Acidic phospholipids inhibit the DNA‐binding activity of DnaA protein, the initiator of chromosomal DNA replication in Escherichia coli

Summary In order to initiate chromosomal DNA replication in Escherichia coli, the DnaA protein must bind to both ATP and the origin of replication (oriC). Acidic phospholipids are known to inhibit DnaA binding to ATP, and here we examine the effects of various phospholipids on DnaA binding to oriC....

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Veröffentlicht in:	Molecular microbiology 2002-10, Vol.46 (1), p.245-256
Hauptverfasser:	Makise, Masaki, Mima, Shinji, Katsu, Takashi, Tsuchiya, Tomofusa, Mizushima, Tohru
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - metabolism Binding Sites - drug effects Cell Membrane - chemistry DNA Footprinting DNA Replication DNA, Bacterial - metabolism DNA-Binding Proteins - metabolism Escherichia coli - genetics Escherichia coli - metabolism Origin Recognition Complex Phospholipids - chemistry Phospholipids - pharmacology Viral Proteins - metabolism
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