |
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A neuroendocrine tumor containing predominantly chromogranin B (secretogranin I)</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Scopsi, L ; Andreola, S ; Saccozzi, R ; Pilotti, S ; Boracchi, P ; Rosa, P ; Conti, A R ; Manzari, A ; Huttner, W B ; Rilke, F</creator><creatorcontrib>Scopsi, L ; Andreola, S ; Saccozzi, R ; Pilotti, S ; Boracchi, P ; Rosa, P ; Conti, A R ; Manzari, A ; Huttner, W B ; Rilke, F</creatorcontrib><description>Argyrophilic tumors were diagnosed in 28 of 134 (20.8%) consecutive male patients who had a carcinoma of the breast removed between 1961 and 1990. Histologically, most argyrophilic tumors showed uniform cellularity and prevalent expansive growth. Ultrastructural observation disclosed the presence of electron-dense cored granules in the cytoplasm of the tumor cells. By immunocytochemistry, 17 of 28 argyrophilic tumors (60.7%) contained chromogranin B (secretogranin I)-immunoreactive cells, whereas chromogranin A was present in four of these 17 tumors only (14.2%). Immunoblotting studies showed chromogranin B immunoreactivity similar to that found in normal neuroendocrine cells. 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A neuroendocrine tumor containing predominantly chromogranin B (secretogranin I)</title><title>The American journal of surgical pathology</title><addtitle>Am J Surg Pathol</addtitle><description>Argyrophilic tumors were diagnosed in 28 of 134 (20.8%) consecutive male patients who had a carcinoma of the breast removed between 1961 and 1990. Histologically, most argyrophilic tumors showed uniform cellularity and prevalent expansive growth. Ultrastructural observation disclosed the presence of electron-dense cored granules in the cytoplasm of the tumor cells. By immunocytochemistry, 17 of 28 argyrophilic tumors (60.7%) contained chromogranin B (secretogranin I)-immunoreactive cells, whereas chromogranin A was present in four of these 17 tumors only (14.2%). Immunoblotting studies showed chromogranin B immunoreactivity similar to that found in normal neuroendocrine cells. Despite these findings, which would argue for a distinct morphologic and immunochemical entity, no statistically significant differences between argyrophilic and common male breast carcinomas were found when a number of clinicopathologic features and relapse-free survival were considered.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Chromogranin A</subject><subject>Chromogranin B</subject><subject>Chromogranins - analysis</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurosecretory Systems - metabolism</subject><subject>Sex Factors</subject><subject>Survival Analysis</subject><issn>0147-5185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1PwzAMhnMAjTH4CUg5ITh0JOnSJscx8TFpEhc4V2nqbkFNMpL0MPHn6dgGvlh-_dqWH4QwJVNKZPlA9jErRUalpJQORbZX-BkaEzorM04Fv0CXMX4SQpmgbIRGVDLBeTFG3_Ow3gW_3ZjOaKxV0MZ5q7BvcdoAtqoDXAdQMU3xHDvogwfXeB2MA5x66wPW3iVlnHFrvA3QeGuccqnbYb0J3vp1UEMPP-K7CDpAOgnL-yt03qouwvUxT9DH89P74jVbvb0sF_NVphnnKZPDW7qoSVnPCqZkLspGyJaytihYXue6obJgkmgCgkBNdM1AEcE1JQqkLpp8gm4Pe7fBf_UQU2VN1NB1yoHvY1Uyyksp2WAUB6MOPsYAbbUNxqqwqyip9qyrE-vqj_WvxIfRm-ONvrbQ_A8eQOc_8EV9xQ</recordid><startdate>19911101</startdate><enddate>19911101</enddate><creator>Scopsi, L</creator><creator>Andreola, S</creator><creator>Saccozzi, R</creator><creator>Pilotti, S</creator><creator>Boracchi, P</creator><creator>Rosa, P</creator><creator>Conti, A R</creator><creator>Manzari, A</creator><creator>Huttner, W B</creator><creator>Rilke, F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19911101</creationdate><title>Argyrophilic carcinoma of the male breast. A neuroendocrine tumor containing predominantly chromogranin B (secretogranin I)</title><author>Scopsi, L ; Andreola, S ; Saccozzi, R ; Pilotti, S ; Boracchi, P ; Rosa, P ; Conti, A R ; Manzari, A ; Huttner, W B ; Rilke, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c255t-9991c6b07b462a9387d89f12f6623b3cd196290c0e80eb0cb2ea085c10ae9c6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - pathology</topic><topic>Chromogranin A</topic><topic>Chromogranin B</topic><topic>Chromogranins - analysis</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurosecretory Systems - metabolism</topic><topic>Sex Factors</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scopsi, L</creatorcontrib><creatorcontrib>Andreola, S</creatorcontrib><creatorcontrib>Saccozzi, R</creatorcontrib><creatorcontrib>Pilotti, S</creatorcontrib><creatorcontrib>Boracchi, P</creatorcontrib><creatorcontrib>Rosa, P</creatorcontrib><creatorcontrib>Conti, A R</creatorcontrib><creatorcontrib>Manzari, A</creatorcontrib><creatorcontrib>Huttner, W B</creatorcontrib><creatorcontrib>Rilke, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scopsi, L</au><au>Andreola, S</au><au>Saccozzi, R</au><au>Pilotti, S</au><au>Boracchi, P</au><au>Rosa, P</au><au>Conti, A R</au><au>Manzari, A</au><au>Huttner, W B</au><au>Rilke, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Argyrophilic carcinoma of the male breast. A neuroendocrine tumor containing predominantly chromogranin B (secretogranin I)</atitle><jtitle>The American journal of surgical pathology</jtitle><addtitle>Am J Surg Pathol</addtitle><date>1991-11-01</date><risdate>1991</risdate><volume>15</volume><issue>11</issue><spage>1063</spage><epage>1071</epage><pages>1063-1071</pages><issn>0147-5185</issn><abstract>Argyrophilic tumors were diagnosed in 28 of 134 (20.8%) consecutive male patients who had a carcinoma of the breast removed between 1961 and 1990. Histologically, most argyrophilic tumors showed uniform cellularity and prevalent expansive growth. Ultrastructural observation disclosed the presence of electron-dense cored granules in the cytoplasm of the tumor cells. By immunocytochemistry, 17 of 28 argyrophilic tumors (60.7%) contained chromogranin B (secretogranin I)-immunoreactive cells, whereas chromogranin A was present in four of these 17 tumors only (14.2%). Immunoblotting studies showed chromogranin B immunoreactivity similar to that found in normal neuroendocrine cells. Despite these findings, which would argue for a distinct morphologic and immunochemical entity, no statistically significant differences between argyrophilic and common male breast carcinomas were found when a number of clinicopathologic features and relapse-free survival were considered.</abstract><cop>United States</cop><pmid>1928556</pmid><doi>10.1097/00000478-199111000-00005</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0147-5185 |
| ispartof | The American journal of surgical pathology, 1991-11, Vol.15 (11), p.1063-1071 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Aged, 80 and over Breast Neoplasms - mortality Breast Neoplasms - pathology Chromogranin A Chromogranin B Chromogranins - analysis Humans Immunoblotting Immunohistochemistry Male Middle Aged Neurosecretory Systems - metabolism Sex Factors Survival Analysis |
| title | Argyrophilic carcinoma of the male breast. A neuroendocrine tumor containing predominantly chromogranin B (secretogranin I) |
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